Sentences with phrase «mimic human diseases»

Lai and 28 colleagues reported their results last week in the Journal of Molecular Cell Biology, saying they intend to create dogs with other DNA mutations, including ones that mimic human diseases such as Parkinson's and muscular dystrophy.

Before that happens, he says, researchers must show it works in animal models that more closely mimic human diseases.

Using a recently developed genome - editing technique called CRISPR, a Chinese team has successfully altered two target genes in cynomolgus monkeys, paving the way for the development of monkey models that mimic human diseases.

It might, for example, be used to mass - produce animals that mimic human diseases for research purposes.

In order to test their hypothesis in a model that more closely mimicked human disease, the researchers also tested the two drugs side - by - side on slices of tumors removed from patients during radical prostatectomy.

The investigators used the nanoparticle plus the iRGD to deliver irinotecan in a robust animal model for pancreatic cancer that closely mimics human disease.

His symptoms may come closer to mimicking the human disease than most mouse models of mental illness, because the gene involved has such a powerful effect.

In humans, α - synuclein would not necessarily turn out to be equally aggressive — mouse models of neurodegenerative diseases do not mimic human disease very closely — but scientists are taking the possibility seriously.

PD - L1 checkpoint inhibition and anti-CTLA-4 whole tumor cell vaccination counter adaptive immune resistance: A mouse neuroblastoma model that mimics human disease.

One concern within the field has been how poorly these mouse models really mimic human disease.»

Umrao Monani, Ph.D., assistant professor of neurology, searches for potential treatment strategies using genetically modified mice that mimic the human disease.

Not exact matches

The study of these highly unusual but devastating prion diseases has to date been thwarted by a lack of animal models that faithfully mimic the disease processes in humans.

Even the new studies clashed somewhat: Unlike the UCSF study, the German research found no major differences between the overall microbiomes of twins with and without MS. Finally, mouse models of MS are not perfect mimics of the human disease, and mouse immune systems aren't identical to people's.

The researchers caution, however, that it's not yet clear how closely the toxin - induced neural damage in rats mimics the state of diseased neurons in Parkinson's, especially because the mechanism that leads to such damage in humans remains unknown.

Their study published last week in Science Translational Medicine demonstrated that the fasting - mimicking diet reduced risks for cancer, diabetes, heart disease and other age - related diseases in human study participants who followed the special diet for five days each month in a three - month span.

Researchers then induced a disease in these mice that mimics human MS.. In one genetic group, both males and females fed a high salt diet showed worse clinical signs of the disease.

Researchers developed a new type of cell transplantation to treat mice mimicking a rare lung disease that one day could be used to treat this and other human lung diseases caused by dysfunctional immune cells.

They transplanted either normal or gene - corrected macrophages into the respiratory tracts of mice, which were bred to mimic the hereditary form of a human disease called hereditary pulmonary alveolar proteinosis (hPAP).

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

The researchers used mouse models that mimic the disease characteristics of pulmonary hypertension and pulmonary fibrosis in humans to study the effect of triciribine, which inhibits production of a protein called Akt1.

In research published in Molecular Cell, Rutgers scientists discovered that a protein (p62), which is supposed to act as an antioxidant to prevent cell damage, was not working efficiently in laboratory mice with liver and heart disease that mimicked these conditions in humans.

Experiments on mice and on heart cells obtained from infants born with congenital heart disease suggest that neuregulin 1, a human growth factor, can put infant heart cells on a path that mimics normal growth rather than stalling out.

To determine the effect of gastric acid suppression on the progression of chronic liver disease, Schnabl's team looked at mouse models that mimic alcoholic liver disease, NAFLD and NASH in humans.

«To really model these diseases, precisely mimicking each human mutation is critical.»

The result, reported here yesterday at the annual meeting of the American Society of Human Genetics, suggests that a drug mimicking this effect could prevent heart disease, a major killer.

These animals naturally develop type 2 diabetes in ways that mimic the human progression of the disease.

This mouse model for AIDS dementia mimics several features of the disease process found in humans.

She works under the direct supervision of Dr. Lamba to conduct research to develop strategies to restore vision in mouse models generated to mimic human retinal degeneration diseases.

Researchers have used CRISPR to develop a pig model of Huntington's disease that better mimics how the disease progresses in humans.

Since 2006 when Biomedcode was established, we have evaluated hundreds of therapeutics including novel biologics, biosimilars, biobetters and small molecules using a unique array of animal disease models closely mimicking the complexity of human inflammatory conditions.

Until such time as we can precisely mimic human and animal biology, and their diseases and treatments, either on a computer or using some other kind of substitute, animal research will continue to be vital to medical advancement.

Loss of NEU1 also accelerated the disease process in mice bred to mimic early - onset Alzheimer's in humans.

With all stages of clinical Lyme disease having previously been described in nonhuman primates, this animal model was selected in order to most closely mimic human infection and response to treatment.

The fruit flies developed normally but later began staggering as if mimicking humans with the disease, and died early.

Oxybenzone — This substance has been shown in studies to be a potent hormone disruptor, mimicking estrogen within the human body and potentially leading to diseases such as breast cancer, endometriosis, decreased sperm count, and prostate and testicular cancers.

A study that examines the effects of the Fasting Mimicking Diet on humans with Crohn's Disease, an autoimmune disease the affects the digestive system, are currently unDisease, an autoimmune disease the affects the digestive system, are currently undisease the affects the digestive system, are currently underway.

Healthy humans who underwent cycles of the Fasting Mimicking Diet had lower risk factors that were associated with cardiovascular disease and diabetes, such as lowered blood pressure, reduced CRP (a marker of inflammation in the blood), and reduced fasting blood glucose levels.