Sentences with phrase «mimic human infection»
With all stages of clinical Lyme disease having previously been described in nonhuman primates, this animal model was selected in order to most closely mimic human infection and response to treatment.
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The LPS was given at a time point that approximates the stage of brain development in humans right at the time of birth, thus mimicking the development of a bacterial infection during delivery.
The mouse model mimics aspects of the infection in humans, with high levels of the virus seen in the mouse brain and spinal cord, consistent with evidence showing that Zika causes neurological defects in human fetuses.
The work was completed in mouse models that mimic infection, stroke or trauma in humans.
The team of researchers harvested hematopoietic stem cells from three macaques prior to SHIV infection of all six animals in the study, treated the animals with anti-retroviral therapy (ART) to reduce viral load and mimic the situation in human HIV - infected patients who are treated with ART, and then exposed the three monkeys from which they had collected hematopoietic stem cells to a high dose of radiation.