Sentences with phrase «misfolding normal»
He and colleagues at the University of California, San Francisco, injected the brains of mice with prions they had created in the lab by misfolding normal prion protein, known as PrP.
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A small but growing cohort of scientists suspects that if this style of misfolding is a generic property of proteins, it's likely to play a role in normal biology.
For reasons not yet understood, the misfolding nature of prions is associated to their ability to sequester their normal counterparts and induce them to misfold as well.
Other researchers caution that it is not yet known whether misfolding occurs under normal conditions in healthy cells.
This abnormality can then be propagated from cell to cell because, when the misfolded version touches the normal one, it can trigger the same misfolding, thus causing the newly insoluble prions to clump.