Sentences with phrase «missing heritability»
The phrase "missing heritability" refers to the inability to fully explain or understand how inherited traits or characteristics are passed down from parents to offspring. Even though certain genes are known to be responsible for certain traits, there are still many cases where these genes cannot account for all of the inherited traits. This gap in knowledge is referred to as "missing heritability." Full definition
This puzzle has been called the «missing heritability problem.»
sciencedaily.com
Despite the proliferation of GWAS, the associations found so far have largely failed to account for the known effects of genes on complex disease — the problem of «missing heritability.»
They suggest that epigenetics could partly solve the mystery of «missing heritability» — that is, the absence of any apparent link between genetic makeup and certain normal hereditary traits and diseases.
Taylor and Ehrenreich, however, found that higher - order interactions of five or more places along the genome can have major impacts, and may help explain the so - called «missing heritability» problem, in which additive genetic variants do not entirely explain many inherited diseases and traits.
The major role that genetic variation of rDNA appears to have and the fact that rDNA analysis would not have been included in these studies could explain some of this missing heritability.
Pugh added that the implications of this research could represent one step towards solving the problem of «missing heritability» — a concept that describes how most traits, including many diseases, can not be accounted for by individual genes and seem to have their origins in regions of the genome that do not code for proteins.
Harvard University genetic epidemiologist Peter Kraft says the study adds to others in the last 3 years that have dampened hopes that if researchers could find the «missing heritability,» or all the genes that raise the risk of a particular disease, then genetic tests could help predict which patients will get sick.
Take the missing heritability problem, for example.
«This is a crucial point for genetic researchers, as there has been a lot of controversy in human genetics about what is called «missing heritability»,» explains Scharf.
However, one reason among many others could be the heterogeneity of subjects with T2DM next to the polygenetic nature of the disease, missing heritability or that important biological factors including sex, age and ethnicity were neglected in many studies.
One possible explanation was that rare variants, which are largely untested by high - density SNP arrays, might account for some of that missing heritability.
The reasons for this «missing heritability» are a subject of vigorous debate in the scientific community.
This «missing heritability» component has led to the conclusion that some forms of IBD — especially the familial forms — could be due to the profound effect of rare variants whose causes are yet to be discovered.