Sentences with phrase «mitochondrial dynamics»

The molecular machinery of mitochondrial dynamics was first described in yeast and then the corresponding pathways found in mammals and humans.

Defective mitochondrial dynamics have been implicated in cancer, cardiovascular disease, neurodegenerative diseases, diabetes and chronic kidney disease.

A dysregulation of these mitochondrial dynamics and abnormal morphology (shape) of these mitochondrion are hallmarks of aging and thought to contribute to many degenerative diseases such as Alzheimers and Parkinsons.

Lewis, in 1914 observed that «Any one type of mitochondria such as a granule, rod or thread may at times change into any other type» through the processes now known as mitochondrial dynamics.

This is called mitochondrial dynamics.

He has studied the role of mitochondrial dynamics in neuronal apoptosis and neurodegeneration, and for the past five years bioenergetics and mitochondrial dysfunction in neurodegenerative disease models and mechanisms of insulin secretion in pancreatic beta cell models.

Also changes in the shape of mitochondria, a phenomenon known as mitochondrial dynamics, is a mechanism of energy adaptation in changing metabolic conditions, to adjust the needs of cells.

To determine whether defects in the mitochondrial dynamics of this small nucleus of POMC neurons could cause alterations in metabolism, researchers removed a mitochondrial dynamics protein, Mitofusin 1, from these cells in mice.

Karbowski, Mariusz, et al. «Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis.»

April 10th — Aleem Siddiqui, Ph.D., University of California - San Diego Title: Mitochondrial dynamics, innate immunity in viral hepatitis

At the Buck, he will analyze the effects of mitochondrial dynamics on age - related dysfunction in adult stem cells.

Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: Relevance to lung cancer.

As a postdoc, Nunnari was among the first to use GFP to visualize mitochondria in yeast, and helped establish the field of mitochondrial dynamics.

Chemical genetics unveils a key role of mitochondrial dynamics, cytochrome c release and IP3R activity in muscular dystrophy.

Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons.

In particular, we want to decipher the impact of mitochondrial dynamics and ultra-structure on OXPHOS functionality and mitochondrial performance by imaging the relevant processes on the single organelle and single molecule level in human cells.

Reduced mitochondrial activity is associated to altered mitochondrial dynamics in Down syndrome cells

Researchers from the Institut Pasteur, CNRS and Inserm, in collaboration with a team from Switzerland, have discovered a previously unknown mechanism by which L. pneumophila targets mitochondria to modulate mitochondrial dynamics and thereby impairs mitochondrial respiration which in turn leads to a change in the cellular metabolism.

First, mild endoplasmic reticulum stress and impaired calcium release seriously disturbed mitochondrial dynamics, thus providing an explanation as to why alterations in the endoplasmic reticulum could lead to impaired mitochondrial dynamics.

«Mitochondrial dynamics impair nervous system development in Wolfram syndrome.»

Although mitochondria, the tiny capsules that produce energy for the cell, are known to play some role in neurodevelopmental and psychiatric disorders, the contribution of mitochondrial dynamics (mitochondrial trafficking, the regulated fusion and fission, and destruction of mitochondria) has been less clear.

Not exact matches

A) OXPHOS functionality is affected by multiple interrelationships: mitochondrial ultrastructure, dynamics, metabolic needs and quality control.

Manganese suppresses ATP - dependent intercellular calcium waves in astrocyte networks through alteration of mitochondrial and endoplasmic reticulum calcium dynamics.

This is an interesting and important paper for basic understanding of mitochondrial DNA dynamics and the etiology of mitochondrial disease.

For example, by engineering PA - GFP tagged to a mitochondrial matrix protein (mito - PAGFP) the Youle Lab was able to visualize and quantify the fusion dynamics of mitochondria in healthy and apoptotic cells (9).