What was also very interesting about the study was that increased
mitochondrial efficiency of the cell (needing less oxygen), apparently is owed to the lower levels of proteins... proteins that normally make the mitochondria «leaky» and inefficient.
Their work builds upon and may potentially supersede several previous approaches to the problem
of mitochondrial mutations that occur as a result
of the degenerative aging process, including allotopic protein expression, (6) its optimization using an MTS, (3 - 5) and the exploitation
of the multiprotein RNA import complex (RIC)
of the protozoal parasite Leishmania tropica (7)(which the investigators characterize as «requir [ing] the introduction
of nonnative tRNAs with foreign protein factors or the transfer
of a large multisubunit aggregate into
cells, which is
of low
efficiency and difficult to reproduce in desirable disease - relevant settings» (2)-RRB-.