Sentences with phrase «mitochondrial enzymes»

Promastigotes with reduced LMIT1 activity showed growth defects and were more susceptible to ROS toxicity, consistent with a role of iron as an essential co-factor of mitochondrial enzymes called superoxide dismutases that detoxify ROS.

Influence of endurance exercise training and sex on intramyocellular lipid and mitochondrial ultrastructure, substrate use, and mitochondrial enzyme activity

The researchers performed the studies using mice bred to carry gene alterations that disrupt the production of the same mitochondrial enzyme that is defective in patients with MMA.

Previous studies into Friedreich's ataxia have investigated the direct effect of frataxin deficiency on mitochondrial enzymes that contain iron - sulphur clusters, but with a focus on nerve cell mitochondrial defects once symptoms had already been detected and the disease diagnosed.

NAC is a powerful antioxidant that helps fight the effects of free radicals formed by inefficient mitochondrial enzymes.

• Increased turnover, metabolism, and loss of this vitamin in urine or sweat • Increased mitochondrial enzymes that require more biotin for cofactors • Increased need for tissue repair and maintenance • Increased food intake requiring biotin for metabolism

They cause an alteration in gene expression, leading to a suppression of key mitochondrial enzymes, like carnitine palmitoyltransferase — which finally solves the mystery of why those eating vegetarian have a 60 % higher expression of that fat - burning enzyme.

Alpha - Lipoic acid (LA) is a disulfide compound that is produced in small quantities in cells, and functions naturally as a co-enzyme in the pyruvate dehydrogenase and alpha - ketoglutarate dehydrogenase mitochondrial enzyme complexes.

Mercury also blocks mitochondrial enzymes, creating an overproduction of reactive oxygen species, including free radicals.

The results of the study revealed that fennel seed essential oil had strong antifungal activities, and seemed to be better than the commonly used antifungal remedies, fluconazole and amphotericin B. Further research indicated that fennel oil could also obstruct the activities of mitochondrial enzymes, like succinate dehydrogenase and malate dehydrogenase.

The researchers then modeled a new system with the same process: the mitochondrial enzyme ATP synthase, which also exhibits a distinct conformational change that is dictated by the application of force to the enzyme structure, which is propagated via tensegrity.

Two mitochondrial enzymes — pyruvate carboxylase (PC) and glutaminase replenish carbon to the Krebs cycle.

«We also showed that TCL1 inhibits a mitochondrial enzyme required for in oxidative phosphorylation, leading to a reduction in oxygen consumption of the cells,» co-first author Shiho Aizawa explains.

«We have identified a number of pharmaceutical compounds that selectively inhibit — in different experimental models — the mitochondrial enzyme responsible for the tumour growth, thus limiting fat synthesis and without harming normal cells.»

We are currently characterizing the aminoacylation activity of the mitochondrial enzyme seryl - tRNA synthetase (SRS).

A recent study found enhanced expression of genes encoding for mitochondrial enzymes and energy metabolism in the hippocampus, a part of the brain important for learning and memory.

The liver can not utilize ketone bodies because it lacks the mitochondrial enzyme succinyl CoA: 3 - ketoacid CoA transferase required for activation of acetoacetate to acetoacetyl CoA [3].