Sentences with phrase «mitochondrial fragmentation»
Feeding the flies stearate largely reversed the changes in their nerve function, motor control and lifespan, and fully reversed the mitochondrial fragmentation.
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They used an established genetic model of Parkinson's wherein fruit flies demonstrate mitochondrial fragmentation, neurodegeneration, impaired motor control and reduced lifespan.
The researchers then considered Parkinson's disease as a pathological condition where this process could be important, because Parkinson's disease is associated with mitochondrial fragmentation.
DRP - 1 is required for BH3 mimetic - mediated mitochondrial fragmentation and apoptosis.
S - Nitrosylation of Drp1 Mediates Mutant Huntingtin - Induced Mitochondrial Fragmentation and Neuronal Injury in Huntington's Disease.
The researchers have identified the following mechanism: L. pneumophila establishes transient, highly dynamic contacts with host mitochondria and secretes an enzyme called MitF that modifies the shape of the mitochondria by inducing DNM1L (a host protein that is necessary for fragmenting mitochondria) depended mitochondrial fragmentation.
Yoon and his research team found that glycochenodeoxycholate is a primary instigator of the rapid and sustained mitochondrial fragmentation that occurs in cholestasis and that when they blocked the excessive fission, ROS production, liver injury and scarring, which can lead to cirrhosis and loss of liver function, were all substantially diminished.
Not exact matches
Just turning on AMPK by itself gives you as much fragmentation as a mitochondrial poison,» says Shaw.
Overgrown tissue was composed of normal - sized, UCP1 - negative unilocular adipocytes, with mitochondrial network fragmentation, disorganised cristae, and increased autophagosomes.
Moreover, glutamine supplementation has a protective effect in the DNA fragmentation, mitochondrial membrane depolarization and apoptosis, and in regulation of the inflammatory process and immune suppression, which are induced by a single session of exercise.