The mitochondrial pathway of cell death (apoptosis) starts by permeabilization of
the mitochondrial outer membrane which becomes peppered with small holes.
ATP is transported through further barrel pores across
the mitochondrial outer membrane into the cytosol, which fuels life of human cells.
Subsequently, the sorting and assembling machinery (SAM) was identified in
the mitochondrial outer membrane, which is required for the insertion of the barrel proteins.
Not exact matches
Tom40 forms a channel in the
outer mitochondrial membrane that is used to import proteins.
«As a postdoc in my lab, she discovered the first direct connection between the preprotein translocases of the
mitochondrial outer and inner
membranes and showed the dynamic behavior of
mitochondrial membrane translocases,» Pfanner writes in an e-mail to Science Careers.
The intrinsic pathway drives cell death by permeabilization of the
outer mitochondrial membrane and is regulated by the Bcl - 2 oncogene family of pro- and antiapoptotic factors.
In addition to glycolysis, acetyl - CoA is produced from the oxidation of fatty acids by acyl - CoA synthetase enzymes in the
outer mitochondrial membrane, and then transported into the inner
mitochondrial matrix by acetyl L - carnitine for β oxidation and ATP production.
The fats in VISTA work to fix the
outer and inner
membranes, support
mitochondrial function, and influence learning, sleep, thermoregulation and pain threshold.