When the
mitochondrial translation rate increases, the mTOR signaling pathway is activated, which causes the increase in the cytoplasmic
protein translation rate to counteract pressure from the increased
mitochondrial translation, thus representing a new evolutionary adaptation mechanism.
The mutations that underlie the mitochondriopathies Myoclonic Epilepsy with Ragged Red Fibers (MERRF) and some variants of
Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike Episodes (MELAS) create defective versions of particular mitochondrial amino acid tRNAs, leading to inefficient translation of electron transport system (ETS) subu
Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike Episodes (MELAS) create defective versions of particular
mitochondrial amino acid tRNAs, leading to inefficient translation of electron transport system (ETS) subu
mitochondrial amino acid tRNAs, leading to inefficient
translation of electron transport system (ETS) subunit
proteins.