Sentences with phrase «mitochondrial targeting sequence»
GenSight Biologics» pipeline leverages two core technology platforms, the Mitochondrial Targeting Sequence (MTS) and optogenetics to help preserve or restore vision in patients suffering from blinding retinal diseases.
https://www.gensight-biologics.com/
Rosella is targeted to the cytosol when expressed without a signal sequence and to the mitochondria via citrate synthase's mitochondrial targeting sequence.
Therefore, Teitell's group opted to further modify their constructs with a 3 ′ - UTR mitochondrial targeting sequence (MTS) from human mitochondrial ribosomal protein S12 — the same essential approach used to optimize the import of allotopically - expressed proteins by Dr. Marisol Corral - Debrinski, (3,4) and subsequently advanced for multiple additional ETS subunit proteins by Dr. Matthew O'Connor's group at the SENS Foundation Research Center (RC).
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In addition, it binds to the promoter sequences (dark blue) of specific target genes including mitochondrial fission process 1, MTFP1.
Targeted sequencing improves Neandertal mitochondrial DNA retrieval and reveals low diversity among individuals.