Sentences with phrase «mitochondrial uncoupling»

These compounds aren't just hard to pronounce, they're hard for our cells to tolerate and lead to mitochondrial uncoupling, DNA damage, free radical cascades and other cell - damaging events that accelerate the aging process and contribute to disabling disease.

Human Skeletal Muscle Mitochondrial Uncoupling Is Associated with Cold Induced Adaptive Thermogenesis.

Obesity - related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2.

Not exact matches

This is what one would hope and is very promising, suggesting that in the majority of cases, mitochondrial and nuclear inheritance can be successfully uncoupled.

Salicylanilides are very lipophilic and may shuttle protons across membranes, particularly the inner mitochondrial membrane, thus removing the proton gradient and uncouple oxidative phosphorylation [6, 7, 15].

Their gene expression profile revealed striking up - regulation of peroxisome proliferator - activated receptor gamma coactivator 1alpha (an up - regulator of mitochondrial biogenesis not normally expressed in white fat), increased uncoupling proteins - 1 and -2, and down - regulation of lipogenic enzymes.

Electron microscopy showed dose dependent mitochondrial changes following indomethacin administration consistent with uncoupling of oxidative phosphorylation (or inhibition of electron transport) which were indistinguishable from those seen with the uncoupler dinitrophenol.

Electron microscopy showed mitochondrial damage following NSAID (indomethacin) compatible with uncoupling of oxidative phosphorylation and inhibition of electron transport.

Electron microscopy shows dose dependent mitochondrial changes that are indicative of uncoupling of oxidative phosphorylation or inhibition of electron transport.