Sentences with word «mitogenic»

While there is a long - held theoretic belief of an increased risk of cancer, based on the growth hormone's antiapoptotic and mitogenic effects, neither long - term nor short - term data support this theory.

This is an example of simple mitogenic stimulation that has been in place since the 30s.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

HGF induces mitogenic and anti-apoptotic activity in different systems 150, 151, 152 and has a well - characterized role in wound repair 153, 154, 155, effects that are consistent with a role for MSC in regenerative medicine.

Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex.

Cellular senescence is often fueled by nuclear DNA damage followed by chronic DDR activation; telomere shortening, mitogenic oncogenes, or intrinsic DNA damage can lead to different types of senescence limiting the replicative lifespan of cells.

«There are other membrane - bound proteins that transmit mitogenic (proliferation) signals in cells,» he said.

In a new STEM CELLS Translational Medicine study, Zhang et al. now report that the overexpression of Platelet - Derived Growth Factor - BB (PDGF - BB), a well - known potent mitogenic, angiogenic, and chemoattractive agent, can significantly enhance dental tissue regeneration [5].

These acquired cellular changes which transform normal cells to become malignant include the ability of cells to generate their own mitogenic signals, resist growth - inhibitory signals, evade apoptosis, acquire vasculature, and proliferate without limits.

In addition to p53, there are other transcriptional activatory mechanisms that are not well understood for the most part and which operate in response to mitogenic stimulation (11, 12), transforming growth factor - β (13, 14, 15), and aberrant oncogenic signals (16, 17) or during a number of cell differentiation processes (18, 19).

I should mention that this pathway is also responsible for activating the mitogenic pathway.

But this gives you a good overview of two major pathways that are regulated by insulin: one is called the metabolic pathway, or the PI - 3 kinase pathway; and the other is the mitogenic pathway, or the MAP kinase pathway.

Magnesium is mitogenic (causes cell division) in osteoblasts (the major cellular component of bone) and magnesium depletion inhibits cellular growth.

Apparently you didn't read any of the information that I posted, my contention was that while IGF - 1 is a factor in metastasis, its signaling depends on its receptor expression which determines its mitogenic effects and it can't be said that if vitamin D levels and metabolism are sufficient to reduce receptor expression when appropriate an increase in IGF - 1 levels would lead to a greater risk for developing a cancer.

For example, studies of medical students facing examinations and kindergarten children beginning school reveal changes in immune functioning potentially prognostic for adverse health outcomes, including changes in numbers of total t - lymphocytes, natural killer cell cytotoxicity, and lymphocyte responsivity to mitogenic stimulation (e.g., 8, 9).