Sentences with word «mitotane»

The lecture will address the advantages and disadvantages of mitotane and trilostane.

Adrenal tumors can also be treated with mitotane at high doses and for a long period of time.

Treatment for Cushing's is with a medication called mitotane.

It isn't nearly as toxic as mitotane (Lysodren Rx), which is the other approved treatment for hyperadrenocorticism (Cushing's disease).

Finally, treatment of Cushing's disease with the drugs mitotane and trilostane can result in complete adrenal destruction and Addison's disease in some dogs.

Trilostane vs. Mitotane North Carolina Veterinary Conference, Raleigh, North Carolina, November 4, 2011.

The lecture will also review how to transition safely between mitotane and trilostane when indicated.

Since Mitotane selectively destroys the adrenal gland, the risk of too much destruction should be considered and is always a possibility.

She completed a master's degree in biomedical sciences with research on the effects of trilostane and mitotane on aldosterone in canine Cushing's disease.

Dogs with this atypical disorder generally respond to drugs like mitotane or trilostane, similar to dogs with typical or classical Cushing's disease.

Mitotane powders and liquids sprinkled on food with a little corn oil is an effective way to give the drug.

Mitotane decreases the body's ability to handle stress.

Kintzer PP, Peterson ME: Mitotane treatment of 32 dogs with cortisol - secreting adrenocortical neoplasms.

Treatment for a tumor on the dog adrenal glands includes surgery and the use of a medication called mitotane.

Most dogs with hyperadrenocorticism can be treated with drugs such as mitotane (Lysodren ™) or trilostane (Vetoryl ™).

Prior to initiation of mitotane, the clinical signs should be consistent with a diagnosis of hyperadrenocorticism and the diagnosis should be confirmed.

A more recent study found a survival rate of 900 days for dogs treated with twice daily trilostane, versus 720 days for dogs treated with mitotane.

Trilostane vs. Mitotane?

Pets with high blood potassium levels, or those with, or at risk for, Addison's disease (hypoadrenocorticism) or diabetes Use with caution in pets with kidney or liver disease Pets taking the drug mitotane (treatment for Cushing's disease) Pregnant and nursing pets Pets known to have had an allergic reaction to spironolactone Directions:

The problem can be treated medically with compounds that reduces the production of cortisone (mitotane, trilostane) or, in some cases, surgically.

Mitotane (Lysodren) is used to destroy the adrenal tissue producing the excess cortisol.

When treating a pituitary dependent form of canine cushing's disease, an adrenolytic agent called mitotane is used.

Lysodren (mitotane) pills are a «sure thing» because they destroy the adrenal glands, thus stopping the oversupply of steroids.

Mitotane is often successful in controlling clinical signs and in some cases may also result in tumor shrinkage.

The advantage of Mitotane is, in the majority of cases, mitotane produces excellent control of clinical signs associated with Cushing's.

Mitotane has disadvantages as well.

Mitotane should never be administered to animals that are not eating well.

In the unfortunate circumstance of an adrenal tumor, treatment involves either surgical resection of the tumor or medical therapy with mitotane, trilostane, or ketoconazole.

In patients who are not polydipsic, patients in which water consumption can not be monitored, and patients in which polydipsia is due to another underlying disease (eg, diabetes mellitus), mitotane should be administered for a maximum of 5 - 7 days prior to testing.

In dogs that fail to respond to mitotane or dogs that do not tolerate the drug, the next choice of therapy is Trilostane.

The current treatment of choice for pituitary - dependent Cushing's is chemotherapy with op - DDD (mitotane, Lysodren ®).

Mitotane should be administered for up to 10 days, until water consumption decreases to < 100 mL / kg / day, or until a decreased appetite, depression, diarrhea, or vomiting are observed.

Some dogs with inoperable tumors or metastatic disease may respond to medical treatment with high doses of op - DDD (mitotane).

Mitotane has a number of unwanted side effects.

A less expensive - but not as effective - way to treat your ferret is with mitotane (Lysodren), which must be given orally every three or four days.

If calcinosis cutis is the problem it will be necessary to try to adjust the dosage of mitotane (Lysodren Rx) to better control the Cushing's disease or to consider switching to one of the other treatments.

Peterson ME: O, p» - DDD (mitotane) in the treatment of canine pituitary - dependent hyperadrenocorticism.

Mitotane (Lysodren) and trilostane (Vetoryl) are oral medications that selectively destroy part of the adrenal cortex so that although the pituitary gland tumor continues to release ACTH, cortisol levels remain normal.

Mitotane must be given in high doses until it starts to work.