The estimates of the variance components suggest that
the mode of inheritance of hip dysplasia is quantitative, with a major gene affecting the trait jointly with numerous minor genes.
The mode of inheritance of a condition affects a breeding plan.
The mode of inheritance of the other types is not yet known.
The latter fact can cast doubt on the calling of male heterozygotes by this method and could possibly lead to the results shown in studies testing
the mode of inheritance of ridgelessness.
The exact
mode of inheritance of LPD has been debated among researchers.
Various
modes of inheritance of epilepsy have been deduced in different breeds, including simple autosomal recessive 3 with a sex - modifier 4, 5, polygenic recessive 6 with a sex - predilection 7, polygenic with a large contribution by a single autosomal recessive gene 8, and a multi-locus model 9.
Not exact matches
The words Santayana uses here are «substantial
inheritance» and «lateral tension,» The first is the
mode of passage
of natural moments into their successors, the second is the mutual pressure on each other
of contemporary natural moments which influences what each thus passes into.
To the contrary, our normal experience has a focused center washed over by a series
of vaguely discriminated backgrounds, any one
of which can snap to the center
of attention given appropriate stimuli, and I hold that it is my model
of dominant and oblique
inheritance and not his model
of regionally inclusive
inheritance which most adequately reflects this normal
mode of awareness.
In the twentieth century, such research has relied almost exclusively on perception in the
mode of presentational immediacy, that is, on quantified sense data devoid
of a sense
of past
inheritance and thus devoid
of meaning, emotion or purpose.
And so their
mode of inheritance is largely one
of conformity to the past, that is to say,
of efficient causation.
Instinct is «the
mode of experience directly arising out
of the urge
of inheritance...» Intellect is the
mode of experience arising from the entertainment
of ideals.
In a commentary accompanying the report, Paul Soloway
of Cornell University remarks: «A particularly intriguing possibility is that such RNAs regulate other non-genetic
modes of inheritance, such as metabolic or behavioral imprinting.»
This Venn diagram, generously provided by Kari Branham
of the University
of Michigan, shows RP genes associated with different
modes of inheritance.
The Orphanet Rare Disease Ontology (ORDO) is an open - access ontology developed from the Orphanet information system, enabling complex queries
of a rare disorder and its epidemiological data (age
of onset, prevalence,
mode of inheritance) and gene - disorder functional relationships.
ORDO also represents the relationship between the disorders and their genetic cause (if known), the
mode of inheritance and associated epidemiological data (age
of onset, age
of death, prevalence).
Holobionts and their hologenomes: Evolution with mixed
modes of inheritance — Karen Luisa Haag — Genetics and Molecular Biology
Investigated models
of speciation between diploid and tetraploid Mercurialis annua species, according to the timing
of whole genome duplication, their
mode of inheritance and population size changes
The results can be filtered by quality,
mode of inheritance (e.g. autosomal, homozygous recessive, compound heterozygous, etc.), population frequencies and known and expected pathogenicity according to ClinVar database and several predictors.
Some reasons for this relatively low yield include unappreciated phenotypic heterogeneity; locus heterogeneity; somatic and germline mosaicism; variants
of uncertain functional significance; technically inaccessible areas
of the genome; incorrect
mode of inheritance investigated; and inadequate communication between clinicians and basic scientists with knowledge
of particular genes, proteins, or biological systems.
Heredity plays a role in SA, although the
mode of inheritance is not yet understood.
This study is designed to determine the incidence
of SCC in the listed breeds, to determine the
modes of inheritance and identify DNA variants that put horses at risk for this cancer.
This study is designed to determine the incidence
of BCSL in the breed, to determine the
mode of inheritance if a single gene is involved, and identify candidate genes for further investigation.
Renowned ophthalmologist Dr Kirk Gelatt from the University
of Florida is heading an on - going research study to isolate the gene, determine
mode of inheritance and hopefully develop a test.
Little is known about the
mode of inheritance; that is, whether they are simple as progressive retinal atrophy and sebaceous adenitis are in some breeds or are, like hip dysplasia, a complex association
of many genes.
This will enable clarification
of the
mode of inheritance.
While the exact
mode of inheritance is unknown, it is probably polygenetic.
The
mode of inheritance for most Aussie cataracts is dominant with incomplete penetrance, meaning not every dog with the mutation will develop cataracts though 70 %
of those with cataracts have it.
Research at the University
of Helsinki identified the causative gene in 2007, showing an autosomal recessive
mode of inheritance.
The evidence was in support
of a simple autosomal recessive in that breed and it is not improbable that the same
mode of inheritance occurs in other breeds.
No
mode of inheritance has been identified in breeds thus far studied.
Included in this process is an understanding
of the
modes of inheritance.
The
mode of inheritance for PRA varies with the breed.
Many
of the traits and diseases that are
of interest to breeder seem to have a polygenic
mode of inheritance (HD, heart disease, etc.) which means that many genes are involved.
Heart murmurs are believed to be inherited through a polygenic
mode of inheritance.
It is difficult to control disorders with a polygenic
mode of inheritance as the exact genes which cause such a disease and the non-genetic factors which will influence expression are unknown.
The
mode of inheritance is unknown, but this condition is minor in comparison to other health issues.
Although the
mode of inheritance is recessive, male dogs born from a carrier female require just one copy
of the mutation, the other gene linked to the X chromosome from which disease gets its name.
It must be noted however that a subset
of PRA - affected Italian Greyhounds in the study carried only one copy
of the IG - PRA1 risk allele, suggesting that the disease may represent a
mode of inheritance called «Autosomal Dominant with Incomplete Penetrance» (ADIP).
Dramatic, complete and immediate removal
of carriers from a closed / highly related population such as Italian Greyhound's would definitely not be recommended if we were certain
of an Autosomal Recessive
mode of inheritance.
The occurrence
of patellar luxation in certain breeds suggests a genetic influence, but the
mode of inheritance is unknown; there is a possibility the defect is polygenic.
Further research by Dr. Nicholas Dodman into the genetics suggests a dominant
mode of inheritance for this condition.
Pidduck et al., (3) working with toy poodles, proposed a simple (autosomal) recessive
mode of inheritance.
Systemic histiocytosis
of the Bernese Mountain Dog has a polygenic (many genes involved)
mode of inheritance.
Therefore, the disease is limited primarily to male dogs due to the sex - linked
mode of inheritance.
In an effort to clarify the
mode of inheritance, Vasseur et al., (5) working with the Manchester terrier club, conducted a test breeding.
Regardless
of the exact
mode of inheritance, statistical analysis
of this and other studies reveals that LPD has a high degree
of heritability.
One recommendation is clear, regardless
of the
mode of inheritance: Two dogs carrying at least one copy
of the IG - PRA1 risk allele should not be bred together.
Where there is a relatively simple
mode of inheritance, and where there is a DNA test widely available, controlling an inherited disease may be relatively straightforward.
To do a better job, one most know the
modes of inheritance for each trait.
They are understating your breed's standard, knowing the
modes of inheritance that effect the traits to be eliminated or improved and knowing what the strengths and weaknesses are that present in your pedigrees.