Sentences with phrase «mode of inheritance with»

In contrast, an autosomal dominant mode of inheritance with a high degree of penetrance has been suggested for the pulverulent (dust - like) form of cataract observed in the Norwegian Buhund [116] and autosomal dominant with variable penetrance has been suggested for inherited posterior polar subcapsular cataracts in the Labrador and Golden retriever [117], although current anecdotal evidence indicates that in the Labrador cataracts could also be inherited as an autosomal recessive trait.

The abundance of carriers in the population caused initial difficulties in characterizing the mode of inheritance with certainty and it was suspected that the disease had an autosomal dominant mode of inheritance.

Analysis of pedigrees from 4005 Bernese mountain dogs with 50 affected dogs revealed a polygenic, recessive mode of inheritance with a predisposition for males 7.

Not exact matches

This Venn diagram, generously provided by Kari Branham of the University of Michigan, shows RP genes associated with different modes of inheritance.

Holobionts and their hologenomes: Evolution with mixed modes of inheritance — Karen Luisa Haag — Genetics and Molecular Biology

Some reasons for this relatively low yield include unappreciated phenotypic heterogeneity; locus heterogeneity; somatic and germline mosaicism; variants of uncertain functional significance; technically inaccessible areas of the genome; incorrect mode of inheritance investigated; and inadequate communication between clinicians and basic scientists with knowledge of particular genes, proteins, or biological systems.

The mode of inheritance for most Aussie cataracts is dominant with incomplete penetrance, meaning not every dog with the mutation will develop cataracts though 70 % of those with cataracts have it.

The mode of inheritance for PRA varies with the breed.

It is difficult to control disorders with a polygenic mode of inheritance as the exact genes which cause such a disease and the non-genetic factors which will influence expression are unknown.

It must be noted however that a subset of PRA - affected Italian Greyhounds in the study carried only one copy of the IG - PRA1 risk allele, suggesting that the disease may represent a mode of inheritance called «Autosomal Dominant with Incomplete Penetrance» (ADIP).

Pidduck et al., (3) working with toy poodles, proposed a simple (autosomal) recessive mode of inheritance.

In an effort to clarify the mode of inheritance, Vasseur et al., (5) working with the Manchester terrier club, conducted a test breeding.

With polygenic disorders, or those with an unknown mode of inheritance, breadth of normalcy in the pedigree is the best selection tWith polygenic disorders, or those with an unknown mode of inheritance, breadth of normalcy in the pedigree is the best selection twith an unknown mode of inheritance, breadth of normalcy in the pedigree is the best selection tool.

The vertical pedigrees were drawn and scrutinized to see whether the phenotypes and the assumed genotypes in each generation were compatible with expectations under assumptions of the simple Mendelian modes of inheritance.

Various modes of inheritance of epilepsy have been deduced in different breeds, including simple autosomal recessive 3 with a sex - modifier 4, 5, polygenic recessive 6 with a sex - predilection 7, polygenic with a large contribution by a single autosomal recessive gene 8, and a multi-locus model 9.

This mode of inheritance means that one affected dog crossed with one normal dog will produce puppies of which half, on average, will have the disease.

The estimated segregation ratio is not consistent with a fully penetrant simple autosomal recessive mode of inheritance.

Epilepsy in beagles was thought to be homologous to Lafora's disease in man based on the similar findings from histopathological examination 23 and the mode of inheritance was described as autosomal recessive with a sex - linked «suppressor» 4, 5.

The mode of inheritance has not been determined precisely but the fact that dogs heterozygous for the KRT71 mutation do not have curls and also the occasional occurrence of dogs with curly hair in breeds with typically straight hair suggests that the curly hair is inherited in a recessive or incompletely dominant mode.

This is a condition which is thought to be inherited, probably with a polygenic mode of inheritance modified by environmental influences.

Modes of inheritance for these diseases are not fully known and are likely to be complex, with multiple genes involved.

In contrast, the form of cataract observed in the Australian Shepherd, caused by the deletion described above, has a dominant, or co-dominant mode of inheritance, is not completely penetrant and is typically associated with a posterior polar subcapsular cataract that also has a variable age of onset.

Dogs are born with it and it is inherited, although the mode of inheritance is not yet known in our breed.

EIC is a hereditary condition with an autosomal recessive mode of inheritance.

The mode of inheritance has been determined to possibly be, autosomal recessive in Keeshonds16, polygenic with one gene of major influence in Belgian Tervurens17, and polygenic recessive in Golden Retrievers.18 Once the mode of inheritance is determined within a breed, we will determine the best technique to try and find a genetic marker linked to epilepsy gene (s) in each breed.

The estimates of the variance components suggest that the mode of inheritance of hip dysplasia is quantitative, with a major gene affecting the trait jointly with numerous minor genes.

Depending on the particular variety, the mode of inheritance could be autosomal recessive or dominant, or X-chromosome-linked recessive or dominant, some with full penetrance, and some not.

While variability in the age of disease onset and incomplete pedigree information preclude us from drawing any definitive conclusions about the mode of inheritance, the available data is most consistent with an autosomal recessive pattern.

Although the definitive mode of inheritance is often difficult to estimate from pedigrees due to missing phenotypes, our pedigrees in all breeds suggest a strong genetic influence with multiple affected dogs across generations and even within several litters.

Hip dysplasia is an inherited defect with a polygenic -LRB-» many genes») mode of inheritance.