Sentences with phrase «model disease»

But perhaps most exciting, many researchers say, is their ability to model diseases in new ways.

He sees the day when his simulations could be modified to model disease transmission through casual contact, shopping on a crowded street, or pedestrian safety at a traffic intersection.

For example, the same cellular signals that guide early heart development can be used to direct stem cells to become the different heart cell types needed for modeling disease in a dish.

During his doctoral research, he pioneered the use of bile duct organoids to model diseases of the biliary system, test multiple drugs, and identify new therapeutic agents.

It's now possible to not only model disease using the cells, but also to compare iPSCs from humans to those of our closest living relatives --- great apes, with which we share a majority of genes --- for insight into what molecular and cellular features make us human.

When the scientists modeled disease transmission, they found that while an «infected person's 11 nearest neighbors faced a greater than 80 percent chance of infection,» Wired reports, «all the remaining passengers, however, had a lower than 3 percent risk.»

Using data from 23 sites, Winifred Frick, an ecologist at Boston University, helped model the disease's impact on little brown bats.

Gatenby began trying to mathematically model the disease to work out how best to tackle it.

Now, a team of scientists at the Icahn School of Medicine at Mount Sinai have developed the Just EGFP Death - Inducing T - cell, or JEDI T - cells, which enable the visualization of T - cell antigens, allowing researchers to study T - cell interactions with different cell types, model disease states, and finally determine the functions of otherwise poorly characterized cell populations.

«To really model these diseases, precisely mimicking each human mutation is critical.»

Last year, Gladstone scientists announced a promising new drug candidate that prevents memory deficits and the loss of synaptic connections between brain cells — key features of Alzheimer's — in mice modeling the disease.

Screening for potential therapeutics in rodent models of AD has generally relied on testing compounds before pathology is present, thereby modeling disease prevention rather than disease modification.

This discovery, which earned Dr. Yamanaka the 2012 Nobel Prize in Physiology or Medicine, has revolutionized the fields of stem cell biology and regenerative medicine and has allowed scientists to model disease from patient - derived cells in a dish, thus working towards a new era of personalized medicine.

The use of nonhuman primates to model this disease provides the most accurate representation of human Lyme disease as demonstrated in this work.

To model the disease architecture of T2D, the authors conducted an elegant experiment.

Gage's lab also models diseases in the laboratory using human stem cells.

Now scientists regularly use iPSCs to model diseases using cells that would be otherwise difficult to obtain from a living person or animal.

The ability to grow organoids allows scientists to use these three - dimensional mini-organs for modeling disease, screening drugs and potentially even replacing defective tissue.

Mathematicians are addressing some of our world's most urgent challenges — including tackling climate change, modelling disease transmission and solving the human genome sequence.

Aside from a regenerative therapy to replace ailing organs, the scientists add that the NPCs could be used to model diseases in the lab.

To demonstrate the chip's efficacy in modeling disease, the team doped different regions of the brain with the drug Phencyclidine hydrochloride — commonly known as PCP — which simulates schizophrenia.

«Stem cells used to model disease that causes abnormal bone growth.»

The two papers also clarify uncertainty around which methods are best for stem cell engineering, and should advance the use of cells derived from patient tissues to model disease, test potential drugs and use as treatments.

They can be used to model diseases, and in the future could be used to test drugs or even replace damaged tissue in patients.

Those tests don't give us the details we need to understand the nature of the pathology at the cellular level, so we modeled the disease to perform a systematic analysis of the optic nerve, from its origin in the eyes to termination in the brain.»

Using leukemia as a model disease, the team looked for therapeutically exploitable attack points on the protein and they actually identified such.

«Micro heart muscle created from stem cells: New technique offers cheaper, faster method to create heart tissue for testing drugs and modeling disease.»

The tissue can be used to model disease and test drugs, and it opens the door for a precision medicine approach to treating heart disease.

Researchers at Indiana University School of Medicine have successfully developed a method to grow inner ear tissue from human stem cells — a finding that could lead to new platforms to model disease and new therapies for the treatment of hearing and balance disorders.

Progenitor cells grown from the skin of ALS (Lou Gehrig's disease) or spinal muscular atrophy patients can be transformed into various neural cells to model each disease and allow rapid drug screening, Zhang adds.

Clevers and other scientists have developed organoids of the gut, liver, lung, brain, and many other human organs that can be used to model disease or to serve as test beds for drugs.

The process can also be used to model disease.

Progenitor cells grown from the skin of ALS or spinal muscular atrophy patients can be transformed into various neural cells to model each disease and allow rapid drug screening.

In this study, induced pluripotent stem (iPS) cells, which have the potential to differentiate into any type of cell in the body, were used to model the disease.

New technique offers cheaper, faster method to create heart tissue for testing drugs and modeling disease

The differentiation of patient - specific induced pluripotent stem cells (iPSCs) into has the potential to provide differentiated cells to test drugs, model diseases, and, most importantly, to replace lost or damaged tissues.

This technology produces induced pluripotent stem cells, or iPS cells, that offer amazing promise for the future of modeling disease, discovering and testing new therapies in the laboratory, and ultimately repairing damaged hearts.

They used yeast cells to model the disease, which allowed them to look at over 5,000 genes to map out which ones caused more or fewer cells to die.

His lab develops isogenic human pluripotent stem cells and transgenic animals to model disease, with the goal of delineating novel approaches to influence outcomes for Huntington disease (HD) and Fragile X Syndrome (FXS), the most common genetic causes of dementia and intellectual disability, respectively.

In our model disease, multiple myeloma, we aim to discover molecular mechanisms of the pivotal transition from its premalignant precursor state to the active malignant stage.

Host: Dr. Matt Farrer Speaker: Dr. Richard Wade - Martins, Univ. of Oxford Title: Translating Parkinson's: modelling disease for target discovery

Instead, Huang decided to use human cells to model the disease and test new drugs.

He found that expression was elevated only in beta cells both in humans with type 2 diabetes and in mice that model the disease.

These constructs simulate three - dimensional models of organs and could be used to discover and develop new drugs, model diseases, and, ultimately, directly repair, restore, and replace organs damaged by injury or disease — all vital aspects of regenerative medicine.