Sentences with phrase «model disease states»

Now, a team of scientists at the Icahn School of Medicine at Mount Sinai have developed the Just EGFP Death - Inducing T - cell, or JEDI T - cells, which enable the visualization of T - cell antigens, allowing researchers to study T - cell interactions with different cell types, model disease states, and finally determine the functions of otherwise poorly characterized cell populations.

Not exact matches

Maine statute directed the committee to develop this model policy based on the current research and best practice guidelines from the national Centers for Disease Control and Prevention and other states» concussion management documents.

To account for potential overlap among hypertension, diabetes, and MI, we modeled transitions over time between comorbid disease states using a first - order Markov process.

All models assumed steady - state rates of disease and mortality.

The response in Newburgh was crafted in consultation with the U.S. Centers for Disease Control and Prevention and will serve as a national model for understanding PFOS exposure, state Department of Health spokesman James Plastiras said.

Others on the team include a veterinary epidemiologist and an economist from Kansas State University, and a disease spread model designer.

Induced pluripotent stem cells (iPSCs)-- adult cells reprogrammed back to an embryonic stem cell - like state — may better model the genetic contributions to each patient's particular disease.

The disease model, described in a new study by a UC San Francisco - led team, involves taking skin cells from patients with the bone disease, reprogramming them in a lab dish to their embryonic state, and deriving stem cells from them.

The prevalence model, developed by RTI for the United States Centers for Disease Control and Prevention, illustrates some of issues the nation will face as diabetes rates increase and Americans live longer.

Using experimental models and state - of - the - art technology, the scientists found that switching off this protein leads to better control of glucose production from the liver, revealing a potential new target that may be used to treat type 2 diabetes and other metabolic diseases.

Application of sun protection factor 30 (SPF30) sunscreen prior to exposure to ultraviolet - B (UVB) light delayed melanoma onset in a mouse model of the disease, according to data from a team at The Ohio State University Comprehensive Cancer Center Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

Eran Andrechek, a physiology professor in the College of Human Medicine at Michigan State University, has discovered that many of the various models used in breast cancer research can replicate several characteristics of the human disease, especially at the gene level.

Mice bred to carry a gene variant found in a third of ALS patients have a faster disease progression and die sooner than mice with the standard genetic model of the disease, according to Penn State College of Medicine researchers.

Their data were used to create a model that shows the potential effects of temperatures and temperature change on the transmission of dengue, chikungunya and Zika around the world, three diseases that are mosquito - vectored and increasing in the United States.

Colorado State University biologists say this sporadic ebb and flow of prairie dog plague is an ideal model for the study of rare infectious zoonotic disease — disease that can jump from wildlife to humans — like MERS (Middle East Respiratory Syndrome) and Ebola.

When Zobair Younossi, MD, MPH, of Inova Fairfax Hospital in Virginia, and his colleagues constructed models to assess the potential burden of NAFLD, they estimated that there are 64 million individuals with the disease in the United States and 52 million in the four European countries examined (Germany, France, Italy, and the United Kingdom).

In collaboration with the United States Department of Agriculture (USDA), researchers in the UPV / EHU's «Nutrition and Obesity» Group, which belongs to the Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERobn) of the Carlos III Institute of Health, have observed in animal models that its administration reduces the build - up of body fat, which could reduce the risk of developing other diseases like diabetes.

Researchers at Penn State University have developed an innovative technology to regenerate functional neurons after brain injury, and also in model systems used for research on Alzheimer's disease.

Researchers at Penn State University led by biologist Gong Chen have developed an innovative technology to regenerate functional neurons after brain injury, and also in model systems used for research on Alzheimer's disease.

The construction of the University Technology Center is the next step to enabling Penn State College of Medicine to utilize «big data» to enhance patient care through disease modeling and predictors for disease by more efficiently processing and analyzing clinical information.

The Chronic Social Defeat Stress (CSDS) mouse model has received much interest recently as it closely mimics the dynamic range of individual responses to stressors such as the development of a major depressive disorder, anxiety, post-traumatic stress disorder or resil ¬ iency to these disease states.

Our aim is to develop a multi-scale mathematical model (ranging from the molecular to the organ scale) of the liver tissue that can predict alterations of organ function consequent to molecular perturbations and disease states.

Investigators in the CRGGH will develop genetic epidemiology models that will explore the patterns and determinants of common complex diseases in populations in the United States and other human populations around the world.

A key early development was establishment at the Ohio State University of a SMA mouse model that recapitulates the human disease.

(6) Based on what is known about the behavior of the antibody and the available pharmacokinetic data, Prothena CEO Gene Kinney has stated (albeit without presenting modeling to support the assertion) that «we would expect to fully saturate that pathological load [of aggregated AS] in patients with Parkinson's disease.»

In our model disease, multiple myeloma, we aim to discover molecular mechanisms of the pivotal transition from its premalignant precursor state to the active malignant stage.

Our in vitro study provides a baseline for defining healthy and disease - like states and highlights the power of moving beyond single and dual species applications to capture key players and their orchestrated metabolic activities within a complex human oral microbiome model.

Brian O. Ma & Bernard D. Roitberg — 2008 (8)([email protected]) Keywords: Aedes aegypti, Anopheles gambiae, dynamic state variable model, foraging behaviour, mosquitoes, omnivores, resource availability, state - dependence, vector - borne disease control

Recently, mouse neural stem cells (NSCs) have been shown capable of reprogramming into a pluripotent state by forced expression of Oct3 / 4 and Klf4; however it has been unknown whether this same strategy could apply to human NSCs, which would result in more relevant pluripotent stem cells for modeling human disease.

Researchers at Penn State College of Medicine, working with Chinese and American colleagues, have discovered a novel way to enhance and restore cancer suppressor activity in B - cell acute lymphoblastic leukemia, resulting in better outcomes in a pre-clinical model of the disease.

Experimental approach: To use patient - specific induce pluripotent cell models from a (i) storage disease (NCL), (ii) aggregate prone disease (ALS) and (iii) a disease with no aggregates but hyperexcitability (ChAc) combined with state of the art live cell imaging techniques, electrophysiology and biophysical tools (PIV, laser ablation for cortex tension measurements, AFM).

Gage and Ghosh discuss how human skin cells induced to return to an immature state («induced pluripotent stem cells» or IPS cells) are revolutionizing our understanding and treatment of mental and neurodegenerative disorders, such as Parkinson's disease, as well as leading to new models of drug development for all diseases.

«Infectious disease can mean making trade - offs between the risks and rewards of meeting others,» says Eli Fenichel, Arizona State University assistant professor and co-organizer of a transdisciplinary working group at NIMBioS that has developed a better model for understanding the role human decisons play in the spread of disease.

By developing a simple chemically defined culture system permitting efficient differentiation of numerous human iPS cell lines toward cells of a mature hepatic state, we now demonstrate the possibility of modeling groups of diseases of non-neuronal origin whose phenotypes are a consequence of complex protein dysregulation within adult cells.

As each person takes responsibility for their own personal evolution, then human beings as a collective can move beyond the materialistic model and the creation of greater disease states.

«There's been a major paradigm shift in the teaching of PE,» says Lawler, whose program has been highlighted in the state and national media and has been identified by the federal Centers for Disease Control and Prevention as a national model.

J. Lidicker MA et al, Lyme Disease Cases in the United States Projected Through 2012: Time Series Model Identification and Forecasts of the Federal CDC Data.

Diuk - Wasser, M. A., G. Vourc» h, P. Cislo, A. G. Hoen, F. Melton, S. A. Hamer, M. Rowland, R. Cortinas, G. J. Hickling, J. I. Tsao, A. G. Barbour, U. Kitron, J. Piesman, and D. Fish, 2010: Field and climate - based model for predicting the density of host - seeking nymphal Ixodes scapularis, an important vector of tick - borne disease agents in the eastern United States.

C40 Cities Climate Leadership Group, 12 California, 7, 68, 102, 128, 169 - 170, 187, 196, 232 - 234, 245 California Energy Commission, 232 Cambridge Media Environment Programme (CMEP), 167 - 168 Cambridge University, 102 Cameron, David, 11, 24, 218 Cameroon, 25 Campbell, Philip, 165 Canada, 22, 32, 64, 111, 115, 130, 134, 137, 156 - 157, 166, 169, 177, 211, 222, 224 - 226, 230, 236, 243 Canadian Meteorological and Oceanographic Society (CMOS), 15 Cap - and - trade, 20, 28, 40 - 41, 44, 170, 175 allowances (permits), 41 - 42, 176, 243 Capitalism, 34 - 35, 45 Capps, Lois, 135 Car (see vehicle) Carbon, 98, 130 Carbon Capture and Storage (CCS), 192 Carbon Capture and Storage Association, 164 Carbon credits (offsets), 28 - 29, 42 - 43, 45 Carbon Cycle, 80 - 82 Carbon dioxide (CO2), 9, 18, 23, 49 - 51, 53, 55, 66 - 67, 72 - 89, 91, 98 - 99, 110, 112, 115, 118, 128 - 132, 137, 139, 141 - 144, 152, 240 emissions, 12, 18 - 25, 28 - 30, 32 - 33, 36 - 38, 41 - 44, 47, 49, 53, 55, 71 - 72, 74, 77 - 78, 81 - 82, 108 - 109, 115, 132, 139, 169, 186, 199 - 201, 203 - 204, 209 - 211, 214, 217, 219, 224, 230 - 231, 238, 241, 243 - 244 Carbon Dioxide Analysis Center, 19 Carbon Expo, 42 Carbon, footprint, 3, 13, 29, 35, 41, 45, 110, 132 tax, 20, 44, 170 trading, 13, 20, 40, 43, 44, 176, 182 Carbon monoxide (CO), 120 Carbon Reduction Commitment (CRC), 44 Carlin, George, 17 Carter, Bob, 63 Carter, Jimmy, 186, 188 Cato Institute, 179 CBS, 141, 146 Center for Disease Control, 174 Center for the Study of Carbon Dioxide and Global Change, 62, 139 Centre for Policy Studies, 219 CERN (European Organization for Nuclear Research), 96 Chavez, Hugo, 34 Chicago Tribune, 146 China, 29, 32 - 33, 60 - 62, 120, 169, 176, 187 - 188, 211, 216, 225 - 226, 242 - 243 China's National Population and Planning Commission, 33 Chinese Academy of Sciences, 60 Chirac, Jacques, 36 Chlorofluorocarbons, 42 - 43, 50 Choi, Yong - Sang, 88 Christy, John, 105 Churchill, Winston, 214, 220 Chu, Steven, 187 Citibank (Citigroup), 40, 176 Clean Air Act, 85, 128 - 129 Clean Development Mechanism, 42 Climate Action Partnership, 14 Climate alarm, 4, 13, 21, 32, 35, 38, 56, 102 - 103, 115 - 117, 120, 137, 156, 168, 173, 182 Climate Audit, 66 Climate change, adaptation, 39, 110, 112 mitigation, 16, 39, 110 Climate Change and the Failure of Democracy, 34 Climate Change: Picturing the Science, 121 Climate Change Reconsidered, 242 Climate conference, 38 Cancun, 18, 29, 36 - 37, 124 - 125, 242 Copenhagen, 33, 36, 109, 125, 156, 158, 175, 241 - 242 Durban, 13, 36 - 37, 166, 242 - 243 Climategate, 2, 67, 152, 158 - 170, 180, 182, 242 Climate Protection Agreement, 12 Climate Research Unit (CRU), 48, 67, 120, 147, 152 - 153, 158 - 160, 162 - 163, 165 - 167, 169 Climate Science Register, 142 Climatism, definition, 2, 7 Clinton, Bill, 176, 178 Clinton Global Initiative, 176 CLOUD project, 96 Club of Rome, 21, 186 CO2Science, 59, 61 - 62, 66, 131 Coal, 19 - 20, 39 - 41, 80, 126, 128 - 129, 175, 185 - 186, 188 - 190, 192 - 196, 199 - 201, 209, 214, 217, 219, 222, 229 Coase, Ronald, 145 Coca - Cola, 138 Cogley, Graham, 156 Cohen, David, 220 Colorado State University, 117, 181 Columbia University, 7 Columbus, Christopher, 58 Computer models, 16, 51 - 53, 56, 67, 72, 74,77 - 79, 82, 87, 89 - 91, 94, 105, 110 - 111, 120, 124, 138 - 140, 168, 171,173, 181, 238, 240, 246 Conference on the Changing Atmosphere, 15 Consensus, scientific, 12 Copenhagen Business School, 134 Coral, 53 Corporate Average Fuel Economy, 22 - 23 Cosmic Rays, 72, 93 - 99, 180 Credit Suisse, 176 Crow, Cheryl, 30 Crowley, Tom, 167 Cuadrilla Resources, 224 - 225 Curry, Judith, 164, 167 Cycles, natural, 3, 16, 57, 62 - 63, 66 - 69, 72, 80, 99, 103, 138, 238, 240 Milankovich, 62, 67, 80 Cyprus, 134 Czech Republic, 12, 37

The model predicted, according to the Times, «by the end of May, there would only be 2,000 to 2,500 cases in the United States... On May 15, the Centers for Disease Control and Prevention estimated there were upwards of 100,000 cases in the country...»

The pharmaceutical business model has typically focused on health conditions that affect large populations at the expense of disease states that affect fewer people.

Public Health Leadership Initiative National Center for Injury Prevention and Control, Centers for Disease Control and Prevention Describes a 3 - year project to identify best practice models of State public health leadership in preventing child maltreatment and promoting safe, stable, and nurturing relationships for children.

According to this model, thoughts, beliefs, attributions and expectations play a key role in the perception of disease - related symptoms, such as pain, and in how people adjust to them.64 The underlying process advocates a strong link between such cognitions and emotional state, physical symptoms and behaviours.