Sentences with phrase «model disease using»

It's now possible to not only model disease using the cells, but also to compare iPSCs from humans to those of our closest living relatives --- great apes, with which we share a majority of genes --- for insight into what molecular and cellular features make us human.

Now scientists regularly use iPSCs to model diseases using cells that would be otherwise difficult to obtain from a living person or animal.

Not exact matches

As we begin to access God's power to defeat the Sin - disease and discover and use our own legitimate power to live, we step into the spiritual world, where God shares the keys to life and reality (A Hunger for Healing: The Twelve Steps As a Classic Model for Christian Spiritual Growth [NY: HarperCollins, 1991], pp. 4 - 6).

We can not use his model to predict the outcome of any experiment, design a tool, cure a disease or describe natural phenomena with mathematics.

Comparing different policy scenarios to reduce the consumption of ultra-processed foods in UK: impact on cardiovascular disease mortality using a modelling approach

More broadly, updated longitudinal studies of the natural history of hypertension, diabetes, and cardiovascular disease are needed, because the data from the National Health and Nutrition Examination Survey that we used in our model are somewhat dated.

To account for potential overlap among hypertension, diabetes, and MI, we modeled transitions over time between comorbid disease states using a first - order Markov process.

This is demonstrated in the studies reviewed in the special issue, which use computational models to examine brain processes, such as learning, emotion, dopamine signaling and information processing, and how processes interact in deficits underlying psychiatric disease.

Protein misfolding and aggregation had been identified as a major factor in mad cow disease, and research using yeasts as model organisms played a large role in those findings.

Benjamin «Benjy» Firester, 18, of New York City, won the top award of $ 250,000 for developing a mathematical model that uses disease data to predict how weather patterns could spread spores of late blight fungus, which caused the Irish Potato Famine.

The company provides porcine models of particular diseases, models that are used to develop gene - based treatments and drugs.

«The whole value of model organisms is that they are lean and mean,» so once he has established his proofs of principle, ideally he will be able to use a matrix approach to efficiently tackle many rare diseases simultaneously.

For researchers using mouse models to study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with disease progression.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in general.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

«I had been thinking about model organisms for a very long time in academia, and when I started to realize that there were all these people clamoring for their rare diseases I thought, «Why aren't people using model organisms to study them?

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

Thomas is a wildlife biologist by training, but he now uses technology such as satellite remote sensing and software applications such as geographic information systems to model vector disease transmission.

Exposed to both air and fluid, the cells might also be used to model the lungs and test drugs for lung disease.

The researchers are beginning to use their model to test whether Zika virus, and other pathogens associated with congenital disease, can infect placental cells and / or cross the placental barrier.

«Using that approach, can we screen for guide RNAs that have unusually strong protective activities in a model of neurodegenerative disease.»

Using iPSCs, researchers developed a novel cellular disease model to probe the neurobiological causes of schizophrenia, which are not well understood (ChangHui Pak, abstract 032.29, see attached summary).

They can also be used to create novel disease models from which new drugs and therapies can be developed.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

Zebrafish are commonly used to model human diseases, in part because their larvae are transparent, making it easy to see the effects of genetic mutations or drugs.

When the weather - based model developed at Rothamsted Research was used to predict how climate change may affect the wheat crops, it was predicted that wheat flowering dates will generally be earlier and the incidence of the ear blight disease on the wheat crops will substantially increase.

«Social media data have been suggested as a way to track the spread of a disease in a population, but there is a problem that in an emerging outbreak people also use social media to express concern about the situation,» explains study team leader Sherry Towers of ASU's Simon A. Levin Mathematical, Computational and Modeling Sciences Center.

This proof - of - principle study shows «for the first time... that human iPS cells can be used to model a diverse range of inherited diseases in adult cells,» the authors wrote in their paper, published online in The Journal of Clinical Investigation August 25.

Satellite imagery is used for all sorts of climate study, from identifying conditions that allow infectious diseases like West Nile virus and cholera to emerge, to creating models for predicting hurricanes, to distinguishing natural resources such as wind, water and sunlight.

For the research, the scientists used the platform to target colon macrophages in order to reduce inflammatory symptoms caused by Inflammatory Bowel Disease (IBD) in mouse models.

Realistic stem cell therapies to replace diseased or damaged tissue may still be years away, but researchers have uncovered a promising new use for these undifferentiated cells: they can be programmed to become patient - specific laboratory models of inherited liver disease.

The UT Southwestern group had previously used CRISPR - Cas9, the original gene - editing system, to correct the Duchenne defect in a mouse model of the disease and in human cells.

This weather - based model was then used to predict the impact on severity of the disease of future weather scenarios for the period from 2020 to 2050.

«We know that urate has neuroprotective properties in animal models, and an unusual convergence of human studies suggested its possible use as a disease - modifying strategy in Parkinson's; so the positive results of this trial are very encouraging.»

Using data from 23 sites, Winifred Frick, an ecologist at Boston University, helped model the disease's impact on little brown bats.

The research team also screened candidate drugs using a «disease - in - a-dish» model.

Using animal models of precancerous polyps in the bowel, Chung and his team determined that certain types of immune cells within a chronically inflamed intestine can become rewired, causing them — paradoxically — to contribute to disease development rather than protect against it.

By coupling a machine learning model with a patient's pulse data, they are able to measure a key risk factor for cardiovascular diseases and arterial stiffness, using just a smart phone.

She and her colleagues will be exploring the role of YY1 further, using clinical samples as well as mouse models, to look at the protein in diseases like lupus to deepen their understanding of how autoimmunity could result from the «escape» of immune genes from X chromosome inactivation.

Bocinsky and d'Alpoim Guedes are using the modeling technique to identify little - used or in some cases completely forgotten crops that could be useful in areas where warmer weather, drought and disease impact food supply.

We can use this model to study how the skin barrier develops normally, how the barrier is impaired in different diseases and how we can stimulate its repair and recovery.»

Now that the team has generated the tools necessary to rapidly manipulate killifish, the model organism can be used to screen for genes and drugs that slow or reverse aging and age - related diseases.

Stem cell models, derived from healthy or diseased cells, are also being developed for use in drug efficacy and toxicity testing.

This is particularly important as it indicates the method can be used in a variety of cell types to create disease models and contribute to the discovery of new disease - specific therapeutics.

Both of the advantages point toward a possibility of using this new method for regenerative therapies and for creating models of rare diseases for future studies and individualized health care.

Using CRISPR / Cas9, the Hamon Center team was able to correct the genetic defect in a mouse model of DMD and thus prevent the development of features of the disease, which in boys causes progressive muscle weakness and degeneration, often along with breathing and heart complications.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

Their previous research, which used an inducible model of periodontal disease, found that Cp40 could reduce signs of the disease.

«This computational model might be used to predict other life - threatening episodes of diseases,» Chen said.

«This study, carried out using laboratory rats modeling stroke, demonstrated that ischemic stroke — in both its subacute and chronic stages — damages the BSCB in a variety of ways, creating a toxic environment in the spinal cord that can lead to further disability and exacerbate disease pathology,» said study lead author Dr. Svitlana Garbuzova - Davis, associate professor in USF's Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair.