Sentences with phrase «model diseases in»

Aside from a regenerative therapy to replace ailing organs, the scientists add that the NPCs could be used to model diseases in the lab.

But perhaps most exciting, many researchers say, is their ability to model diseases in new ways.

For example, the same cellular signals that guide early heart development can be used to direct stem cells to become the different heart cell types needed for modeling disease in a dish.

Gage's lab also models diseases in the laboratory using human stem cells.

Not exact matches

In order to value bitcoin and predict future prices, analysts at Barclays came up with a model that likens it to an infectious disease.

The role that big pharma plays in research, while valuable, is often tenuous, because profit models for many diseases are not always apparent, at least in the short term.

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

We combine artificial intelligence with automation to conduct experimental biology at scale — testing thousands of compounds on hundreds of cellular disease models in parallel.

Kogan wrote in the email that he wanted to create statistical models that could accurately identify people at risk for various diseases and illnesses by examining their Web browsing and purchase behaviors, and combine that with medical data from Harvard.

[111] Cf. Jim D. Broadfoot, Richard C. Rosatte, and David T. O'Leary, «Raccoon and Skunk Population Models for Urban Disease Control Planning in Ontario, Canada,» Ecological Applications 11, no. 1 (2001).

«Future studies need to determine the health effects of these cocoas in models of human disease and to evaluate the consumer acceptability of the cocoas as part of a chocolate product.»

Comparing different policy scenarios to reduce the consumption of ultra-processed foods in UK: impact on cardiovascular disease mortality using a modelling approach

Graduated models are more common, since they are excellent in preventing and treating most circulatory diseases found in the limbs.

More broadly, updated longitudinal studies of the natural history of hypertension, diabetes, and cardiovascular disease are needed, because the data from the National Health and Nutrition Examination Survey that we used in our model are somewhat dated.

Although the observational studies that underlie our models all adjusted for multiple confounders, including known risk factors for the disease outcomes of interest, risk factors for early breastfeeding cessation such as preterm birth, preeclampsia, and obesity are also risk factors for metabolic disease in later life.

Of note, our models may underestimate the true maternal costs of suboptimal breastfeeding; we modeled the effects of lactation on only five maternal health conditions despite data linking lactation with other maternal health outcomes.46 In addition, women in our model could not develop type 2 diabetes mellitus, hypertension, or MI before age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some studies have found an association between lactation and rates of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and MIn addition, women in our model could not develop type 2 diabetes mellitus, hypertension, or MI before age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some studies have found an association between lactation and rates of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and Min our model could not develop type 2 diabetes mellitus, hypertension, or MI before age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some studies have found an association between lactation and rates of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and MI.

Potential confounding factors associated with diarrhoeal disease (p < 0.10) were included in a multivariate model where infant feeding was the main exposure.

The Dr Hadwen Trust for Humane Research claims that «in some instances, reliance on inaccurate animal «models» of human disease have undoubtedly delayed medical progress.»

The response in Newburgh was crafted in consultation with the U.S. Centers for Disease Control and Prevention and will serve as a national model for understanding PFOS exposure, state Department of Health spokesman James Plastiras said.

The SUV members talked in detail about treating violence as a disease and why their model program is successful.

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot - Marie - Tooth disease type 2A

«I'm interested in bridging gaps between traditional epidemiology and mathematical modeling, hopefully developing improved methods for studying infectious diseases,» she says.

This is demonstrated in the studies reviewed in the special issue, which use computational models to examine brain processes, such as learning, emotion, dopamine signaling and information processing, and how processes interact in deficits underlying psychiatric disease.

«It would be interesting to model some of these diseases in mice and see if supplementing NMN provides any benefit to their behavior or memory.»

Protein misfolding and aggregation had been identified as a major factor in mad cow disease, and research using yeasts as model organisms played a large role in those findings.

The researchers, including first author Matheus Victor, PhD, a postdoctoral research associate, set out to generate neurons that would mimic those of adult patients in order to model the onset and progression of Huntington's disease.

«It started to become quite evident to me that a research career in infectious disease epidemiology and mathematical modeling would be a fairly perfect combination of my longstanding interests in math and biology and medicine, as well as my emerging interest in infectious disease transmission and public health more generally,» she says.

«In theory, we could model progression of the disease by reprogramming skin cells from patients at a range of ages, including before symptoms begin.

Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a mouse model of the disease — potentially laying the groundwork for a new approach to treating severe cases of human depression in which drugs are ineffective.

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

Human tissue grown in the laboratory offers a critical model for understanding the disease process.

To develop their «disease in a dish» model, the team took skin cells from patients with Allan - Herndon - Dudley syndrome and reprogrammed them into induced pluripotent stem cells, which then can be developed into any type of tissue in the body.

In an e-mail to Nature a few days later, Kogan said that zebrafish might be a useful model organism for psychiatric disease after all.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in generaIn the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in generain people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in generain general.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

Scientists for the first time have assembled a «disease in a dish» model that pinpoints how a defect in the blood - brain barrier can produce an incurable psychomotor disorder, Allan - Herndon - Dudley syndrome.

«I had been thinking about model organisms for a very long time in academia, and when I started to realize that there were all these people clamoring for their rare diseases I thought, «Why aren't people using model organisms to study them?

«We knew that the brain hat was a very high potential» among marchers, says Chris Pierret, a biologist at the Mayo Clinic in Rochester, but his group commissioned crocheted zebrafish hats, honoring one of their favorite disease research models.

Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study of molecules to treat cancers caused by human herpes virus infection in mice models of disease.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

BIG BAT, LITTLE BAT New models that consider bat size in relation to white - nose syndrome indicate that smaller bats like the North American little brown bat, Myotis lucifugus (shown), may be more susceptible to the disease and will struggle to survive future winters.

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

Currently, I work on three directions: (1) cell motility and the cytoskeleton, (2) modeling of physiology and diseases (such as autoimmune diabetes), and (3) swarming and aggregation behaviour in social organisms.

The study of these highly unusual but devastating prion diseases has to date been thwarted by a lack of animal models that faithfully mimic the disease processes in humans.

«Gene - delivery system prevents vision loss from inherited eye disease: Initial testing in animal models holds promise for treating Leber congenital amauroisis and other congenital visual disorders.»

«The fact that a [cell] culture expresses most genes present in the brain says nothing about its appropriateness as a disease model,» says Knoblich.

«Using that approach, can we screen for guide RNAs that have unusually strong protective activities in a model of neurodegenerative disease.»

«Now we have two interesting models that are selectively targeting specific parts of the brain: the thalamus in FFI and the hippocampus in CJD,» says Jackson, who is now a Group Leader at the German Center for Neurodegenerative Disease.

To study the pathogenesis of HIV - induced PNS disease, Jamie Dorsey, Research Technologist, and the research team led by Dr. Mankowski developed a simian immunodeficiency virus (SIV)- infected macaque model that closely reflects key peripheral nervous system (PNS) alterations seen in HIV patients with peripheral neuropathy.