Sentences with phrase «model during disease»

Not exact matches

In order to test their hypothesis in a model that more closely mimicked human disease, the researchers also tested the two drugs side - by - side on slices of tumors removed from patients during radical prostatectomy.

In mouse models of disease, Yale researchers looked at the effects of providing nutrients during infection and found opposing effects depending on whether the infections were bacterial or viral.

The new finding is the latest evidence supporting a growing precision medicine model of psychiatric disease in which disruptions of certain genes during brain development contribute to a person's risk for multiple psychiatric disorders, with other genetic or epigenetic drivers, random developmental events, or environmental influences determining the specific disease an individual develops, said senior author Benjamin Cheyette, MD, PhD, an associate professor of psychiatry and a member of the UCSF Weill Institute for Neurosciences and the Kavli Institute for Fundamental Neuroscience at UCSF.

The new test allowed them to observe how interactions between synapses and astrocytes change over time, as well as during various diseases, in mouse models.

For the paper, «Transmission dynamics and control of Ebola Virus Disease (EVD) outbreak in Nigeria, July - September, 2014,» published today in Eurosurveillance, researchers used epidemic modeling to project the size of the outbreak in Nigeria if control interventions had been implemented during various time periods after the initial case and estimated how many cases had thus been prevented by early initiation of interventions.

By incorporating social norms into predictive mathematical modelling, a research team from the University of Guelph and the University of Waterloo found that they can foresee the observed patterns of population behavior and disease spread during vaccine scares — times when anti-vaccine sentiment is strong.

Many of these devices resemble sleeker, more efficient models of instrumentation used by research labs to record brain activity during sleep, physiological changes during stress, migraine triggers, activity levels and even early symptoms of debilitating neurological diseases.

Hoping to develop a treatment that works more broadly across diseases, a Penn Vet team used canine disease models to closely examine how retinal gene activity varied during the progression of three different forms of inherited vision disease.

Additionally, the wheel lock and other animal model suggest that exercise during youth may help preserve muscle mass over the course of aging and lower the activity of genes associated with cardiovascular disease.

Human embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD), as well as the conversion of somatic cells, such as skin fibroblasts, into induced pluripotent stem cells by genetic manipulation, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

During its Preparatory Phase, INFRAFRONTIER aimed at resolving the major issues required for implementing a sustainable INFRAFRONTIER Research Infrastructure for systemic phenotyping, archiving and distribution of mouse models of human diseases:

We aim to comprehensively annotate functional elements, decipher genomic codes of transcription, as well as coding and non-coding gene function during development and enhance zebrafish as an attractive developmental, comparative and disease model.

«During the next 10 years,» says Svendsen, «we're going to see a trend away from using animals for disease modeling and using human cells with iPS technology instead.»

Together, our results suggest a comprehensive model of chromatin dynamics during development and set the foundation for similar work on human blood formation and disease.

For example, using a transgenic marmoset model of Alzheimer's disease, clinicians and basic researchers are working together to identify the changes in the brain's circuitry during mild cognitive impairment and very early stages of Alzheimer's.

Yet while autism begins during brain development, and it makes sense that a developing organoid could serve as a model, looking at diseases that affect people toward the end of their lives would seem more difficult.

Curiously, in a mouse model of Alzheimer's disease, PirB serves as a receptor for the beta - amyloid protein that accumulates during the disease.

Huang and colleagues previously reported that, during sharp - wave ripples in the hippocampus, patterns of brain activity thought to occur during memory replay and consolidation, gamma waves were disrupted in a mouse model of Alzheimer's disease.

Our lab uses both cardiomyoctes derived from human stem cells (iPS cell - derived cardiomyocytes) and mouse models harboring the human mutation to study which exact changes occur during the onset and development of the disease.

The research lines of the Bakkers group include unraveling the genetics of normal cardiac development and body axis formation during development, investigating the molecular mechanisms of heart regeneration in the zebrafish and how this can be compared to heart injury in the mammals, and modeling of human (cardiac) disease in the zebrafish to unravel biological mechanisms behind the disease and to identify new drug targets.

Caroline is working on adapting the Robogut model system to the culture of the mouse microbiome, in order to study how the microbial ecosystem of mice susceptible to colorectal cancer is perturbed during disease.

Dr. Joel Kahn shares new models for preventing and reversing heart disease, the biggest cause of death in both men and women during the March 2017 Functional Forum

During last decades different models such as molecular mimicry, «bystander effect» and viral persistence were proposed as possible mechanisms that initiate the overreaction of the immune system and lead to an autoimmune disease.

Although no studies have yet examined whether maternal relationship quality during pregnancy is linked to the risk of infectious disease in the offspring, there is growing evidence from animal models that a link exists between prenatal maternal stress and a wide range of adverse health outcomes in the offspring, including immune dysfunction and infectious diseases [14,15].