As a result, they contain a complete set of the genes that resulted in that disease — representing the potential of an almost perfect disease
model for studying disease development, new drugs and treatments.
«Investigators create complex kidney structures from human stem cells derived from adults: New technique offers
model for studying disease, progress toward cell therapy.»
Reductions in biodiversity from illegal wildlife trade can have other substantial negative human health impacts, including the loss of potential sources of pharmaceuticals, experimental
models for studying disease, crop pollination and micronutrients for humans lacking alternative sources of protein.
Not exact matches
Although the observational
studies that underlie our
models all adjusted
for multiple confounders, including known risk factors
for the
disease outcomes of interest, risk factors
for early breastfeeding cessation such as preterm birth, preeclampsia, and obesity are also risk factors
for metabolic
disease in later life.
When logistic
models were stratified by the presence or absence of hypertensive
disease, only maternal age older than 34 years (odds ratio [OR], 1.4; 95 % confidence interval [CI], 1.0 - 2.0), pregnancy - associated plasma protein - A of the 95th percentile or less (OR, 1.9; 95 % CI, 1.2 - 3.1), and alpha fetoprotein of the 95th percentile or greater (OR, 2.3; 95 % CI, 1.4 - 3.8) remained statistically significantly associated
for abruption.In this large, population - based cohort
study, abnormal maternal aneuploidy serum analyte levels were associated with placental abruption, regardless of the presence of hypertensive
disease.
«I'm interested in bridging gaps between traditional epidemiology and mathematical
modeling, hopefully developing improved methods
for studying infectious
diseases,» she says.
For researchers using mouse
models to
study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious
diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with
disease progression.
In the present
study, the researchers have discovered a reason
for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune
disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a
model for autoimmune
disease in general.
Further
studies in animal
models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic
for this
disease.
«I had been thinking about
model organisms
for a very long time in academia, and when I started to realize that there were all these people clamoring
for their rare
diseases I thought, «Why aren't people using
model organisms to
study them?
«This
study is important, in part because we now have a new xenograft
model that will
for the first time allow us to apply new biomarkers to better predict
disease progression and test new therapeutics.»
As
for the Lund researchers, the method provides a tool
for studying how neurons cooperate inside a healthy brain and in animal
models with different neurological
diseases.
Scientists
study VSV, which causes acute
disease in livestock but typically does not lead to illness in people, as a
model for viruses that are harmful to humans.
«The
study results elucidate the molecular mechanisms underlying
disease progression in multiple sclerosis
models, providing a basis
for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the
study.
This proof - of - principle
study shows «
for the first time... that human iPS cells can be used to
model a diverse range of inherited
diseases in adult cells,» the authors wrote in their paper, published online in The Journal of Clinical Investigation August 25.
Satellite imagery is used
for all sorts of climate
study, from identifying conditions that allow infectious
diseases like West Nile virus and cholera to emerge, to creating
models for predicting hurricanes, to distinguishing natural resources such as wind, water and sunlight.
In addition to helping understand
disease by providing more powerful
study models, «what this technology would allow you to do is reprogram a skin cell,
for example, from a Parkinson's patient... into a pluripotent cell and then in a petri dish redirect that cell into... a neuron» to treat that patient.
«This is the first time a compound targeting Gaucher
disease has been tested in a mouse model of Parkinson's disease and was shown to be effective,» said the study's senior author, Marie - Francoise Chesselet, the Charles H. Markham Professor of Neurology at UCLA and director of the UCLA Center for the Study of Parkinson's D
disease has been tested in a mouse
model of Parkinson's
disease and was shown to be effective,» said the study's senior author, Marie - Francoise Chesselet, the Charles H. Markham Professor of Neurology at UCLA and director of the UCLA Center for the Study of Parkinson's D
disease and was shown to be effective,» said the
study's senior author, Marie - Francoise Chesselet, the Charles H. Markham Professor of Neurology at UCLA and director of the UCLA Center for the Study of Parkinson's Dis
study's senior author, Marie - Francoise Chesselet, the Charles H. Markham Professor of Neurology at UCLA and director of the UCLA Center
for the
Study of Parkinson's Dis
Study of Parkinson's
DiseaseDisease.
Both of the advantages point toward a possibility of using this new method
for regenerative therapies and
for creating
models of rare
diseases for future
studies and individualized health care.
Dr Leonardo Guasti added: «It represents an entirely new concept
for the
study of the adrenal gland as the ability to generate donor - specific and functional adrenal - like cells will facilitate the next generation of cell - based treatments
for adrenal insufficiency, the
modelling of adrenal specific
diseases, and the testing of personalised interventions on cells derived from patients.»
Most animal
studies of the
disease are conducted with laboratory mice that have been genetically engineered and bred to
model ALS, but
for this research, investigators used rats with ALS because they more accurately portray the
disease's variable course in humans.
«This
study, carried out using laboratory rats
modeling stroke, demonstrated that ischemic stroke — in both its subacute and chronic stages — damages the BSCB in a variety of ways, creating a toxic environment in the spinal cord that can lead to further disability and exacerbate
disease pathology,» said
study lead author Dr. Svitlana Garbuzova - Davis, associate professor in USF's Center of Excellence
for Aging and Brain Repair, Department of Neurosurgery and Brain Repair.
In recent years, songbirds» similarities to human vocal learning have piqued researchers» interests in using them as a functional animal
model to
study the neurological basis
for Huntington's
disease.
«Finches offer researchers a new tool with which to
study Huntington's
disease: Like humans, songbirds learn their vocalizations, suggesting they could be useful as
models for certain disorders.»
While the mouse
study does not prove a direct connection between Zika infection and microcephaly, Rossi said, it does underscore the urgent need
for effective animal
models to further
study the course of
disease and its transmission.
«The next stage would be to repeat the
study in primates, a more suitable animal
model where HIV infection induces
disease, in order to further demonstrate elimination of HIV - 1 DNA in latently infected T cells and other sanctuary sites
for HIV - 1, including brain cells,» Dr. Khalili said.
«Our work and that of our colleagues on stress and CRF have been mechanistically implicated in Alzheimer's
disease, but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long - term safety in animal models,» said the study's principal investigator and corresponding author Robert Rissman, PhD, assistant professor in the Department of Neurosciences and Biomarker Core Director for the Alzheimer's Disease Cooperative Study
disease, but agents that impact CRF signaling have not been carefully tested
for therapeutic efficacy or long - term safety in animal
models,» said the
study's principal investigator and corresponding author Robert Rissman, PhD, assistant professor in the Department of Neurosciences and Biomarker Core Director for the Alzheimer's Disease Cooperative Study (A
study's principal investigator and corresponding author Robert Rissman, PhD, assistant professor in the Department of Neurosciences and Biomarker Core Director
for the Alzheimer's
Disease Cooperative Study
Disease Cooperative
Study (A
Study (ADCS).
Although it's still unknown exactly why DHA is able to prevent the onset of lupus, the researchers said this
study provides scientists with a better
model for looking at just how much DHA is needed to ward off the environmental trigger of the
disease.
«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant
for studying a particular
disease — «makes it possible to
model dementias that affect people later in life,» says senior
study author Catherine Verfaillie of KU Leuven.
«I'm hopeful the techniques successfully used in this
study can be applied to make animal
models for other neurodegenerative
diseases,» he says.
The researchers hope their new cell lines will be a useful resource
for studying the cellular and molecular intricacies of Huntington's further, and suggest they may provide a
model for examining other
diseases of the brain that are specific to humans.
In the new
study, Lee's team tested this idea in a mouse
model of Alzheimer's
disease by raising the levels of one of two forms of neuregulin - 1 in the hippocampus, an area of the brain responsible
for learning and memory.
«We think that
for the first time, we have a mouse
model of anorexia that closely resembles the conditions leading up to the
disease in humans,» said
study leader Lori Zeltser, PhD, associate professor of pathology & cell biology and a researcher in the Naomi Berrie Diabetes Center.
For example, the investigators teamed with Fabio Cominelli, MD, PhD, a Case Western Reserve Professor and Chief of the Division of Gastroenterology and Liver
Disease, to
study a mouse
model of ulcerative colitis.
«The dog is an invaluable
model for exploring hereditary copper - storage
diseases, and observations made in this
study will benefit both canine and human patient populations.»
«The induced pluripotent stem cells we used in this
study proved to be extremely useful in
disease modelling, and they could offer an excellent platform
for drug discovery and testing new therapeutic targets
for Alzheimer's
disease in the future,» says Early Stage Researcher Minna Oksanen, the lead author of the
study.
«
For example, there is a huge amount of interest and excitement globally in growing cerebral organoids» — miniature brain - like organs that can be
studied in laboratory experiments — «from stem cells to
model human brain development and
disease mechanisms.
Future work will focus on identifying cellular targets of ampulexins, and potentially generating a useful animal
model for the
study of Parkinson's
disease treatments.
The researchers hope their
study leads to better measures
for modeling and predicting infectious
disease transmission, but there are still open questions about the human - wildlife interface of
disease.
Scientists use it as a
model organism
for studying cellular signals,
disease, and the movement of cells in response to a chemical stimulus (chemotaxis).
Colorado State University biologists say this sporadic ebb and flow of prairie dog plague is an ideal
model for the
study of rare infectious zoonotic
disease —
disease that can jump from wildlife to humans — like MERS (Middle East Respiratory Syndrome) and Ebola.
Given the rapid succession of generations in yeast, we can use it as a
model organism — and
study the mechanisms of aneuploidy in much greater detail to find out whether we can derive from it new approaches
for diagnosing and treating human
diseases.»
Using data from the US Centers
for Disease Control and Prevention (CDC) Multiple - Cause of Death Files (2006 - 2015), US Census Bureau, US Department of Agriculture Economic Research Service, Agency
for Healthcare Research and Quality, and Northeast Regional Center
for Rural Development, the
study modeled associations between county - level drug - related mortality rates and economic, social, and healthcare environments.
«Previous
studies of cardiac microtissues primarily used harvested rat cardiomyocytes, which is an imperfect
model for human
disease.»
The
study of these new mouse
models means an advance in the knowledge of
disease's development mechanisms and an opportunity to implement new therapeutic strategies
for patients.
It is worthwhile to give patients expensive new drugs that can cure their hepatitis C much earlier than some insurers are now willing to pay
for them, according to a UC San Francisco
study that
models the effects of treating the
disease early versus late in its development.
However, the
study led by Pyle found that the current methods are inefficient; they produce immature cells that are not appropriate
for modeling Duchenne in the laboratory or creating a cell replacement therapy
for the
disease.
Now OIST researchers in the Developmental Neurobiology Unit have exposed a similar syndrome in zebrafish, which are an excellent
model for studying human
diseases.
An important
model in
studying human
disease, the non-coding RNA of the canine genome is an essential starting point
for evolutionary and biomedical
studies, according to a new
study led by The Genome Analysis Centre (TGAC).
«The results of the
study are truly promising, since we were able to show
for the first time that A2A adenosine receptor antagonists actually have very positive effects in an animal
model simulating hallmark characteristics and progression of the
disease.