The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of
a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.
Not exact matches
In earlier studies involving animal
models and
human cancer cell lines, researchers found that
breast cancer spreads when three specific
cells are in direct contact: an endothelial
cell (a type of
cell that
lines the blood vessels), a perivascular macrophage (a type of immune
cell found near blood vessels), and a tumor
cell that produces high levels of Mena, a protein that enhances a
cancer cell's ability to spread.
It can efficiently introduce DNA into a
cell to be incorporated into its genetic make - up, i.e. induce high gene expression level, especially in both
human and mouse
breast cancer cell lines, and mouse
breast cancer model.
Bottom
line While research has shown some benefits with regards to ER +
breast cancer cell death and prevention of metastases within mice and cellular
models, it is recommended that
human intake should be through diet only, not supplementation.