Sentences with phrase «model human heart»
That's the promise of this half - inch - wide snake robot, seen here navigating a model human heart.
http://discovermagazine.com/
Through «heart - on - a-chip» technology — modeling a human heart on an engineered chip and measuring the effects of compound exposure using microelectrodes — Lawrence Livermore researchers hope to ensure potentially lifesaving new drugs are safe and effective while reducing the need for human and animal testing.
Through «heart - on - a-chip» technology — modeling a human heart on an engineered chip and measuring the effects of compound exposure on functions of heart tissue using microelectrodes — Lawrence Livermore National Laboratory (LLNL) researchers hope to decrease the time needed for new drug trials and ensure potentially lifesaving drugs are safe and effective while reducing the need for human and animal testing.
From a scientific point of view, it makes much more sense to use human stem cells to model human hearts.»
Not exact matches
Jesus sets the model of the human «ascent» to God — prior to death in the heart or spirit and after death in an involuntary sort of way.
In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.
Sinclair thinks that these mouse models indicate that resveratrol may be effective in preventing age - related diseases in humans, like cancer, heart disease and type 2 diabetes.
Scientists use mathematical modeling to simulate human mesenchymal stem cell delivery to a damaged heart and found that using one sub-set of these stem cells minimises the risks associated with this therapy.
The research opens the possibility of a new model organism for human heart health and the distant prospect of incorporating such a gene into humans.
The study has weaknesses — the piglets didn't truly model human CHD because they did not have heart anomalies and therefore were not actually deprived of oxygen while fetuses — only after birth.
«While it seems that genetics makes a substantial difference to the severity of the heart disease in our models, it does suggest that in humans we may be able to better diagnose heart valve disease in people with rheumatoid arthritis in the future.»
A new projector allows floating 3D objects — from a model of the heart to a talking human head — to be viewed from any angle.
Anatomical model of human heart.
«Engineered cardiac tissue model developed to study human heart.»
That's because they may have finally developed a tissue model for the human heart that can bridge the gap between animal models and human patients.
The researchers chose the pig model because pig heart size and physiology is very similar to humans.
This study was designed to use readily available agents in an accepted large - animal model of human heart attack with the goal of obtaining evidence that this treatment is ready to be moved into human clinical trials.»
The current study found that mice meant to serve as a model of ischemic human heart failure (weaker blood flow after a heart attack) had higher levels of activated, pro-inflammatory macrophages, monocytes, dendritic cells and T cells trafficking between their hearts and spleens than did control mice with healthy hearts.
The percutaneous heart pump (PHP) developed at Penn State, shown here with a model of the left ventricle of a human heart, can keep a patient's blood flowing smoothly after a heart attack.
In a Philadelphia Inquirer op - ed, he wrote that such eternal life was in our reach because «Being able to decode the human genome allows us to develop detailed models of how major diseases, such as heart disease and cancer, progress, and gives us the tools to reprogram those processes away from disease.»
Roughly 75 % of disease - causing genes in humans are also found in the fruit fly, and most of the components found in human heart cells are also found in the fly heart, thus providing a model for studying cardiovascular changes.
Researchers developed a computer model of a human heart to study whether certain drugs will help treat an abnormal heartbeat, or cause serious side effects
Dr. Bruce Conklin and colleagues from Gladstone and UC Berkeley grew beating heart tissue from stem cells, creating a model of early human heart development.
If the marriage of stem cells and CRISPR follows a similar path, it might not be long before pigs have enough Homo sapiens in them not only to grow human hearts, lungs, livers, and kidneys for transplant but also to model human diseases more closely than current lab animals do and to test experimental drugs.
Historically, researchers have generated their own lines of knockout mice to serve as models for human disease, such as heart disease or cancer.
The second model instead used cells from a human heart.
In both rat and human cells modeling those in the heart, the test chemical seemed helpful.
In an effort to improve this, we employed an alginate encapsulation strategy for human mesenchymal stem cells (hMSCs) and attached them to the heart with a biocompatible PEG hydrogel patch in a rat MI model.
Fleming researchers, using a Spondyloarthritis (SpA) mouse model have found that Tnfr2 signaling is regulating polyarthritis and a newly identified heart valve stenosis, which is a common comorbidity of SpA in human patients.
The finding, the first discovery of a so - called «master» gene for myocardial, or heart muscle, cells in an animal model, puts researchers on track for exploring the capability of homologous genes in mice and humans.
In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.
Mesenchymal stem cell - like cells derived from human placenta can improve heart function in a mouse model of myocardial infarction
Through «heart - on - a-chip» technology — modeling a human...
Dr. Nobrega has modeled the impact of mutations implicated in various human diseases, such as congenital heart defects, heart failure, cancer, type 2 diabetes, obesity, and asthma.
Development of a comprehensive system which can enrich hPSC - CMs will be ultimately useful for cell therapy for diseased hearts, human cardiac disease modeling, cardiac toxicity screening, and cardiac tissue engineering.
With this study, the scientists found that JQ1 can effectively treat severe, pre-established heart failure in both small animal and human cell models by blocking inflammation and fibrosis (scarring of the heart tissue).
We use the zebrafish model to identify genes and mechanisms that regulate normal heart development, function and regeneration, and that can contribute to cardiac diseases in humans.
The research lines of the Bakkers group include unraveling the genetics of normal cardiac development and body axis formation during development, investigating the molecular mechanisms of heart regeneration in the zebrafish and how this can be compared to heart injury in the mammals, and modeling of human (cardiac) disease in the zebrafish to unravel biological mechanisms behind the disease and to identify new drug targets.
In dramatic contrast to the poor repair outcomes for humans and rodent models such as mice, salamanders are able to completely regenerate heart tissue, whole limbs and many other tissues following injury, at any life stage.
As Franklin Templeton unveils its new Franklin LibertyShares lineup of strategic beta ETFs, Chandra Seethamraju, director of systematic modeling, Franklin Templeton Solutions, details why he believes strategic beta combines the appeal of both the research that drives active strategy and the passive approach to investment, and why the Human Factor is at the heart of his new approach.
In the past, Jung said, pacemakers for dogs were older human models, which only regulated the beating of the heart's bottom chamber.
Dr. Jung says before this breakthrough, pacemakers for dogs were older, human models, used to regulate the heart's bottom chamber.
To test whether childhood human capital also accounted for covariation between credit scores and heart age, we replicated our previous SEM model, but substituted adult human capital factors with their childhood antecedents (Fig. 5).
Comparison with a model where the covariance between credit scores and heart age is constrained to initial levels showed that human capital factors accounted for a significant source of the link between credit scores and heart age.
This structural equation model illustrates the role of human capital factors in the correlation between credit scores and heart age.
All three human capital factors were also positively associated with income (educational attainment: β = 0.39, P < 0.001; cognitive ability: β = 0.35, P < 0.001; self - control β = 0.38, P < 0.001); however, multivariate regression models revealed that all three human capital factors were associated with creditworthiness and heart age independent of income (Tables S1 — S4).
This model showed that adjusting for childhood human capital factors reduced the correlation between credit scores and heart age by 22 % (from r = − 0.247 to r = − 0.192).
It's not a mystery that PAIRS has been embraced by people of diverse faiths and backgrounds because the course addresses the very heart of what it means to be human in relationship with others humans — all of whom are living, learning, growing, struggling works in progress who most often do the best they can based on their own life experience, early models, and accessible skills.