Sentences with phrase «model kidney development»
Researchers modeled kidney development and injury in kidney organoids (shown here), demonstrating that the organoid culture system can be used to study mechanisms of human kidney development and toxicity.
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Studies in the mouse model further suggest that controlled expression of Lin28 can promote kidney development and therefore may hold clues to regeneration of damaged kidneys in adults.
Research in the laboratory of Rebecca Wingert, the Gallagher Family Associate Professor of Adult Stem Cell Research in the Department of Biological Sciences at the University of Notre Dame, has confirmed the key role of a certain small molecule in the development of kidney structures in zebrafish, a widely used model for human kidneys.
In this latest research, Mohan and his colleagues present new findings that detail the use of a synthetic, plant - derived compound — abbreviated CDDO — that was shown to effectively suppress the multiple steps of lupus development in murine models, including the onset of kidney disease.
«The development of a functional human kidney glomerulus chip opens up an entirely new experimental path to investigate kidney biology, carry out highly personalized modeling of kidney diseases and drug toxicities, and the stem cell - derived kidney podocytes we developed could even offer a new injectable cell therapy approach for regenerative medicine in patients with life - threatening glomerulopathies in the future,» said Ingber.
Knockdown of dynamin - binding protein or Tuba results in abnormal kidney development and other aberrant phenotypes in zebrafish models (middle and right panels) compared with controls (left panel).