The researchers tested their theory by
creating model membranes, some of which contained PE and / or PS, and exposing them to MP1.
After confirming that the synthetic molecules behaved similarly to natural SM by using
simple model membranes, the team next used highly sensitive single - molecule imaging to monitor the role of SMs in living cell membranes.
«Even though we only demonstrated the technique
with model membranes and single cells, this technique is translatable to biological tissue,» said Brasselet.
Most model membrane studies involving gel domain morphology and lateral organization assume the domains to be static.
Multimerizable HIV Gag derivative binds to the liquid - disordered phase
in model membranes.
Our approach to understand the structure and the function of the junctions involves studying epithelial tissues in cell culture, semi-reconstituted cell junction in cells on micro-patterned surfaces and fully - reconstituted junction in
model membranes.
Alf Honigmann, Sina Sadeghi, Jan Keller, Stefan W. Hell, Christian Eggeling, Richard Vink A lipid bound actin meshwork organizes liquid phase separation in
model membranes.
Selective inhibition of the Nav1.7 pain channel; Crystal structure of a Nav1.7 - antagonist complex viewed in
a model membrane.