Sentences with phrase «model membranes by»

Lateral sorting in model membranes by cholesterol - mediated hydrophobic matching.

Sorting in model membranes by cholesterol - mediated hydrophobic matching.

Not exact matches

Equipment manufactured by Enoveneta includes the following components: NE400 elevator, TOP 15 destemmer crusher, TSA automatic post sorting table, PEV280 peristaltic pump and membrane press model PP45 (not shown).

The researchers tested their theory by creating model membranes, some of which contained PE and / or PS, and exposing them to MP1.

The researchers began by creating large membrane models with embedded and dyed channel proteins; they then put them on a glass surface and measured them using a single - molecule measuring method known as fluorescence correlation spectroscopy.

In the final step in bacterial cell division, constriction of the so - called Z - ring, an annular structure that forms on the plasma membrane near the midpoint of the cell, gives rise to the two daughter cells: A research team led by Erwin Frey, who holds the Chair of Statistical and Biological Physics at LMU, has now used mathematical modelling to understand the mechanism that drives formation of the Z - ring, and in so doing have uncovered a novel class of pattern - forming mechanism in biological systems.

Prof. De Meyts assures that «Prof. Maruyama makes a convincing case that this [dimerization] model is incorrect, and that in fact, numerous cell membrane receptors are pre-dimerized in the membrane and are activated allosterically by ligand binding.»

«Guided by observations that show that the membrane thickness varies from pole to pole, we constructed a mathematical model that considers the egg to be a pressurized elastic shell that grows and showed that we can capture the entire range of egg shapes observed in nature,» said Mahadevan.

They then used their model to create scores of egg shapes by altering the membrane's stiffness and changing the pressure.

Shnyrova et al. (p. 1433; see the Perspective by Holz) reconstituted dynamin - mediated membrane scission on lipid nanotubes and suggest a molecular model for dynamin activity that takes into consideration all known aspects of dynamin function.

This gives a high level of flexibility for the search algorithm as well, because both general (i.e. free rotation and translation) and more specific moves (i.e. adding a new structure element to an existing model in the membrane plane) are allowed and biased by probability.

Here the authors, using an ex-vivo model, show that cancer - associated fibroblasts facilitate colon cancer cells invasion in a matrix metalloproteinase - independent manner, likely by pulling and stretching the basement membrane to form gaps.

Our global aim is to reconstruct such networks by focusing on individual components (cells, soluble factors, membrane receptors), or by integrating multiple components using systems biology and modeling.

Distinguish between models for trafficking to the lysosome by fusing Medium - FT to LAMP - 2A, a lysosome - associated membrane protein, and following its subcellular localization overtime (Subach et al..)

Dmitry: as the paper itself notes, the most likely mechanism for the ability of hydroxypropyl - β - cyclodextrin to lower Aβ burden in the mouse model is AD finding is by normalizing membrane cholesterol content and reducing the appearance of abnormal cathepsin D - positive lysosomes, leading to reduced beta - secretase cleavage of APP and an upregulation of genes involved in cholesterol trafficking and Aβ clearance.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.