Sentences with phrase «model mice»

In addition, we have identified signaling pathways that are activated as part of the integrated stress response in response to soluble amyloid - beta and in AD model mice.

However, other AS model mice were significantly less likely to show this behavior, revealing a diminished ability to recall a previous incident.

What we'd like to understand is whether HD model mice have symptoms that resemble human depression.

Any scientist would also be quick to point out that even the best model mouse does not actually have autism, which is a uniquely human condition.

Both the patients and AD model mice were significantly impaired in terms of the distance traveled and the time it took for them to locate the hidden object.

However, other AS model mice had no memory of the platform location.

We previously reported that neuroinflammation contributes to the amnesia of AβPPswe / PSEN1dE9 Alzheimer's disease model mice fed a high - fat diet to induce type - 2 diabetes (T2DM - AD mice), but the underlying mechanism for the memory decline remained unclear.

Our studies in Rett model mice add to similar studies in mouse models of Down syndrome, neurofibromatosis, tuberous sclerosis and fragile X, which provide rational bases for their treatment in adulthood, providing hope for millions of affected individuals and their families.»

On this week's show: Kelly Servick talks about how the microbiomes of model mice can change the outcomes of experiments, and a daily news roundup

The researchers replicated these procedures on AD model mice lacking GCN2.

Later, he found that the inhibition of this signaling route also protected Alzheimer's - model mice from behavioral impairments and pathological phenomena typical to the disease.

The normal mice and the AS model mice with diminished expression of the Na / K - ATPase subunit searched the correct area of the maze in the same amount of time.

Francesco Longo is interested in understanding the synaptic and behavioral abnormalities associated with autism spectrum disorder, with particular attention to striatal dysfunction in fragile X syndrome model mice.

Abstract: We previously reported that neuroinflammation contributes to the amnesia of AβPPswe / PSEN1dE9 Alzheimer's disease model mice fed a high - fat diet to induce type - 2 diabetes (T2DM - AD mice), but the underlying mechanism for the memory decline remained unclear.

The study compared the performance of normal and Alzheimer's disease (AD) model mice on the Morris water maze with the performance of healthy control subjects and early - stage AD patients on a video game version of the task.

Moy's work focuses on the hormone oxytocin, which can be given as a drug to autism model mice and may encourage them to be more social.

Pozzo - Miller and his team found that Rett - like symptoms improved in model mice after treatment with LM22A - 4, and the distance the mice were able to travel in a test field was comparable with normal mice.

For their investigations, the team from the Children's Hospital of Philadelphia, Weill Cornell Medical College, Queen's University Belfast and the University of Pennsylvania used a frataxin knock - in / knockout model mouse model that has been available for a number of years, but had previously been overlooked for Friedreich's ataxia research as the neurological phenotype is modest and has a slow onset.

IP3R3, a MAM specific Ca2 + channel (an orange arrow, left), was mislocalized from the MAM in the ALS model mice (white arrow heads, right).

By contrast, the other AD model mice lagged significantly in performing these tasks.

Previous research has shown that AS model mice display brain dysfunctions that match neurological abnormalities observed in humans, including cognitive deficits such as long - term memory.

The availability of genetically engineered model mice that have the same genetic mutation found in human pancreas cancer patients (the KR as mutation) has made study of the possible causes more feasible, because changes in the mouse metabolism caused by obesity are similar to those in humans.

Excitingly, the in vitro expansion of MuSC cultures in the presence of PFI - 2 increased the yield and maintained the self - renewal capacity of MuSCs, and following transplantation into injured tibialis anterior muscles of muscular dystrophy model mice, boosted MuSC engraftment and overall therapeutic efficacy.

Genetic knockdown of HDAC4, or sub-chronic treatment with a novel selective Class IIa HDAC inhibitor, reverses elevated membrane excitability in striatal medium spiny neurons from R6 / 2 and zQ175 Huntington's disease model mice G. C. TOMBAUGH, S. GELMAN, A. BRADAIA, K. WADEL, V. GARDES, C. TOULLER, A. SERS, A. GHAVAMI, B. BUISSON, G. BATES, M. MIELCAREK, C. DOMINGUEZ, M. MAILLARD, V. BEAUMONT... Abstract / Posters

Analysis of fecal proteins revealed a reduced trypsin amount in the 5xFAD model mice as compared to the wild type.

Surprisingly, healthy glial cells made HD model mice less sick, suggesting these cells are more important that we previously thought.

Typically, MS - model mice experience severe motor problems, eventually leading to paralysis, but when they were given the drug the mice behaved perfectly normally.

For the last ten years our laboratory has been determining the molecular basis for dysregulated protein synthesis in fragile X syndrome (FXS) and how altered translation contributes to altered synaptic plasticity aberrant behavior in FXS model mice.

The lab was working on a method to increase BDNF levels in Mecp2 mice when they learned that another group had positive results when using LM22A - 4, a small - molecule mimetic of the loop domain BDNF and partial agonist of its receptor TrkB, in Rett model mice.

Here, the AD model mice lacking PERK were able to successfully maneuver through the mazes at rates achieved by normal mice.

Huntingtin aggregates (brown) are elevated in skin sections from HD model mice (left).

Here, the results were consistent with the maze findings — the normal mice and the AS model mice with diminished expression of the Na / K - ATPase subunit exhibited freezing behavior upon the return to the staging area where they'd earlier received the foot shock, demonstrating the ability to recall a previous incident.

Santini, E., Turner, K.L., Ramaraj, A.B., Klann, E. *, and Kaphzan, H. * (2015) Mitochondrial superoxide contributes to hippocampal synaptic dysfunction and memory deficits in Angelman syndrome model mice.

The results here were consistent with those of the AD model mice lacking PERK, demonstrating that removal of both kinases diminished memory deficits associated with Alzheimer's Disease.

The Systemic Amyloid Precursor Transthyretin (TTR) Behaves as a Neuronal Stress Protein Regulated by HSF1 in SH - SY5Y Human Neuroblastoma Cells and APP23 Alzheimer's Disease Model Mice.

In the Cell Reports study, the authors hypothesized that if they could decrease expression of this subunit, they could improve cognitive function of AS model mice.

Mochly - Rosen and colleagues identified several other potential biomarkers that were elevated in HD model mice, including the levels of 8 - hydroxy - deoxy - guanosine, a product of oxidative DNA damage, in the urine and the presence of mutant huntingtin aggregates and oxidative damage in muscle and skin cells.

Recently, Dr. Cohen's laboratory obtained an ethical approval to test the therapeutic efficiency of NT219 as a treatment in Alzheimer's - model mice, hoping to develop a future treatment for hitherto incurable neurodegenerative disorders.

For example, model mice, which were once modified by a laborious process that required multiple generations of breeding, can now be modified in just one generation.

He contacted Longo, outlining his group's plan to test LM22A - 4 in hippocampal function in Rett model mice.

The phosphorylation of eIF2alpha, which decreases protein synthesis, was previously found at elevated levels in both humans diagnosed with Alzheimer's and in Alzheimer's Disease (AD) model mice.

Here, they found both increased levels of phosphorylated eIF2alpha in the hippocampus of both AD patients and the AD model mice.

Moreover, this restoration also improved the model mice's synaptic function, diminished cognitive abnormalities, and normalized the structure of dendrites.

To explore this question, the researchers examined the neurological impact of two enzymes that phosphorylate eIF2alpha, kinases termed PERK and GCN2, in different populations of AD model mice — all of which expressed genetic mutations akin to those carried by humans with AD.

They examined behaviors of the following types of mice: normal mice, AS model mice, mice that had reduced levels of the Na / K - ATPase, and AS model mice in which expression of the subunit of Na / K - ATPase was reduced.

A previous study by Klann and his colleagues pointed to a potential cause for the condition — overexpression of a subunit of a protein termed Na / K - ATPase in AS model mice.

Delivery of rosuvastatin to ACH model mice (second from left) caused noticeable lengthening in bone compared to ACH model mice that received a vehicle (left).

It is hard to distinguish the ASD - model mice from normal mice at a glance, though the model mice look more anxious, said Takumi.

In recent years, researchers have found that both humans with Alzheimer's Disease and AD model mice have relatively high levels of eIF2alpha phosphorylation.

These were: AD model mice; AD model mice that lacked PERK; and AD model mice that lacked GCN2.