Sentences with phrase «model mice after»

Not exact matches

«The mouse is a particularly suitable model in which to study the development of the auditory system, because newborn mice are deaf and only begin to perceive acoustic signals at 12 days after birth.

Using a flexible mouse model, her team set out to determine whether anything could be done to restore memory «after a significant number of neurons are lost in the brain.»

The researchers confirmed these findings in a mammary carcinoma mouse model — treatment with dasatinib just a few days after administering two high doses of chemotherapy prevented tumor growth and increased survival rates.

Blocking this inflammation after radiation therapy brought a significant improvement in survival in a mouse model of the disease.

After further screening, three drugs, trifluoperazine, an antipsychotic, doxapram, a breathing stimulant, and amoxapine, an anti-depressant, were used in a mouse model and were found to be effective in treating plague.

In a mouse model of Alzheimer's pathology, the scientists observed that trained microglia amplified the formation of plaques even months after their immunological memory had been triggered, thus causing the disease to become more severe.

After chronicling the different shifts of decomposers on the mice, and seeing the same shifts operating on the humans, the researchers built a computer model using the mouse data to see whether the microbial composition could be used to predict times of death, using the humans as a test case.

To study the suitability of guanabenz as a therapeutic after MS symptoms have already appeared and peaked, the researchers used a mouse model in which symptoms relapse and remit — cycling from high severity to low severity to high again over time.

Mice given alcohol just after birth are a good model for measuring the impact on human fetal development because the brains of mice pups achieve developmental milestones after birth that are comparable to those in other mammals, including humMice given alcohol just after birth are a good model for measuring the impact on human fetal development because the brains of mice pups achieve developmental milestones after birth that are comparable to those in other mammals, including hummice pups achieve developmental milestones after birth that are comparable to those in other mammals, including humans.

In animal models, the modified T cells greatly reduced the tumor burden and prolonged overall survival: All mice that received the modified T cells were alive 44 days after treatment versus 29 percent and 17 percent of the study's two control groups.

These are skin sections from mouse psoriasis model, after treatment with solenopsin analog or control cream.

Using a model of Parkinson's disease in which the toxin MPTP, made famous in book «The Case of the Frozen Addicts,» induces Parkinson's - like symptoms in humans and mice, Dr. Smeyne showed that mice infected with H1N1, even long after the initial infection, had more severe Parkinson's symptoms than those who had not been infected with the flu.

The current study found that mice meant to serve as a model of ischemic human heart failure (weaker blood flow after a heart attack) had higher levels of activated, pro-inflammatory macrophages, monocytes, dendritic cells and T cells trafficking between their hearts and spleens than did control mice with healthy hearts.

Now, the Laboratory of Malaria Immunology Team at the Immunology Frontier Research Center (IFReC), Osaka University, headed by Professor Cevayir COBAN, have used mouse malaria models to show that robust immune activation and invasion of parasite by - products into the bone marrow during and after malaria infection leads to an adverse balance in bone homeostasis - a process usually tightly controlled - by bone forming osteoblasts and bone resorbing osteoclasts.

In a study in the American Journal of Physiology - Heart and Circulatory Physiology, Halade and colleagues looked at functional and structural changes of the three organs at four time points: one day and five days after heart attack, which is the acute heart failure period in the mouse model, and 28 days and 56 days after heart attack, which is the chronic heart failure period.

After confirming in mouse models that cells from HER2 - positive breast cancers became resistant to anti-HER2 treatment when implanted into the brain but not into other tissues, the investigators found that HER3 is overexpressed in brain metastases of HER2 - positive breast cancers from both mice and human patients.

She looked after her children during the first year and took a postdoc on mouse models of human fertility in a genetics group at the Stanford School of Medicine in their second year in California.

«Our results explain why post-exposure prophylaxis» — short - term treatment after exposure to HIV to reduce infection — «with antibodies is more effective than ART in our mouse models.»

In mouse models, miR - 29 not only blocked pulmonary fibrosis, it reversed fibrosis after several days.

The authors came to their conclusion after studying skin cells in mouse models using a confocal and two - photon microscopes, and developing mathematical models.

Tests on mouse models for type 1 diabetes show that one injection works for a minimum of 14 hours, during which time it can repeatedly and automatically lower blood sugar levels after mice are given amounts of sugar comparable to what they would consume at mealtime.

To determine whether treatment with Osteolectin could reverse bone loss after the onset of osteoporosis, the CRI research team used mice that had their ovaries removed to model the type of osteoporosis that develops in postmenopausal women.

The researchers compared their new mouse model with young mice that have immune system defects and are known to die several days after Zika infection.

After first verifying that stem cells injected to the brain would travel to multiple metastatic sites and not to tumor - free areas in their model, the team injected stem cells loaded with oHSV into the carotid artery of metastasis - bearing mice..

Several tests in cultured cells indicated that ganciclovir would cause the death of HSV - TK - expressing stem cells, and testing in the mouse model confirmed that administration of the drug after successful treatment of brain metastases successfully eliminated therapeutic stem cells that also expressed HSV - TK.

Development of a mouse model of lung chronic infection to study disease progression after NTMs infection and response to novel antibiotic therapies.

In mouse models of the disease, tau tangles didn't form after the plaques appeared.

The experimenters successfully tested the compound in the two mouse models «either treating right at the beginning of diabetes, or for reversal of toxic effects after three or four months of diabetes, which is even more difficult,» King says.

After colleagues at Sanofi provided an investigational compound that activates PKM2, the team showed that this compound could stop abnormalities in mouse podocytes both in cell culture and in two mouse models of diabetes.

«We could develop mouse models of these genetic polymorphisms, for example, to observe in detail the role they play after a fracture,» Reid said.

Even seven months after treatment, the mouse models still showed no signs of the disease, while untreated mice developed problems after two weeks.

This experiment was conducted to verify the findings in the initial experiment of a hypersensitivity immunopathologic - like reaction after SARS - CoV challenge of vaccinated animals, to determine if a higher dosage of the S protein vaccine (SV) would suppress infection and still exhibit a similar reaction, and whether the original β propiolactone inactivated whole virus vaccine (BPV) that had shown an immunopathologic - like reaction after challenge of vaccinated ferrets and nonhuman primates exhibited a similar immunopathologic reaction in the mouse model [13], [14].

Adenovirally generated induced pluripotent stem cells mediate a preservation of motor function or behavioral recovery after transplantation in a mouse model of Huntington's Disease

Meanwhile, Granier became interested in adiponectin receptors after a Japanese group showed that a small molecule could activate the receptors for to increase insulin sensitivity in an obese mouse model.

After creating a pathological mouse model deficient for this gene, through the Gencodys Consortium (Genetic and Epigenetic Networks in Cognitive Dysfunction; http://www.gencodys.eu/), scientists from PHENOMIN and the IGBMC showed major memory defects, as well as significant symptoms of hyperactivity on this model.

«There is an ALD mouse model but these mice have only minimal symptoms that occur after 18 months.

Findings (i)- (iii) strongly resemble the changes seen after Abeta immunotherapy in mouse models of AD and suggest that the immune response generated against the peptide elicited clearance of Abeta plaques in this patient.

It is known that motor abnormalities in CAG 94 KI and CAG 140 KI mouse models are present from an early age, with a delayed onset observed in the CAG 94 KI model as compared to CAG 140 KI; in addition, overt behavioral deficits were observed after 2 years of age in the CAG 140 KI mouse model (Menalled et al., 2003, Hickey et al., 2008).

The technique could prevent liver damage not only in models of chronic hepatitis, but also in an acute liver damage model, in which all mice normally die within 3 days.4 After knocking down Fas in the liver, most mice survived the lethal challenge and recovered.

Using a model where K - ras acts as an oncogene and initiates tumor formation, mice that were bred to not have Notch1 function showed an almost uniform distribution of about two cancerous lesions per mouse after 6 weeks, compared with approximately 14 tumors / mouse for those with Notch1 function still remaining.

Furthermore, we did not observe any change in ApoE content on TRLs after ApoC - III depletion in any of the mouse models (Supplemental Figure 8A).

A Dive Into the Research Some studies, including a small 2016 cohort trial and a 2014 mouse model, only found benefit after 48 to 72 hours of fasting.

Studies in mice models have shown that sirtuin activity is inhibited after consumption of a high - fat meal.

Zootopia unfolds as a mystery procedural, as Judy and Nick traverse the varied terrains of Zootopia to crash the place of a mouse gangster modeled after Don Corleone, drop in at a DMV hilariously run by sloths (whose slow speech and movements give the film by far its biggest laughs), and uncover corruption and conspiracy.

From a kitty playground to a napping pod modeled after a lunar spaceship (and equipped with built - in feeding bowls and astro - mice toys), they're intriguing for both cats and humans.

After college, Dr. Cesario worked in a lab at Cornell University developing mouse models of human prostate and mammary cancers, amongst others.

On top of all that, we throw in a box - full of exclusive items themed after the game of the month. Weâ $ ™ ve made moleskin notebooks, cloth banners, custom statues, figures, plushes, decks of cards, model airplanes, mouse pads, custom glassware, and yes, even socks, all themed and designed exclusively for IndieBox games.

Modelled after the official SNES mouse, the Hyper Click is compatible with the SNES system and can be used with any of the SNES Mouse - enabled timouse, the Hyper Click is compatible with the SNES system and can be used with any of the SNES Mouse - enabled tiMouse - enabled titles.