Sentences with phrase «model mice from»

Later, he found that the inhibition of this signaling route also protected Alzheimer's - model mice from behavioral impairments and pathological phenomena typical to the disease.

Not exact matches

Other rows are eyes from three different mouse models of diabetes.

In the new work, published June 10 in the journal Scientific Reports, Zhao, Reid and colleagues used a highly sensitive probe to measure electrical fields in the corneas of isolated eyes from three different lab mouse models with different types of diabetes: genetic, drug - induced and in mice fed a high - fat diet.

The researchers collected samples of indoor dust from 11 homes in North Carolina and tested extracts from the samples in a mouse pre-adipocyte cell model, 3T3 - L1 cells, often used to test compounds for potential effects on the accumulation of triglycerides, a type of fat.

Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study of molecules to treat cancers caused by human herpes virus infection in mice models of disease.

PDX models are created by implanting cancerous tissue from a human primary tumor directly into immunodeficient mouse or rat models, enabling acceleration of oncology research or drug discovery and development programs.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

Ellen Heber - Katz, a scientist at The Wistar Institute in Philadelphia, used to study autoimmunity — that was until she noticed something strange in the mice she was using to model lupus: The small holes that she had poked in their ears to distinguish the animals from one another kept closing.

Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition studies than pigs or mice and we could potentially use data from dogs to study the impact of diet on gut microbiota in humans, and humans could be a good model to study the nutrition of dogs.

«Our MICE model uses whale numbers dating back from 1890 to now and then couples this with food availability and ocean physics to understand the changes to ocean conditions that whales are likely to experience,» Dr Plaganyi said.

Data from in vivo mouse models indicate that delivery of the DMAb sequence for the influenza A-targeted monoclonal antibody protected against lethal doses of two very different, clinically relevant influenza A viruses.

Again, using mouse models of glioblastoma — this time created from brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.

Specifically, the Mount Sinai study was designed to test whether pharmacological compounds designed to block the function of XPO1 / CRM1 could stop disease progression in mouse models that exhibit some of the characteristics of MS. Researchers found that two chemical agents (called KPT - 276 and KPT - 350) prevented XPO1 / CRM1 from shuttling cargo out of the nucleus of nerve cells, which protected them from free radicals and structural damage.

Engineered human immune cells can vanquish a deadly pediatric brain tumor in a mouse model, a study from the Stanford University School of Medicine has demonstrated.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

In addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.

So much of what you learn depends on how you ask the questions; we are asking the questions a little differently from the academics who study mouse models.»

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

The most pivotal of those experiments involved the development of a novel «knock - in» mouse model in which a point mutation was introduced in GRK2 to prevent NO from binding (a process called nitrosylation).

Most importantly, these cells protected mice from developing diabetes in a model of disease, having the critical ability to produce insulin in response to changes in glucose levels.

So until recently, much of what scientists learned was gleaned by inference or from studying mouse models of the disease.

With collaborators from India, Japan, and the United States, the inStem lab is exploring «biochemistry, biophysics, humanized mouse models, and single - cell models.»

Additionally, work in a mouse model revealed similar cells, indicating that the progenitors are conserved from mouse to human, and therefore, they must be «important cells with promising potential for cell therapy in treating liver disease,» explained Dr. Gouon - Evans.

Unlike rodent models, which are developed from inbred strains of mice kept in controlled environments, companion animals, like humans, are genetically diverse and are exposed to many of the same environmental influences as their owners are.

Antibiotic treatment reduced motor deficits and molecular hallmarks of Parkinson's disease in a mouse model, whereas transplantation of gut microbes from patients with Parkinson's disease exacerbated symptoms in these mice.

Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.

The researchers who study these various mouse models acknowledge that they differ from humans in many critical ways.

She and her colleagues will be exploring the role of YY1 further, using clinical samples as well as mouse models, to look at the protein in diseases like lupus to deepen their understanding of how autoimmunity could result from the «escape» of immune genes from X chromosome inactivation.

In collaboration with the group of Valerian Kagan, Ph.D., D.Sc., at the University of Pittsburgh, Gabrilovich and colleagues analyzed in great detail the events that take place in the DCs from tumor - bearing mice models and found that impaired cross-presentation, which occurred in the presence of tumor - derived factors, was associated with defective trafficking of the antigen - MHC complex to the cell surface.

When the researchers looked for prostaglandins in COX - deficient mice models from Vanderbilt using mass spectroscopy tests, the signaling molecules were there — and not just in the ovaries.

In a mouse model of triple - negative breast cancer, mice injected with cancer cells that over-express ZMYND11 had tumor volumes of less than 50 cubic millimeters while control mice and those injected with cells expressing ZMYND11 deficient for binding to the methyl group had tumor volumes ranging from 150 to 400 cubic millimeters at eight weeks.

This anxious behavior mirrored that of CdLS patients, while autopsied brain tissue from individuals with CdLS showed symptoms of disease that matched those of the experimental mice suggesting that they were a good animal model.

Desgrosellier said the team will follow up with mouse models containing tumor fragments from patients to better reflect the diversity of cell types present in human disease.

«The next thing to do is to generate a knockout mouse model for further in vivo analysis, as the ultimate goal of our research is to move from bench to bedside, and generating a mouse model is a key step during this long journey,» Shi said.

Researchers from the Eaton - Peabody Laboratories of the Massachusetts Eye and Ear and Harvard Medical School have created a new mouse model in which by expressing a gene in the inner ear hair cells — the sensory cells that detect sound and sense balance — protects the mice from age - related hearing loss (ARHL) and noise - induced hearing loss (NIHL), the two most common forms of deafness.

The first key experiment involved removing a specific subset of activated T - cells from mouse models.

And the trouble with extrapolating so much from mouse studies is that «nobody has actually shown over the long term how long these quote un-quote improvements persist, and we don't know whether it's broadly improving aspects of aging or it's specific to certain tissues,» said Matt Kaeberlein, a biologist who studies aging in dogs and other animal models at the University of Washington.

Furthermore, without detectable side effects, the peptide protected mice from chemical - induced colitis that models irritable bowel syndrome.

«To our knowledge, our model is the first in which expression of a single gene in postnatal hair cells results in hair cell survival and hearing preservation in mice that otherwise suffer from age - related and noise - induced hearing loss,» Dr. Chen said.

The scientists, including Florian Reisinger from the Institute of Virology (HMGU) and Dr. Kristian Unger from the Research Unit Radiation Cytogenetics (HMGU) showed this using mouse models.

«Using a genetic mouse model of DIPG, we found that the histone mutation turns off p16, which is a gene that acts like a break on dividing cells,» says senior author Oren J. Becher, MD, from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago.

Dr. Baran Sumer (left) and Dr. Jinming Gao (right) and have invented a transistor - like threshold sensor that can illuminate cancer tissue, helping surgeons more accurately distinguish cancerous from normal tissue in mouse models.

Research in recent years has covered both preclinical basic research and the transfer of the results generated from studies of mouse models to clinically applicable techniques for treating female infertility.

Efforts aimed at finding better drug regimens would therefore greatly benefit from a mouse model with an intrinsic marker that can indicate different stages of pancreatic tumor formation leading to cancer and reflect the effects exerted by novel drug candidates.

From the first day of transplantation, the cells produced insulin in response to glucose spikes in the mice's blood, alleviating the modeled diabetes.

The team showed in mouse models that these two types of cells originate from a common precursor stem cell in the embryo.

They then selected six compounds to represent a wide range in the degree of bias (from those that preferred barrestin2 recruitment to those that almost exclusively preferred G protein signaling) and determined their overall potency for inducing analgesia and respiratory suppression in mouse models.

She has now investigated in the mouse model what information individual neurons in the visual cortex receive from other neurons about the wider visual field.

Apart from a few studies in mouse models and in cell lines, there is no laboratory evidence that synthetic phosphoethanolamine works as a cancer drug.

Application of sun protection factor 30 (SPF30) sunscreen prior to exposure to ultraviolet - B (UVB) light delayed melanoma onset in a mouse model of the disease, according to data from a team at The Ohio State University Comprehensive Cancer Center Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.