Sentences with phrase «model mice lacking»

Here, the AD model mice lacking PERK were able to successfully maneuver through the mazes at rates achieved by normal mice.

Not exact matches

Because companies have resources — reagents, proprietary mouse models, the ability to conduct toxicology studies, and so on — that even major research universities may lack, Giger says.

They validated the cell models and showed that changing clock gene function in these cells is similar to what happens in mice lacking clock genes.

In a mouse model in which they simulated the development of CML by adding Bcr - Abl to the bone marrow, a shortage of Gab2 led to a clear weakening or even a lack of symptoms.

Working with a mouse - model of parainfluenza virus infection, Sendai virus, which causes similar symptoms and patterns of tissue damage to RSV, researchers found that mice fared much worse in fighting the infection when their cells lacked IL - 27 signaling.

Studying aging and its associated diseases has been challenging because existing vertebrate models (e.g., mice) are relatively long lived, while short - lived invertebrate species (e.g., yeast and worms) lack key features present in humans.

Although genetically modified mice have been used widely to model neurodegenerative diseases, they lack the typical neurodegeneration or overt neuronal loss seen in human brains, says corresponding author Xiao - Jiang Li, MD, PhD, distinguished professor of human genetics at Emory University School of Medicine.

To explore that question, Mazmanian and colleagues at Caltech used a mouse model of autism that is thought to approximately recreate three of the disorder's hallmark deficits: lack of social interaction, decreased communication (mice normally emit ultrasonic, birdsonglike chirps), and repetitive behaviors such as compulsive grooming or burying marbles.

Therefore, his team, led by postdoctoral fellow Gayatri Arun, set out to discover what would happen if mice that model human metastatic breast cancer were bred with the mice lacking Malat1.

When they subjected mice that lacked the interferon gamma gene to the severe asthma model, they found that the mice could not be induced to develop severe asthma.

To test this hypothesis, the researchers crossed J20 transgenic mice (a common mouse model of Alzheimer's) with caspase - 2 null mice (mice that lack caspase - 2).

Frustrated by the lack of a good study model, Krasnow and his colleagues turned to the mouse lemur and began conducting detailed physiologic and genetic studies on hundreds of these petite, docile creatures in the rainforests of Madagascar.

These were: AD model mice; AD model mice that lacked PERK; and AD model mice that lacked GCN2.

«This regulatory mechanism is critical in vivo, where we find that mice lacking HOIL - 1L are completely resistant to sepsis, which is a lethal inflammation model of human sepsis,» said Mary Rodgers, PhD, USC postdoctoral fellow and the study's first author.

Mice expressing p53Δ31, a mutant p53 lacking the C terminus, model dyskeratosis congenita.

While earlier work has reported persistence of HIV in these cells — macrophages — investigators in this work developed a mouse model with an immune system generated from human cells but lacking T cells, which are a primary target of and reservoir for HIV.

The lack of 5D12 binding in synaptic zones may limit its therapeutic effect, as appeared to be the case in LBD - model mice (vide infra).

Because of the lack of a small animal model for HIV transmission at the time, we decided to first try to block herpes transmission in mice.

The research team, led by Emory Vaccine Center immunologist Bali Pulendran, discovered that mice lacking the amino acid sensor GCN2 are more sensitive to the chemical irritant DSS (dextran sodium sulfate), often used to model colitis in animals.

To study the influence of monoamine oxidases (MAOs) during mammalian development, researchers from the laboratory of Boyang Jason Wu (Washington State University, USA) investigated a mouse model lacking both MAO isoforms (A and B).

For example, transgenic mice lacking dopamine, a key brain chemical for motor control, provide an integral animal model for studying the changes in brain dynamics during the induction and recovery from an induced Parkinsonian state.

In addition, Dr Bateman's team will test whether compensating for the lack of Unkempt activity can prevent the neurological problems that develop in a mouse model of TSC.

In the mouse model of type 1 diabetes, susceptibility was also associated with variation in CTLA - 4 gene splicing with reduced production of a splice form encoding a molecule lacking the CD80 / CD86 ligand - binding domain.

Not only do both models of the Aspire S7 have the SD card reader that the XPS 12 lacks, but the 13.3 - inch S7 comes bundled with Micro HDMI to VGA and USB to Ethernet adapters, not to mention a cheap Bluetooth mouse and a microfiber - lined sleeve.