Sentences with phrase «model mice less»

Surprisingly, healthy glial cells made HD model mice less sick, suggesting these cells are more important that we previously thought.

Not exact matches

The less - complex nervous system of the fruit fly makes them easier to study than people or even mice, another genetic model organism.

The obvious key to living longer is to eat less, and significantly cutting calories has been shown to lengthen life span substantially in model organisms such as worms and mice.

Scientists previously had to rely on less accurate mouse models.

Intriguingly, in the new study, the brains of mice modeling autism that were fed the high - glycemic index diet had drastically less doublecortin, a protein indicator of newly developing neurons, compared to predisposed mice on the low - glycemic index diet.

In a mouse model of triple - negative breast cancer, mice injected with cancer cells that over-express ZMYND11 had tumor volumes of less than 50 cubic millimeters while control mice and those injected with cells expressing ZMYND11 deficient for binding to the methyl group had tumor volumes ranging from 150 to 400 cubic millimeters at eight weeks.

In a mouse model of eczema, loss of the HTR7 gene in mice led to significantly less scratching and less severe skin lesions.

When SphK1 was inhibited in a mouse model of sickle cell disease, red blood cells lived longer and had less sickling.

«The cells are bigger and fire less than control cells — exactly what we see in the mouse model.»

«Targeted chemotherapy shows early signs of slowing tumor growth with less toxicity: Mouse model research shows promising method of helping childhood cancer survivors avoid late effects of chemotherapy.»

Multiple mouse models of SMA have been produced, generally by knocking out the endogenous mouse SMN1 gene and replacing it with one or more copies of the human SMN2 gene that produces much less full - length SMN protein than the SMN1 gene.

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

Additionally, when tested in a second mouse model, some of the UPEC strains that successfully infected the first caused a less severe outcome.

Mouse models of rectal cancer will also allow the researchers to understand whether certain therapies or combinations of therapies can make a tumor more or less likely to respond.

Using a mouse model of atherosclerosis, Ley inoculated animals with the vaccine and observed approximately 50 % less plaque in their arteries compared to arteries from unvaccinated mice.

In contrast to rats and hamsters, the mouse is used less frequently as a model for sucrose / fructose - induced IR and hyper - TG as the commonly used C57BL / 6 mouse either does not develop IR or develops the phenotype more slowly (9, 14).

In January 2016, no less than three studies published in the journal Science and contributed by collaborative teams led by researchers at Harvard University and the Massachusetts Institute of Technology (Tabebordbar M et al. 2016), the University of Texas Southwestern Medical Center (Long C et al. 2016) and Duke University (Nelson, CE et al. 2016) reported using CRISPR (clustered regularly interspaced short palindromic repeats) / Cas9 (CRISPR - associated protein 9) genome editing approaches to permanently correct the genetic mutation in the well - known Dmdmdx mouse model for DMD (C57BL / 10ScSn - Dmdmdx / J — 001801).

In other words it becomes less clear what that spectra means if it can be induced by fresh air as well, its hard to inderstand why the control group gets dropped for the second part of the analysis, remember the majority of the study is in generating the mouse model data, and half that is the control group, its strange to sudden forget to include it in half the analysis.

There is one caveat to that statement, however: per USB design specifications, USB - based keyboards and mice should draw less than 100mAh of power but many models disregard that specification and draw more.