Sentences with phrase «model mice on»

Not exact matches

I'd start smelling something odd when running the air circulator, pull the cabin air filter, and find a mouse nest on top.The solution was a bit different for this model year.

Using a «gnotobiotic mouse model» — where mice were «colonized with a synthetic human gut microbiota composed of fully sequenced commensal bacteria» — Desai et al reported on the effects of different diets with different fibre content.

Because companies have resources — reagents, proprietary mouse models, the ability to conduct toxicology studies, and so on — that even major research universities may lack, Giger says.

The researchers collected samples of indoor dust from 11 homes in North Carolina and tested extracts from the samples in a mouse pre-adipocyte cell model, 3T3 - L1 cells, often used to test compounds for potential effects on the accumulation of triglycerides, a type of fat.

Using the mouse as an experimental model, LMU neurobiologist PD Dr. Conny Kopp - Scheinpflug and her research group have now demonstrated that the activity of nerve cells in the auditory system has a direct effect on myelinization — higher levels of activity correlate with the formation of thicker myelin sheaths.

To study this question, the researchers focused on the grey mouse lemur, a small primate whose lifespan (around twelves years) makes it a very good model for the study of aging.

In the study, researchers worked with a mouse model that has a debilitating mutation on one of the exons of the dystrophin gene.

The positive effect of sialic acid Neu5Gc on the respiratory system was confirmed using a mouse - model: The Neu5Gc molecules consumed with food improved the pulmonary function of the mice, therefore reducing asthma symptoms.

Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition studies than pigs or mice and we could potentially use data from dogs to study the impact of diet on gut microbiota in humans, and humans could be a good model to study the nutrition of dogs.

The scientists are testing the ability of drugs already on the market to reverse this cellular transformation in the pancreas in mice models of human pancreatic cancer.

In the current study, Frank Longo, MD, PhD, and others at Stanford University, tested LM22A - 4, a drug that specifically binds to and activates the BDNF receptor TrkB on nerve cells, in mice that model the disorder.

So much of what you learn depends on how you ask the questions; we are asking the questions a little differently from the academics who study mouse models.»

Working with mouse models of cancer, they demonstrated how treatment with antibiotics on top of chemotherapy may be significantly superior to treatment with chemotherapy alone.

In this study, the researchers performed a series of electrophysiological and behavioral experiments on a mouse model of schizophrenia developed at CUMC.

The latest findings build on previous work by Dr. Habib's lab showing that the same combination of drugs was successful in a mouse model of glioblastoma, a deadly type of brain cancer.

then tested its effectiveness on human pancreatic cells that had been implanted in mouse models.

Last fall, Bergö's group reported that ingestion of extra antioxidants drove the metastasis of melanoma in a mouse model, though they didn't have any effect on the primary tumor.

«The effects of young blood on cognition have not been replicated by an independent group, and there has never been a test with a mouse model of Alzheimer's.»

«For example, cancer research is heavily reliant on mouse models, and as a result we've become very good at curing mice, but that hasn't translated very well to humans.

Two years into her research on a mouse - model study of a gene pathway's role in the immune system, she joined UCB Celltech.

This take on Michelangelo's famous Sistine Chapel image symbolizes the link between human pain patients and the mouse model: The lab - designed SPR inhibitor (in green), shown within the active pocket of SPR itself (in gray with its atomic structure in colored lines), is the «bridge» between the two species.

Scientists previously had to rely on less accurate mouse models.

Intriguingly, in the new study, the brains of mice modeling autism that were fed the high - glycemic index diet had drastically less doublecortin, a protein indicator of newly developing neurons, compared to predisposed mice on the low - glycemic index diet.

Using a model of minimal TBI in mice, the team evaluated the effect of transition to an enriched environment on behavioral and cognitive parameters.

Lastly, they plan to vary the timing of exposure to the various diets in the mouse model of autism, by, for example, giving pregnant mice a high - glycemic index diet and then keeping their pups on a normal diet.

Now, the researchers have discovered an alternative in a mouse model: in the case of breast tumours with a specific defect in DNA repair, the animals can be cured using already established, cheap chemotherapy drugs, if enough DNA damage can be inflicted on the resting tumour cells.

The mouse models of autism on a normal lab diet (with a medium glycemic index) are already known to generate fewer new neurons, and some of their existing cells and neuronal connections are abnormal compared with those of normal mice.

The research of different types of cancer and the testing of new treatments depends on accurate mouse models.

Witt - Enderby at Duquesne is using her expertise in molecular pharmacology to study the effects of melatonin on a mouse breast cancer model.

Realizing they might have a potentially effective drug on their hands, Bogyo and his colleagues brought in Sonnenburg, whose lab is adept at using mouse models of C. difficile infection.

The sequencing of the first genome involving a cockroach species may one day serve as a model system comparable to how research on mice can apply to humans.

«Using a genetic mouse model of DIPG, we found that the histone mutation turns off p16, which is a gene that acts like a break on dividing cells,» says senior author Oren J. Becher, MD, from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago.

This visual abstract shows how using a mouse model of restraint stress, Wu et al. uncovered the intergenerational effects of paternal psychological stress on glucose metabolism in offspring.

With chronically infected mice as their model, the researchers used a new technology called ATAC - seq to map the regulatory regions of the genome — the sections of DNA involved in switching genes on and off — in the animals» exhausted and functional CD8 + T cells.

I work in hearing research, and I am now working on genes that are linked to blood (platelet) disorders as well as with mouse models expressing mutant steroid (androgen) receptor genes.

A lot of the work that we do relies on the use of rodents, animal models, rats and mice in particular.

In mouse models of disease, Yale researchers looked at the effects of providing nutrients during infection and found opposing effects depending on whether the infections were bacterial or viral.

Insects are an important model for the study of emotion; although mice are closer to humans on the evolutionary family tree, the fruit fly has a much simpler neurological system that is easier to study.

Moy's work focuses on the hormone oxytocin, which can be given as a drug to autism model mice and may encourage them to be more social.

Treating the potentially blinding haze of a scar on the cornea might be as straightforward as growing stem cells from a tiny biopsy of the patient's undamaged eye and then placing them on the injury site, according to mouse model experiments conducted by researchers at the University of Pittsburgh School of Medicine.

After chronicling the different shifts of decomposers on the mice, and seeing the same shifts operating on the humans, the researchers built a computer model using the mouse data to see whether the microbial composition could be used to predict times of death, using the humans as a test case.

Because of these limitations, most pancreatic cancer research relies on genetically engineered mouse models of the disease, which can take up to one year to generate.

Durante said the next step will be a pre-clinical trial to test glutamine's effect on a mouse model of coronary artery disease.

In a four - year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kill.

Mice given alcohol just after birth are a good model for measuring the impact on human fetal development because the brains of mice pups achieve developmental milestones after birth that are comparable to those in other mammals, including humMice given alcohol just after birth are a good model for measuring the impact on human fetal development because the brains of mice pups achieve developmental milestones after birth that are comparable to those in other mammals, including hummice pups achieve developmental milestones after birth that are comparable to those in other mammals, including humans.

They show that this new formulation reduces the minimal curative dose in a disease model, based on infections in mice, by 100-fold and, most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.

Mice have proven to be a particularly good model for studies relevant to humans, Magnusson said, on such topics as aging, spatial memory, obesity and other issues.

The group also tested low - dose topical application of growth factors on diabetic mice, which are a common model for impaired wound healing.

To build on the work, Anguera's team is performing additional studies using primary samples from lupus patients as well as samples from a mouse model of lupus.

Fink and Tiwari, both of Case Western Reserve, completed the work on the colitis mouse model.