Sentences with phrase «model of a human disease»
«Future studies need to determine the health effects of these cocoas in models of human disease and to evaluate the consumer acceptability of the cocoas as part of a chocolate product.»
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From accelerating the identification and validation of novel therapeutic targets, to creating better animal models of human diseases in a shorter time frame, to reducing the number of failed products, Crispr looks set to shave millions off R&D costs and boost drug discovery, she says.
Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.
«It has the potential to inform clinical practice and also guides us about the relevance of animal models of human disease and how we can reduce and refine their use.»
She analyzes the comparative histopathology of genetically altered mice and models of human diseases, including cancer, inflammatory disorders, and microbial infections.
«Large animal models of human disease, like cats, are really helpful for determining what's going to happen in a child when you're treating them,» Vite said.
The new Mount Sinai study reveals how loss of a protein called Sirtuin1 (SIRT1) affects the ability of blood stem cells to regenerate normally, at least in mouse models of human disease.
The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease.
She notes that biomedical researchers use macaques in part because they can offer good models of human disease.
«New MRI approach detects early liver tumors in mouse model of human disease.»
Thomas W Geisber, an expert on Ebola and siRNAs at The University of Texas Medical Branch, said the research was «highly significant because it shows protection against Ebola in a robust model of human disease: non-human primates.»
No, studies using animal models of human disease as well as «humanized mice» are expressly forbidden.
«We can harness the power of zebrafish genetics to create genetic models of human diseases.»
Facilitate communication between curators that have an interest in annotating animal models of human disease
During its Preparatory Phase, INFRAFRONTIER aimed at resolving the major issues required for implementing a sustainable INFRAFRONTIER Research Infrastructure for systemic phenotyping, archiving and distribution of mouse models of human diseases:
OMC is a scientific and technological platform aimed at supporting R&D activities related to the validation and use of mouse models of human disease.
Capacity building to meet the increasing demand of the biomedical research community for systemic phenotyping, archiving and distribution of mouse models of human diseases.
Click to view article: Mouse model of human disease still good, but significant differences exist
Each month through partnerships with researchers around the world, the MMRRC enhances critical research with a continuously expanding catalog of mouse models of human disease.
The phenotyping department of PHENOMIN - ICS is advancing a technical platform for functional characterization of preclinical models of human diseases with respect to both genetic understanding of pathophysiological mechanisms and the assessment of drug therapies.
These changes may influence the cells» abilities to serve as models of human disease and development.
It creates customisable and high - scale mouse models of human disease or displaying an abnormality (KI, KO mouse models) and it provides a complete phenotyping characterisation of the immune system by polychromatic and mass cytometry measuring more than 50 simultaneous quantitative parameters in standardised conditions.
Gladstone scientists are engineering tissues from stem cells to create better models of human disease.
Reconstruction of transgenic and gene knockout and knockin mouse models of human diseases.
Technical approaches of mouse model of human diseases.
His research focuses on understanding the role of genetic variation in contributing to human health and disease using mouse models of human disease, and more recently exploiting technologies developed for biomedical research for application in the field of genetic pest management.
Researchers have managed to insert that gene into mice to make a living, breathing model of a human disease that mice would otherwise never acquire.
I am currently working on a variety of NIH - funded projects, including areas such as bioinformatics research portals, visualization for review of chart records, and tools for aiding the discovery of animal models of human diseases.
The technology also has the potential to knock out specific genes to create pig models of human diseases.
More than 200 investigators from more than 100 institutions in 17 countries have come to the MMPC to learn strategies for studying mouse models of human disease.
Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential to provide improved cellular models of human disease.
I am particularly pleased that the fundamental knowledge of gene function and the derivation of animal models of human disease are underpinning important therapeutic advances.
The Jackson Laboratory Research scientist / Animal models of human disease, Mouse Mutant Resource, Genetic Resource Science 2006 - present
Dr. Dodds has been a member of many national and international committees on hematology, animal models of human disease, veterinary medicine and laboratory animal research.
Dr. Dodds has been a member of many committees on hematology, animal models of human disease and veterinary medicine.
Not exact matches
The Dr Hadwen Trust for Humane Research claims that «in some instances, reliance on inaccurate animal «models» of human disease have undoubtedly delayed medical progress.»
And researchers have developed a wide range of sophisticated computer models that simulate human biology and the progression of developing diseases.
Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a mouse model of the disease — potentially laying the groundwork for a new approach to treating severe cases of human depression in which drugs are ineffective.
They hope to create a human model that could help speed up the development of new drugs and vaccines against the disease, which sickens millions of people and kills thousands each year.
These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.
Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study of molecules to treat cancers caused by human herpes virus infection in mice models of disease.
The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.
The study of these highly unusual but devastating prion diseases has to date been thwarted by a lack of animal models that faithfully mimic the disease processes in humans.
By directly manipulating a portion of the prion protein - coding gene, Whitehead Institute researchers have created mouse models of two neurodegenerative diseases that are fatal in humans.
Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models.
Reductions in biodiversity from illegal wildlife trade can have other substantial negative human health impacts, including the loss of potential sources of pharmaceuticals, experimental models for studying disease, crop pollination and micronutrients for humans lacking alternative sources of protein.
Zebrafish are commonly used to model human diseases, in part because their larvae are transparent, making it easy to see the effects of genetic mutations or drugs.
With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»
«New models advance the study of deadly human prion diseases.»
We demonstrated that DENV serotype 2 (DENV2)-- specific human monoclonal antibody (HMAb) 2D22 is therapeutic in a mouse model of antibody - enhanced severe dengue disease.