Collaborating with Dr. Kevin Osteen on an in vivo mouse
model of adhesion formation.
Not exact matches
They developed a computer
model that better simulates how the cells recruit new ligands that eventually form focal
adhesions by altering the geometry
of the matrix's component fibers.
Given our
model results, we speculate a relationship between
adhesion and the variance
of cell lineage cluster size, which could determine the ability
of microbes to cope with variability in nutrient patchiness [62 — 65].
Current projects are investigating: 1) the expression
of inflammatory genes during ischemia and reperfusion
of kidneys during urology transplantation and in mouse
models; 2) the expression
of inflammatory genes and proteins in urine as markers indicating the presence
of rejection in renal allografts; and 3) the role
of adhesion molecules and chemokines in directing leukocyte infiltration into organ allografts.
In vivo imaging
of endothelial cell
adhesion molecule expression after radiosurgery in an animal
model of arteriovenous malformation.
Eph receptor and ephrin ligand signalling has been implicated in vascular development and in in vivo
models of angiogenesis where bi-directional signalling mediates juxtracrine cell — cell contact, cell
adhesion to extracellular matrix and cell migration30, 31,32.
They will then examine other mouse
models with mutations involved in cell -
adhesion and extracellular matrix molecules for signs
of RPE diseases.
Dr. Peden has written or contributed to more than 160 peer - reviewed scientific publications on the kinetics and mechanisms
of automobile exhaust catalysis; the development
of zeolite catalysts for diesel engine emission control; hydrocarbon reforming over bimetallic catalysts; the structure
of hydroprocessing catalysts; the development
of novel, supported solid acid catalysts for petroleum refining; the growth and properties
of oxide and semiconductor thin films; and
model studies
of adhesion at metal / metal - oxide interfaces.
The laboratory currently pursues four integrated research objectives: 1) Defining how dynamic regulation
of adhesion and migration controls metastasis, 2) Identification and characterization
of the metastatic cell populations within a primary tumor, 3) Experimental
modeling of metastasis in a clinically relevant manner, and 4) clinical implementation
of molecular markers
of migration as biomarkers
of tumor progression and metastasis.
That we observe cell sorting in EB culture also provides direct evidence, albeit in vitro, for the differential
adhesion model proposed for the resolution
of early PrEn and PrEc in the mammalian blastocyst in this same paper [56].
This principle
of variable torque displacement between the front and rear axles improves the traction, directional stability and road
adhesion of the 4MATIC
models.
Partly to compensate for rust problems on the 1957
models and partly to ensure that their Unibody cars would remain safe, as rust was a larger problem when body panels were required for strength, Chrysler pioneered the use
of electrostatic charges to improve anti-rust agent
adhesion in their 1960
models.