Sentences with phrase «model of copy number»

«Our preliminary data in cancers such as prostate, colon, liver and lung suggest a punctuated model of copy number evolution is also likely to be operative in other solid cancers,» said Navin.

Not exact matches

This murine model system offers a superior source of immortalized cell populations as many of the difficulties associated with the in vitro transfection process are eliminated (e.g., initial requirement for many cells, different sites of gene integration, multiple copy number; Ref.

From the measurements we infer copy - per - cell numbers for the transcripts, and we develop mathematical models to describe the kinetics of regulation.

The karyotype of Drosophila comprises only four copies of chromosomes, rendering it a very amenable model to study chromosome number defects.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

In the last year though a few competitors have popped up (see yesnomayb, a copy of the business model) and a number of free dating sites also started to eat away at traffic.

[11] The styling cues of the rear light clusters on the first - generation models were copied by a number of after - market accessory manufacturers for applications on other vehicles.

Incredible original condition Just in from Southern California Rare European model — sold new in Sweden 47,940 actual miles (77,152 KM) Matching numbers original engine Beautiful, factory correct paintwork Wonderfully original interior Over $ 27,000 spent on recent service work completed by a marque specialist that included complete brake, cooling, exhaust, fuel injection system rebuilds and more Documentation includes factory books, radio books, service records, $ 27,000 in recent service receipts, copy of build data card, factory tools and more Options include: New whitewall tires Becker Europa radio Rare 4 - speed manual transmission Drives and performs incredibly well!

Before the arrival of the «agency pricing» model that Apple negotiated with ebook publishers — which allowed the publishers to decide what price Apple would charge for their books on the iPad — Amazon had deals that paid a specific wholesale price to publishers for a certain number of copies, and then it was able to charge whatever it wanted for the books in the Kindle store.

BookBaby operates on an updated version of an outdated model, namely, having authors pre-order and purchase up front a specific number of copies of their print editions, much like vanity presses.

Bowles said the library would prefer a «hybrid model» with lower prices and no restrictions for a certain number of copies, adding that she understands the organization does need to «pay a premium.

Whilst the dominant model internationally is based on the idea of licensing «copies» of e-books, in Sweden the library treats e-books as a «service» with titles available concurrently to any number of patrons, for free.

Copy of a printed or online advertisement that shows the product with the same manufacturer and model number, the lower price, the date, and the retailer's name or website.

Make, model, year, car purchase papers, car loan papers, VIN number which can be located near the driver's side of the windshield, estimated mileage per year, driving license details, age proof, address proof, bank statements, copy of last 3 months salary slips, Social security number.

They should copy Apple, simplify the number of models and put more emphasis on the differences: low - cost laptop, medium - cost great light web surfing machine, high end powerhouse light or heavy... Last time I looked at a price list from Lenovo, they had about 400 models... Choice is great, except when it is illogical combinations.