Sentences with phrase «model of disease»
This was observed in human ovarian cancer cells grown in culture, and then in mouse models of the disease.
sciencedaily.com
The new study shows that a protein infused into the bloodstream, can improve the healing properties of stem cell therapy in animal models of the disease.
This stem cell model of the disease gave the scientists the unprecedented ability to study rapidly aging cells in the laboratory.
We aim to develop a system that links gene discovery to signaling pathways and eventually to set up animal models of disease by manipulating genes of interest through mouse genetics.
The conclusions, obtained by tracking thousands of mobile phone users, could help researchers devise more accurate models of disease outbreaks.
Most of those findings came from studies in cell line models of diseases, however.
The drug has shown positive results in recent studies of mouse models of these diseases.
We do not cover developments of interest only to specialists, such as new animal models of a disease or the opening of new science research centres.
Infectious disease epidemiologist specializing in the intersection between mathematical models of disease transmission and observational methods.
Poster: The utility of land cover maps to inform spatial epidemic models of disease transmission in the UK livestock industry.
«CRISPR - based technologies have begun to revolutionize many aspects of cancer research, including building mouse models of the disease with greater speed and greater precision.
After creating a stem cell model of the disease from patients» skin cells, the Scripps Research scientists found strong evidence for the involvement of a DNA repair enzyme in the FXN triplet repeat expansion.
Although stem cell therapy is fairly new to veterinary medicine, it has been demonstrated to be an effective treatment in numerous animal models of disease such as osteoarthritis, tendon repair, fractures, muscular dystrophy, autoimmune problems, and other disorders.
It's most similar to the common polygenic model of disease for T2D, suggesting that this study supports a minor role for rare and low - frequency variants.
«The ongoing line of work with this drug is an excellent example of the bench getting even closer to the bedside — our lab work with the drug in patient - derived xenograft models of disease makes possible the clinical trials taking place at the University of Colorado Hospital next door,» Jimeno says.
Caribou is pursuing near - term opportunities to develop the platform to engineer improved models of disease and for improved biomaterial production.
By adapting CRISPR / Cas9 technology, researchers of PHENOMIN and the IGBMC have been able to quickly and efficiently generate mouse models of diseases related to variations in the number of copies of certain regions of the genome.
The CRISPR - Cas technology is used to generate more accurate genotypic models of disease through precise genomic changes.
His uses genome engineering methods to test the role of specific genetic changes in induced pluripotent cell (iPSC)- derived models of disease.
The kidney structures also have the potential to facilitate further studies of how abnormalities occur as the human kidney develops in the uterus and to establish models of disease where they can be used to test new therapies.
For this study, Jabri and colleagues combined insights and data from celiac disease patients who had been cared for at the University of Chicago's Celiac Disease Center with experiments using a mouse model of the disease developed in her lab.
Mice bred to carry a gene variant found in a third of ALS patients have a faster disease progression and die sooner than mice with the standard genetic model of the disease, according to Penn State College of Medicine researchers.
«Feelings circulate in patterns analogous to what's seen from epidemiological models of disease,» reported Wired.
The NIH Roadmap Project should help by allowing them to compare models of disease with reference samples.
Computer models of disease, custom - designed pharmaceuticals for autoimmune conditions like arthritis and diabetes, new ways to deliver medications, new tests, cures for cancer — «these kids can do it all,» says Dean Immerman.
This human - agent model of disease dynamics can then be used to provide reproducible empirical analyses, yielding greater insights into the behavioural reactions and individual responses of people threatened by outbreaks of disease.
An award - winning cancer investigator and defender of the welfare of newborn children, Perera comes from the public - health model of disease, which assumes that most ailments are conveyed from outside the body and can be prevented.
Metabolites derived from the microbiome block protein misfolding in test tubes and prevent neurodegeneration in a fly model of a disease related to Parkinson's, hinting that gut - derived metabolites may hold therapeutic promise (Lap Ho, abstract 573.23, see attached summary).
In other words, there's no simple transmission model of diseases like Ebola and plague.
Strong evidence from a mouse model of the disease further confirms these mutations as a cause of aortic disease, and, together, the results point toward possible strategies for managing this inherited form of TAAD.
«The current model of disease is that when Mtb bacteria are inhaled, they reach the end of the lung — the alveolus — and then are ingested by a macrophage, a type of white blood cell that swallows and kills invading bacteria,» Dr. Shiloh said.
«In the future, such detailed digital models of diseases and the structure of organs could be used to help diagnose conditions, understand the impact of surgical interventions and even run digital drug trials.
Once this work is completed, a second stage is committed, in which researchers of I - Stem, in collaboration with specialists in animal models of diseases targeted by the therapeutic explore the effects of experimental transplantation of cells obtained laboratory.
Researchers are using CRISPR - Cas technology to generate more accurate and efficient models of disease in cell lines, primary cells, and animal models through gene knockout, DNA sequence insertion, or gene up - or down - regulation.
«It does a great job of tying up the molecular activation of HDAC inhibitors, and shows not only an in vitro effect, but a functional effect in an excellent model of the disease.»
Lynch is an expert in sphingolipid chemical biology and tests the effect of the inhibitors in mice and rat models of disease.
Building on Dr. Yamanaka's discoveries, Gladstone investigators who specialize in ALS have developed the first iPS - based, human neuron model of the disease, which they are now using both to evaluate potential pharmaceutical compounds to treat it, and to better understand how the disease progresses on a molecular level.
In 1998, Greg Cox identified the first mouse model of this disease called nmd2J which is still the only model of SMARD utilized for research.
Researchers previously made a chip model of diseased heart cells in order to study new treatments, and in a similar vein, last year a team at the Wyss Institute at Harvard modeled lung airways exhibiting COPD and asthma.
One potential reason for this discrepancy is that the laboratory tests used in animal models of the disease do not resemble the clinical assessments given to patients, and thus are not predictive of human memory performance.
«Dr. Cassera is one of a select few scientists who can work productively at the level of parasite biochemistry, biology, drug discovery, transmission, and even primate models of the disease.
Researchers at Penn State College of Medicine, working with Chinese and American colleagues, have discovered a novel way to enhance and restore cancer suppressor activity in B - cell acute lymphoblastic leukemia, resulting in better outcomes in a pre-clinical model of the disease.