Sentences with phrase «model of diseases like»

Not exact matches

Satellite imagery is used for all sorts of climate study, from identifying conditions that allow infectious diseases like West Nile virus and cholera to emerge, to creating models for predicting hurricanes, to distinguishing natural resources such as wind, water and sunlight.

A drug that acts like a growth - promoting protein in the brain reduces degeneration and motor deficits associated with Huntington's disease in two mouse models of the disorder, according to a study appearing November 27 in the Journal of Neuroscience.

«Computational models like this one might one day be able to predict the clinical course of a disease or injury, as well as make it possible to do less expensive testing of experimental drugs and interventions to see whether they are worth pursuing with human trials,» he said.

Another problem is that modeling studies, like this one, are inherently less powerful than other kinds of medical research: randomized clinical trials, the gold standard in medical research, in which patients are randomly assigned different treatments or no treatment; case - control studies, which compare patients who have a condition with those who do not; or cohort studies, which determine the risk of contracting a disease by studying a group of people with similar demographics.

The researchers developed a model of Alzheimer's disease and were surprised to find that increased levels of a gene involved in the production of toxic proteins in the brain not only led to Alzheimer's - like symptoms, but also to the development of diabetic complications.

She and her colleagues will be exploring the role of YY1 further, using clinical samples as well as mouse models, to look at the protein in diseases like lupus to deepen their understanding of how autoimmunity could result from the «escape» of immune genes from X chromosome inactivation.

Studies have shown that exercise can have both structural and cognitive benefits in rodent models of pathological conditions like Fetal Alcohol Spectrum Disorders (FASD) and Alzheimer's disease.

Dr Leonardo Guasti added: «It represents an entirely new concept for the study of the adrenal gland as the ability to generate donor - specific and functional adrenal - like cells will facilitate the next generation of cell - based treatments for adrenal insufficiency, the modelling of adrenal specific diseases, and the testing of personalised interventions on cells derived from patients.»

We think that prediction models like this can be very useful, if we can combine various types of data, to address chronic diseases.»

Cultural stigma against diseases that some falsely believe to be weaknesses of character prevent people from coming forward for trials — a problem when there are no good animal models for diseases like depression and schizophrenia.

The model expands the research toolkit for investigations of social behaviors and psychiatric diseases like autism and schizophrenia.

His laboratory already has shown that by inhibiting calcium channels in T - cells, they were able to prevent T - cell activation in animal models of autoimmune diseases like multiple sclerosis and colitis.

«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.

First author Antonio Di Meco and colleagues used a triple transgenic (3xTg) mouse model that displays an AD - like phenotype, including cognitive decline, and Aβ and tau neuropathology characteristic of the disease in humans.

«So now that we have seen this environmental toxicant - induced inflammation, we can study the beneficial anti-inflammatory foods, like the purple potato and others, in this human development model, and see how a mother's health and her levels of toxicants and beneficial compounds will influence the baby's susceptibility to chronic disease.»

With their experimental collaborators, the researchers are now exploring whether the algorithm can model more complex biological processes, such as the dynamics of insulin secretion in the pancreas and its relationship to the onset of a disease like diabetes.

«For example, there is a huge amount of interest and excitement globally in growing cerebral organoids» — miniature brain - like organs that can be studied in laboratory experiments — «from stem cells to model human brain development and disease mechanisms.

«Large animal models of human disease, like cats, are really helpful for determining what's going to happen in a child when you're treating them,» Vite said.

Using a model of Parkinson's disease in which the toxin MPTP, made famous in book «The Case of the Frozen Addicts,» induces Parkinson's - like symptoms in humans and mice, Dr. Smeyne showed that mice infected with H1N1, even long after the initial infection, had more severe Parkinson's symptoms than those who had not been infected with the flu.

Colorado State University biologists say this sporadic ebb and flow of prairie dog plague is an ideal model for the study of rare infectious zoonotic disease — disease that can jump from wildlife to humans — like MERS (Middle East Respiratory Syndrome) and Ebola.

In collaboration with the United States Department of Agriculture (USDA), researchers in the UPV / EHU's «Nutrition and Obesity» Group, which belongs to the Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERobn) of the Carlos III Institute of Health, have observed in animal models that its administration reduces the build - up of body fat, which could reduce the risk of developing other diseases like diabetes.

These models allow genetic dissection of calcification which is to relevant to many diseases like atherosclerosis, gout, stone and bone formation.

Interestingly, the dominant model for the mechanism by which a small molecule like a drug fits into the active site of a disease - promoting enzyme and modulates its activity is that of a «lock and key».

The work recently received a $ 1.7 million National Institutes of Health grant to delve into the mechanisms that occur as the cells reprogram, and to employ the cells for treating the Parkinson's - like symptoms in a mouse model of hypomyelinating disease.

To this aim we generated new conditional knockout mouse strains, which are currently analyzed to unravel the mechanism of a recently discovered unexpected protective role of TNFSF14 / LIGHT by our lab in an Inflammatory Bowel Disease (IBD)- like mouse model.

S. Stefanie, H Bettina, Nilges M, Schroeder S, Hoelich A, Keletzl H, Spooren W, Ostrowitzki S, Hanania T, Sendtner M, Metzger F. Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin - like growth factor I treatment depends on disease severity.

Here, Anna presents how studies of neural stem cells and neurons derived from iPS cells of patients show faithful mimicking of known disease phenotypes in our cellular models of disease, like Alzheimer's disease, autism, and Down syndrome.

It now looks like many of these traits could be controlled by the combination of genes between different strains, thus producing mice that are better models for human disease.»

«Amy's video is both beautiful to watch on an aesthetic level and beautiful to watch as an illustration of how simple model organisms like Ashbya can give us insights into human diseases like Alzheimer's,» Atkinson continues.

for example, no HD mouse model shows signs of «chorea», the dance - like movements that are a common feature of the human disease.

In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.

Sergiu P. Pasca, 36, assistant professor of psychiatry and behavioral sciences at Stanford, uses models of the human brain — created through cellular reprogramming technology — to explore the biological underpinnings of brain diseases like autism.

Because neurodegenerative disorders like PD are largely diseases of aging, modeling them in a culture dish using neurons grown from iPS cells has been thought to be exceedingly difficult, if not impossible.

If the new approach to financing research hastens the discovery of a treatment, «it can serve as a model for other hereditary forms of neurodegenerative diseases like muscular dystrophy and Huntington's disease,» he added.

For such study, we have used the McGill - R - Thy1 - APP transgenic rat, which is unique compared to other rodent models in that the AD - like phenotype has been achieved with a single genomic insertion of a mutated human APP transgene; minimizing off - target genetic corruption and therefore being closer to the human disease [32].

To study its apparent protective effect, a mouse model of the multiple sclerosis - like disease, EAE, which was also homozygous for the TYK2 mutation, led to complete protection against the autoimmune disease.

Kontoyiannis D., Boulougouris G., Manoloukos M., Armaka M., Apostolaki M., Pizarro T., Kotlyarov A., Forster I., Flavell R., Gaestel M., Tsichlis P., Cominelli F., Kollias G., 2002, «Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor - induced Crohn's - like inflammatory bowel disease», JEM, 196, 1563 - 74.

Our in vitro study provides a baseline for defining healthy and disease - like states and highlights the power of moving beyond single and dual species applications to capture key players and their orchestrated metabolic activities within a complex human oral microbiome model.

In later stages of the disease, RPE cells atrophy in both models, and drusen - like material is observed in Ctnna1tvrm5 mutants.

«In our previous work, we found that a drug - like small molecule called JQ1 can prevent the development of heart failure in mouse models when administered at the very onset of the disease.

The discovery, appearing in the December 20, 2016, issue of Cell Reports, indicates that the new model could better help scientists understand brain development as well as neurological diseases like Alzheimer's or schizophrenia.

Multiple studies show that the catechin compounds found in green tea can have various protecting effects on neurons in test tubes and animals models, potentially lowering the risk of disease like Alzheimer's and Parkinson's.

It was based, in part, on public health models that aspire, for example, to increase numbers of annual healthy births and immunized kindergarteners and decrease things like malnutrition, disease, and teen pregnancy.

That's the problem with models... you can get them to say anything you want to by adding some unjustified assumptions... things like «disease killed off 80 % of the native population» to account for the dissappearances.

Similarly, the models neglect complex coupled phenomena like the rise of diseases, invasive species, or the failure of one species as the species upon which is codepends disappears.

A study conducted by the developing team of Cardiogram app for the Apple Watch and researchers at the University of California revealed that smartwatches like Apple's own device, Garmin, or LG models, can collect data, which when analyzed by advanced tech like neural networks, can diagnose heart diseases with an accuracy of 97 percent.