Sentences with phrase «model of human disease»
Examples of applications include studies on human gene function, and creating animal models of human disease.
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Researchers have managed to insert that gene into mice to make a living, breathing model of a human disease that mice would otherwise never acquire.
The technology also has the potential to knock out specific genes to create pig models of human diseases.
Click to view article: Mouse model of human disease still good, but significant differences exist
Gladstone scientists are engineering tissues from stem cells to create better models of human disease.
Greg Barsh, a geneticist at Stanford University who studies dogs as models of human disease, says creating a transgenic dog is «an important accomplishment», showing that cloning and transgenesis can be applied to a wide range of mammals.
«Future studies need to determine the health effects of these cocoas in models of human disease and to evaluate the consumer acceptability of the cocoas as part of a chocolate product.»
The phenotyping department of PHENOMIN - ICS is advancing a technical platform for functional characterization of preclinical models of human diseases with respect to both genetic understanding of pathophysiological mechanisms and the assessment of drug therapies.
Collaborations launched at meetings have also set the stage for quieter aircraft as well as improved models of human disease, researchers said in answering a call for conference outcomes.
This new proof - of - principle experiment should open the door for transgenic dog models of human disease, says team member CheMyong Ko of the University of Kentucky in Lexington.
Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.
Research and commentary on models of human disease with significant implications for disease treatment
Mitalipov says his goal is to engineer better primate models of human disease by cloning adult rhesus monkey cells that have been genetically altered to mimic neurological and other disorders that are otherwise difficult to study in living humans or other animals.
«We now have an animal model where we can test therapies relevant to this form of TAAD and understand the behavior of this enzyme in a very specific model of a human disease.»
Thomas W Geisber, an expert on Ebola and siRNAs at The University of Texas Medical Branch, said the research was «highly significant because it shows protection against Ebola in a robust model of human disease: non-human primates.»
«We can harness the power of zebrafish genetics to create genetic models of human diseases.»
Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance.
During its Preparatory Phase, INFRAFRONTIER aimed at resolving the major issues required for implementing a sustainable INFRAFRONTIER Research Infrastructure for systemic phenotyping, archiving and distribution of mouse models of human diseases:
From accelerating the identification and validation of novel therapeutic targets, to creating better animal models of human diseases in a shorter time frame, to reducing the number of failed products, Crispr looks set to shave millions off R&D costs and boost drug discovery, she says.
She notes that biomedical researchers use macaques in part because they can offer good models of human disease.
«It has the potential to inform clinical practice and also guides us about the relevance of animal models of human disease and how we can reduce and refine their use.»
She analyzes the comparative histopathology of genetically altered mice and models of human diseases, including cancer, inflammatory disorders, and microbial infections.
«Large animal models of human disease, like cats, are really helpful for determining what's going to happen in a child when you're treating them,» Vite said.
The new Mount Sinai study reveals how loss of a protein called Sirtuin1 (SIRT1) affects the ability of blood stem cells to regenerate normally, at least in mouse models of human disease.
The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease.
«New MRI approach detects early liver tumors in mouse model of human disease.»
No, studies using animal models of human disease as well as «humanized mice» are expressly forbidden.
Facilitate communication between curators that have an interest in annotating animal models of human disease
Andrews has maintained an active NIH - funded research laboratory studying mouse models of human diseases.
«The generation of detailed phenotypic information for each knockout mouse strain will be a boon to disease researchers who want to determine the function of genes and to improve mouse models of human disease,» said NIH Director Francis S. Collins, M.D., Ph.D. «I am grateful to all of the people and programs across NIH who are supporting this effort and to our international partners who have joined us in this scientific endeavor.»
Capacity building to meet the increasing demand of the biomedical research community for systemic phenotyping, archiving and distribution of mouse models of human diseases.
OMC is a scientific and technological platform aimed at supporting R&D activities related to the validation and use of mouse models of human disease.
Dr. Hanna is a Senior Scientist in the Department of Molecular Genetics at the Weizmann Institute of Science in Israel, where he explores topics in embryonic stem cell biology, early embryonic development and the modeling of human diseases.
The findings, published recently in Nature, uphold the mouse model of human disease, but pinpoint important differences in gene expression that will guide future health research.
It creates customisable and high - scale mouse models of human disease or displaying an abnormality (KI, KO mouse models) and it provides a complete phenotyping characterisation of the immune system by polychromatic and mass cytometry measuring more than 50 simultaneous quantitative parameters in standardised conditions.
Reconstruction of transgenic and gene knockout and knockin mouse models of human diseases.
Technical approaches of mouse model of human diseases.
I am currently working on a variety of NIH - funded projects, including areas such as bioinformatics research portals, visualization for review of chart records, and tools for aiding the discovery of animal models of human diseases.
More than 200 investigators from more than 100 institutions in 17 countries have come to the MMPC to learn strategies for studying mouse models of human disease.
I am particularly pleased that the fundamental knowledge of gene function and the derivation of animal models of human disease are underpinning important therapeutic advances.
The Jackson Laboratory Research scientist / Animal models of human disease, Mouse Mutant Resource, Genetic Resource Science 2006 - present
KOMP2 postdoctoral fellows will work collaboratively to screen and characterize an expected 30 % of embryonic lethal mutants from more than 800 mouse strains that JAX is characterizing as part of an international effort to functionally annotate the mouse genome and generate mouse models of human disease.
Research in laboratory animal medicine (also referred to as comparative medicine) includes the study of animal diseases, animal models of human disease, computer modeling, procedural and surgical techniques, and animal nutrition.