Sentences with phrase «model of the disease developed»

For this study, Jabri and colleagues combined insights and data from celiac disease patients who had been cared for at the University of Chicago's Celiac Disease Center with experiments using a mouse model of the disease developed in her lab.

Not exact matches

Of note, our models may underestimate the true maternal costs of suboptimal breastfeeding; we modeled the effects of lactation on only five maternal health conditions despite data linking lactation with other maternal health outcomes.46 In addition, women in our model could not develop type 2 diabetes mellitus, hypertension, or MI before age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some studies have found an association between lactation and rates of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and MOf note, our models may underestimate the true maternal costs of suboptimal breastfeeding; we modeled the effects of lactation on only five maternal health conditions despite data linking lactation with other maternal health outcomes.46 In addition, women in our model could not develop type 2 diabetes mellitus, hypertension, or MI before age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some studies have found an association between lactation and rates of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and Mof suboptimal breastfeeding; we modeled the effects of lactation on only five maternal health conditions despite data linking lactation with other maternal health outcomes.46 In addition, women in our model could not develop type 2 diabetes mellitus, hypertension, or MI before age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some studies have found an association between lactation and rates of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and Mof lactation on only five maternal health conditions despite data linking lactation with other maternal health outcomes.46 In addition, women in our model could not develop type 2 diabetes mellitus, hypertension, or MI before age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some studies have found an association between lactation and rates of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and Mof postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and Mof lactation's effect on both diabetes and MI.

And researchers have developed a wide range of sophisticated computer models that simulate human biology and the progression of developing diseases.

Medicines that are personally tailored to your DNA are becoming a reality, thanks to the work of U.S. and Chinese scientists who developed statistical models to predict which drug is best for a specific individual with a specific disease.

Benjamin «Benjy» Firester, 18, of New York City, won the top award of $ 250,000 for developing a mathematical model that uses disease data to predict how weather patterns could spread spores of late blight fungus, which caused the Irish Potato Famine.

The company provides porcine models of particular diseases, models that are used to develop gene - based treatments and drugs.

To develop their «disease in a dish» model, the team took skin cells from patients with Allan - Herndon - Dudley syndrome and reprogrammed them into induced pluripotent stem cells, which then can be developed into any type of tissue in the body.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in general.

Using iPSCs, researchers developed a novel cellular disease model to probe the neurobiological causes of schizophrenia, which are not well understood (ChangHui Pak, abstract 032.29, see attached summary).

The sheep model of Huntington's disease has been developed to increase knowledge about Huntington's disease.

Known as a triple transgenic model, the animals develop three key characteristics of the disease: memory impairment, amyloid plagues, and neurofibrillary tangles.

To study the pathogenesis of HIV - induced PNS disease, Jamie Dorsey, Research Technologist, and the research team led by Dr. Mankowski developed a simian immunodeficiency virus (SIV)- infected macaque model that closely reflects key peripheral nervous system (PNS) alterations seen in HIV patients with peripheral neuropathy.

With the FFI and CJD models in hand, Jackson says he's excited to investigate how the pathology of these diseases develops.

When the weather - based model developed at Rothamsted Research was used to predict how climate change may affect the wheat crops, it was predicted that wheat flowering dates will generally be earlier and the incidence of the ear blight disease on the wheat crops will substantially increase.

Nath's team is currently developing an animal model of Nodding syndrome to further study the disease and test potential therapies.

A promising new avenue for treating hepatitis B has been reported by researchers at Hiroshima University who have developed a new animal model of the disease.

Most importantly, these cells protected mice from developing diabetes in a model of disease, having the critical ability to produce insulin in response to changes in glucose levels.

University of Adelaide researchers have developed a computer simulation model which supports the theory that sexual reproduction evolved because of the presence of disease - causing microbes and the need to constantly adapt to resist these co-evolving pathogens.

The researchers developed a model of Alzheimer's disease and were surprised to find that increased levels of a gene involved in the production of toxic proteins in the brain not only led to Alzheimer's - like symptoms, but also to the development of diabetic complications.

Now, a team of scientists at the Icahn School of Medicine at Mount Sinai have developed the Just EGFP Death - Inducing T - cell, or JEDI T - cells, which enable the visualization of T - cell antigens, allowing researchers to study T - cell interactions with different cell types, model disease states, and finally determine the functions of otherwise poorly characterized cell populations.

Previous models, however, have been unable to explain why only 10 percent of women develop the disease when most experience retrograde menstruation at some point.

He returned to St. Louis and shifted several members of his lab to studying Zika, including developing mouse models of the disease.

The prevalence model, developed by RTI for the United States Centers for Disease Control and Prevention, illustrates some of issues the nation will face as diabetes rates increase and Americans live longer.

The new Penn - developed model replaces a previous model that only examined pre-operative features such as a history of chronic obstructive pulmonary disease, congestive heart failure, or coronary artery disease.

Reported today in Disease Models & Mechanisms, Karim Si - Tayeb and colleagues in the research group of Bertrand Cariou from l'Institut du Thorax, Nantes used an innovative approach to develop unique patient cell - based models of PCSK9 - driven hypercholesteroModels & Mechanisms, Karim Si - Tayeb and colleagues in the research group of Bertrand Cariou from l'Institut du Thorax, Nantes used an innovative approach to develop unique patient cell - based models of PCSK9 - driven hypercholesteromodels of PCSK9 - driven hypercholesterolemia.

To test whether fatty acid levels in the bloodstream was a cause or a consequence of disease, the researchers turned to a zebrafish model of Crohn's disease that had been developed by Stefan Oehlers, a post-doctoral fellow in David Tobin's group at Duke.

Using data from the outbreak of cholera that started in 2010 in the region, they developed a mathematical model of the disease's epidemiology.

Potential outbreaks of diseases such as Ebola and Lassa fever may be more accurately predicted thanks to a new mathematical model developed by researchers at the University of Cambridge.

Using a recently developed genome - editing technique called CRISPR, a Chinese team has successfully altered two target genes in cynomolgus monkeys, paving the way for the development of monkey models that mimic human diseases.

Scientists have developed the first true animal model of Huntington's disease, a progressive and often fatal deterioration of the central nervous system.

He is also developing a robust and comprehensive panel of 3 - D cell culture models from patient - derived primary cells that can be used to characterize different disease phenotypes and investigate the chemo - response of cells to novel or known drugs.

The new finding is the latest evidence supporting a growing precision medicine model of psychiatric disease in which disruptions of certain genes during brain development contribute to a person's risk for multiple psychiatric disorders, with other genetic or epigenetic drivers, random developmental events, or environmental influences determining the specific disease an individual develops, said senior author Benjamin Cheyette, MD, PhD, an associate professor of psychiatry and a member of the UCSF Weill Institute for Neurosciences and the Kavli Institute for Fundamental Neuroscience at UCSF.

However, in a few developing countries, model TB - control programmes supported by the International Union against Tuberculosis and Lung Disease may be limiting the spread of TB.

Her lab is now developing a model system for Parkinson's disease that includes brain, liver, and gastrointestinal tissue, which she plans to use to investigate the hypothesis that bacteria found in the gut can influence the development of Parkinson's disease.

One of the most promising avenues for developing a cure, however, is through gene therapy, and to create those therapies requires animal models of disease that closely replicate the human condition.

First, the researchers developed a model of Parkinson's in zebrafish — the first such animal model of the disease — and exposed them to ziram so that they lost dopamine.

The monkey model has its own limitations: Monkeys don't develop severe disease when infected with different serotypes of dengue virus, which clearly happens in humans.

Kanta Subbarao of the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, said her group has had to stop its efforts to adapt the MERS virus to mice to develop an animal model for the disease.

Noting the potential of gene therapy to be a one - time treatment for rare and serious diseases that otherwise cost hundreds of thousands, if not millions, of dollars in chronic care over a lifetime, Stuart Orkin, MD, and co-author Philip Reilly, MD, JD, of Third Rock Ventures, seek to «catalyze the discussion» by suggesting several new models for valuing, pricing and developing gene therapy.

The discovery was made by developing a mouse model of the disease that enabled researchers to track which of 15 genetic groups — or subclones — of myeloma cells spread beyond their initial site in the animals» hind legs.

To study the still unknown pathogenesis of the disease, the researchers developed a mouse model susceptible to the full range of infection by the human parasite.

The authors developed a mathematical model accounting for disease progression, mortality, morbidity and the heterosexual transmission of HIV to help forecast future trends in the disease.

By tuning the model to replicate population data, such as the number of people at risk for developing TB and the fraction of TB patients who have drug resistance, the model can predict changes in the TB disease burden — or number of cases — over many years.

The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease.

Researchers from the Institute of Neuroscience at the Universitat Autònoma de Barcelona have discovered the cellular mechanism involved in memory consolidation and were able to develop a gene therapy which reverses the loss of memory in mice models with initial stages of Alzheimer's disease.

This technology has been developed from a skin explant model for predicting a potentially serious complication of bone marrow transplantation, «graft versus host» disease — a common complication following the transplant.

Prof. Jean - Christophe Marine (VIB - KU Leuven) and others developed mouse models recapitulating some of the key histopathological features of the human disease.

«In collaboration with researchers from the University of Calgary and the University of British Columbia our team has developed a computer model to help doctors and their patients better understand how excess body weight contributes to reduced life expectancy and premature development of heart disease and diabetes,» says lead author Dr. Steven Grover, a Clinical Epidemiologist at the RI - MUHC and a Professor of Medicine at McGill University.

In collaboration with the United States Department of Agriculture (USDA), researchers in the UPV / EHU's «Nutrition and Obesity» Group, which belongs to the Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERobn) of the Carlos III Institute of Health, have observed in animal models that its administration reduces the build - up of body fat, which could reduce the risk of developing other diseases like diabetes.

Dr. Grover and his colleagues used data from the National Health and Nutrition Examination Survey (from years 2003 to 2010) to develop a model that estimates the annual risk of diabetes and cardiovascular disease in adults with different body weights.