Sentences with phrase «model of the disease further»

Strong evidence from a mouse model of the disease further confirms these mutations as a cause of aortic disease, and, together, the results point toward possible strategies for managing this inherited form of TAAD.

Not exact matches

Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

Nath's team is currently developing an animal model of Nodding syndrome to further study the disease and test potential therapies.

«This mouse model also will be useful in studies to further investigate impact of the omega - 3 omega - 6 ratio in disease prevention and treatment.»

She and her colleagues will be exploring the role of YY1 further, using clinical samples as well as mouse models, to look at the protein in diseases like lupus to deepen their understanding of how autoimmunity could result from the «escape» of immune genes from X chromosome inactivation.

The success of both vaccines thus far in stringent monkey models has led Picker and his colleagues to believe their CMV - based approach to making vaccines has the potential to be engineered to tackle a variety of infectious diseases.

«This study, carried out using laboratory rats modeling stroke, demonstrated that ischemic stroke — in both its subacute and chronic stages — damages the BSCB in a variety of ways, creating a toxic environment in the spinal cord that can lead to further disability and exacerbate disease pathology,» said study lead author Dr. Svitlana Garbuzova - Davis, associate professor in USF's Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair.

While the mouse study does not prove a direct connection between Zika infection and microcephaly, Rossi said, it does underscore the urgent need for effective animal models to further study the course of disease and its transmission.

Researchers at RTI International will continue to further refine their model to incorporate other national health issues, such as obesity, and to also assess how positive interventions could alter the course of kidney disease in America.

In a further step, the researchers used mathematical models to predict how an infectious disease would spread considering the changes in behaviour of the sick animals.

«The next stage would be to repeat the study in primates, a more suitable animal model where HIV infection induces disease, in order to further demonstrate elimination of HIV - 1 DNA in latently infected T cells and other sanctuary sites for HIV - 1, including brain cells,» Dr. Khalili said.

Research on Huntington's has thus far relied heavily on animal models of the disease, and has left many key questions unanswered.

The researchers hope their new cell lines will be a useful resource for studying the cellular and molecular intricacies of Huntington's further, and suggest they may provide a model for examining other diseases of the brain that are specific to humans.

Taking this one step further, the researchers performed the same experiments in a mouse model of Alzheimer's disease to see if these astrocytic adenosine receptors were also involved in memory loss associated with the disease.

This discovery provides a significant opportunity not only to enhance our understanding of how miRNAs regulate a variety of biological processes in an important model species for studying human diseases, but can lead to further, similar research into the role that miRNAs play in animal domestication.

These quantifications might further help, and indeed convince, decision - makers across the world to decide on wide - scale introduction of prediction models and risk - based management for cardiovascular disease.»

The similarity of the mouse and human genetic make - up means that genes associated with disease in humans can be studied and further investigated in mouse models.

Further, future studies will take advantage of the induced non-human primate animal model of endometriosis allowing for the measurement of microbial changes throughout disease progression.

Although further refinement and testing is needed, Dr. Burgess said the new techniques have the potential to speed the production of many different types of transgenic animal models that will shed new light on human development and disease.

This paper provides direct evidence for the role of TNF in chronic intestinal inflammation using TNBS colitis in Tg197 mice as a model and encourages further clinical trials with anti-TNF therapeutics for the treatment of Crohn's disease.

Career Goals: I hope to further pursue graduate school to earn a PhD and to continue learning about the molecular biology of Tregs in a variety of contexts and disease models.

The team further found that disruptions to this process occur in mouse models of Alzheimer's disease — and identified two therapeutic strategies that reduce these disruptions.

In further studies, for which Proclara received support from the Michael J. Fox Foundation, NPT088 reduced levels of alpha - synuclein aggregates in an animal model of Parkinson's disease.

The two labs are now collaborating on further studies of the new enzymes — and the potential benefits of inhibiting them — in mouse models of diabetes, inflammation and autoimmune disease.

Akassoglou's laboratory uses mouse models of blood - driven neural inflammation and autoimmunity to explore further the role of fibrinogen in MS, and she is now pursuing similar lines of investigation on other neurological diseases.

So far, we've seen gene silencing drugs tested in several different animal models of Huntington's disease, successfully delaying symptom onset or even reversing symptoms.

A new and more disease relevant animal model of diabetes polyneuropathy, the ZDF model, has now been further validated and compared to other models of diabetes polyneuropathy.

Further, the brain benefits of vitamin D have also been described in several experimental models, indicating the potential value of vitamin D in helping neurodegenerative and neuroimmune diseases.

In Singapore, cancer is still seen as a terminal disease with little hope of recovery, and there is also a stigma against psychological counselling and psychiatric support, facilitated by the general stigma against mental illness amongt both patients and, paradoxically, healthcare professionals.67 Furthermore, a family - centred model of decision - making tends to be predominant in Asian populations, 68 and in Singapore this is further encouraged by public policy such as healthcare subsidies that are based on a calculation of the immediate family's total income, rather than individual income.69 Beliefs or expectations of the role that the family caregiver ought to play may thus exist and may influence the way individuals respond to the intervention.

They have taken the treatment of anxiety disorders far beyond the disease model that CBT has been stuck in by brilliantly examining the core psychological processes that make fear and anxiety disordered and explaining in clear language what all anxiety disorders have in common.