Sentences with phrase «model of this disease called»

In 1998, Greg Cox identified the first mouse model of this disease called nmd2J which is still the only model of SMARD utilized for research.

Not exact matches

Specifically, the Mount Sinai study was designed to test whether pharmacological compounds designed to block the function of XPO1 / CRM1 could stop disease progression in mouse models that exhibit some of the characteristics of MS. Researchers found that two chemical agents (called KPT - 276 and KPT - 350) prevented XPO1 / CRM1 from shuttling cargo out of the nucleus of nerve cells, which protected them from free radicals and structural damage.

Using a recently developed genome - editing technique called CRISPR, a Chinese team has successfully altered two target genes in cynomolgus monkeys, paving the way for the development of monkey models that mimic human diseases.

The researchers used mouse models that mimic the disease characteristics of pulmonary hypertension and pulmonary fibrosis in humans to study the effect of triciribine, which inhibits production of a protein called Akt1.

By depriving the cancer cells of the amino acid cystine, the researchers were able to trigger a form of cell death called necrosis in mouse models of the disease.

The new Mount Sinai study reveals how loss of a protein called Sirtuin1 (SIRT1) affects the ability of blood stem cells to regenerate normally, at least in mouse models of human disease.

Investigators led by Suma Prakash, MD, FRCPC, MSc (Case Western Reserve University) wondered whether a model called the «behavioral stage of change» model, which was originally used to help people quit smoking, might help patients with chronic kidney disease take action and make decisions about their dialysis options.

This call aims to create and caracterise consitutive (Ko) and conditional Knock - Out (cKO), Knock - In (KI) and transgenic (TG) mouse models in the field of rare diseases.

This joint call for projects «Mouse models and rare diseases» aims to give a significant boost to the development of mouse models, in order to:

This 2nd joined call supported the creation and the characterization of murins models of rare diseases: Knock - Out constitutive (KO) / conditional (cKO), Knock - In (KI) and transgenic mice -.

The call for projects «Mouse models and rare diseases» aims to give a significant boost to the development of mouse models, in order to:

The French Foundation for rare diseases (Fondation maladies rares) and the French National Infrastructure PHENOMIN are pleased to launch their 3rd joint call for the creation and exploration of mouse models for rare diseases.

This call for projects «Mouse models and rare diseases» aims to give a significant boost to the development of mouse models, in order to: ◊ gain a better understanding of the pathophysiological mechanisms involved in rare diseases whose defective genes have been identified ◊ test and validate therapeutic proofs of concept, at the pre-clinical in vivo level Indeed, producing these models meets a key objective in the development of a therapeutic strategy.

Researchers call this model of causal factors of schizophrenia the «diathesis — stress» model, where «diathesis» means a hereditary predisposition to a disease.

For example, he discovered that reducing levels of a protein called tau can prevent cognitive deficits in animal models of the disease.

In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.

These plaques are extracellular aggregations of a small protein called beta - amyloid that are prominent in diseased patients» brains, as well as in mouse models of the disease.

Working with Ye, postdoctoral fellow Sung - Wuk Jang identified a compound called 7,8 - dihydroxyflavone that can duplicate BDNFâ $ ™ s effects on neurons and can protect them against damage in animal models of seizure, stroke and Parkinsonâ $ ™ s disease.

This call for projects «Mouse models and rare diseases» aims to give a significant boost to the development of mouse models, in order to:

The French Foundation for rare diseases (Fondation maladies rares) and the French National Infrastructure PHENOMIN has conjointly launched calls for the creation and exploration of mouse models for rare diseases, for 4 years.

A new study shows that increasing the activity a critical piece of machinery called «mTORC1» in a mouse model of Huntington's disease leads to improved motor problems and brain abnormalities associated with the disease.

This call for proposals aims to establish and characterize mouse models: conditional Knock - Out (cKO), Knock - In (KI) and transgenic (TG) in the field of rare diseases.

The unit focuses its attention on selected models as mother - to - child transmission of HIV - 1 or HIV infected patients controlling the disease or the virus, called Elite and Virus controller.

«In our previous work, we found that a drug - like small molecule called JQ1 can prevent the development of heart failure in mouse models when administered at the very onset of the disease.

THE MOUSE MODEL FOR CYSTIC FIBROSIS, as with models for many diseases, owes its existence to a technique called gene targeting, which was developed in the 1980s by Mario Capecchi, a professor of human genetics and biology at the University of Utah who won the 2007 Nobel Prize in Physiology or Medicine for his work.

Using a mouse model for this disease, which in humans involves the destruction of white matter in the brain, a research team led by Albee Messing, director of the UW — Madison Waisman Center, found that a protein behind the symptoms of the disease, called GFAP, is broken down more rapidly in the body than researchers previously found in cell culture studies.

Conventional medicine, as you called it earlier, was created in response to mainly acute disease where you have a single cause and single effect, and now medicine is trying to adapt to this now environment of chronic disease, which is driven by lifestyle, it's multi-systemic, it's across many different organs, and so that linear model of thinking doesn't really work.

The so - called «Touch Disease» affects a large number of Apple iPhone 6 and Apple iPhone 6 Plus models, and users can easily identify it.