Sentences with phrase «model organism approach»

It «just screamed that it would be an example that would fit really well with this model organism approach.»

Not exact matches

«The whole value of model organisms is that they are lean and mean,» so once he has established his proofs of principle, ideally he will be able to use a matrix approach to efficiently tackle many rare diseases simultaneously.

Traditional genetic approaches together with the new wealth of genomic information for both human and model organisms open up strategies by which drugs can be profiled for their ability to selectively kill cells in a molecular context that matches those found in tumors.

Given the rapid succession of generations in yeast, we can use it as a model organism — and study the mechanisms of aneuploidy in much greater detail to find out whether we can derive from it new approaches for diagnosing and treating human diseases.»

This approach opens new avenues for research into memory using zebrafish as model organism,» concludes Dr. Okamoto.

«It integrates all processes responsible for organism success and requires a systems science approach to understand it, complete with observations and coordinated models.

The project takes advantage of yeast as a model organism and several reconstitution approaches to understand the particular function of the involved proteins.

We focus on several model organisms in the laboratory but are open to additional approaches by independent - minded and motivated individuals.

Now, the use of diverse model organisms to explore human disease is truly starting to gain the recognition it deserves as a scientific approach.

Since ants are not afforded the molecular and genetic tools of traditional model organisms, we will begin addressing the question of colony queen number with a functional genomics approach.

Subsequent validation experiments in model organisms will test if and how the elements pinpointed by the computational approaches are involved in changing molecular and morphological phenotypes.

We address these questions by combining genetics with live imaging, quantitative image analysis and biophysical approaches using the fruit fly Drosophila melanogaster as a model organism.

As bioinformatics approaches can only provide partial solutions, a functional analysis pipeline, based on primary (fibroblast) cell cultures, induced Pluripotent Stem cells (iPS) or simple model organisms, is truly essential.

New approaches to microscopy, precision laser ablation of individual cells and capillaries, and genetic engineering of model organisms are opening new vistas for exploring the brain and how it works.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

Gene disruption in cells and model organisms followed by phenotypic analysis has been a traditional approach to understand gene function.

We have taken a large - scale, multi-organism approach to address the question of which genes and pathways identified in model organisms are most likely to be relevant for human aging.