The CRISPR - Cas9 technology allows researchers to transiently introduce DNA double - strand breaks into the genome of cells or
model organisms at genes of choice.
Transparent eggs and fry are «ideal for getting light in and getting light out,» notes Eric Edsinger, who develops
model organisms at the Marine Biological Laboratory in Woods Hole, Mass..
Not exact matches
But the reason this research is so momentous has very little to do with bacteria
at all, rather it signals the beginning of
modeling organisms.
Birch and Cobb maintain that the ecological
model is more adequate than the mechanical
model for explaining DNA, the cell, other biological subject matter (as well as subatomic physics), because it holds that living things behave as they do only in interaction with other things which constitute their environment (LL 83) and because «the constituent elements of the structure
at each level (of an
organism) operate in patterns of interconnectedness which are not mechanical» (LL 83).
Her interest was piqued: Upon graduating in 1999 she joined the lab of Ding Xue
at the University of Colorado, Boulder, to study how cell death is regulated in the
model organism Caenorhabditis elegans.
You have to be able to see something
at the bedside and think of how you can address it in a
model organism or some kind of detailed biochemistry experiment in the laboratory.
She did her master's degree research project
at the Institute of Biochemistry and Biophysics (IBB), also in Warsaw, looking
at the effect of genetic mutations on the function of an enzyme involved in the biosynthesis of heme, using Saccharomyces cerevisiae as a
model organism.
When looking for
model organisms, Edsinger explains, it's a real boon to be able to keep many in the lab
at once.
He presented his idea one day to a roomful of about 30 colleagues
at Yale's «Worm Meeting,» the weekly gathering for researchers studying C. elegans, the lowly nematode widely used as a
model organism in developmental biology.
But the few predictive
models are still hotly debated, and they apply to only a narrow range of
organisms at best.
The report, which drew heavily on two Environmental Protection Agency (EPA) workshops held in 1995, also recommends more research on such topics as DNA biomarkers that can gauge an
organism's exposure to endocrine disruptors;
models for predicting how endocrine disruptors are metabolized; mechanisms of how endocrine disruptors act
at a cellular level; and the effects of mixtures.
Certain mental phenomena might be explained and
modeled with computers; the most fashionable candidates
at the moment envision thoughts competing in the brain like
organisms in the wild.
The fruit fly Drosophila melanogaster has a life expectancy of approx. 8 weeks and belongs to the
model organisms studied by scientists
at the Max Planck Institute for Biology of Ageing in their quest to understand aging in living beings.
Knowing these larvae respond to odors but not fully understanding the process by which they make decisions via olfactory cues, scientists
at UC Santa Barbara are using this
model organism to study brain function as it relates to behavior control.
«Pikas are a
model organism for studying climate change, and their decline
at low - elevation sites suggests that the future for other species is not great either,» Stewart said.
Different
model organisms like the fruit fly Drosophila melanogaster are used for their research, aimed
at decoding the principles of stem cell control with the aim to also apply them to higher forms of life and eventually humans.
She has been a co-principal investigator for the
model organism database FlyBase
at Harvard.
During panel discussions Sept. 18
at 6, 7 and 8 a.m. PDT (9, 10 and 11 a.m. EDT), scientists and researchers will discuss the various science and research studies, including RapidScat, 3 - D printing in Zero - G, technology to measure bone density, and
model organism research using rodents, fruit flies and plants.
By creating MARRVEL (
Model organism Aggregated Resources for Rare Variant ExpLoration) they are now able to help not only their own lab but also researchers everywhere search databases all
at once and in a matter of minutes.
Using the Drosophila melanogaster fruit fly as a
model organism, the team led by Prof. Dr. Ingrid Lohmann
at Heidelberg University's Centre for Organismal Studies was able to show how a special developmental gene from the Hox family influences germline stem cells.
«Using the anti-cancer drug and a replication inhibitor, hydroxyurea, in the
model organism Saccharomyces cerevisiae, we observed that double strand breaks preferentially occurred
at hydroxyurea - induced genes,» said Feng.
His group studies the cellular and genetic control of gastrulation movements in zebrafish, one of the
model organisms studied
at the institute besides Drosophila, the C. elegans worm, frogs, mice, and newts.
The researchers analysed neurogenesis
at the molecular level in the
model organism Nematostella vectensis.
Niyogi worked on identifying tryptophan biosynthesis pathways in Arabidopsis, which
at the time was a relatively new
model organism.
«It is not a good genetic
model organism, but it does regenerate — and that makes it an awesome biological
model,» says David Gardiner, a developmental biologist
at the University of California, Irvine, who has studied axolotl regeneration for decades.
NASA will host a prelaunch panel discussion
at 8 a.m. PDT Sept. 18,
at the agency's Kennedy Space Center in Florida, featuring scientists and researchers who will discuss various science and research studies, including the four Ames - supported payloads to study
model organism research using yeast, rodents, fruit flies and plants.
This program, McKnight Technological Innovations in Neuroscience Awards, focuses on «how technology may be used or adapted to monitor, manipulate, analyze, or
model brain function
at any level, from the molecular to the entire
organism.»
Researchers
at the Universities of Edinburgh and NYU Langone Medical Center have developed two types of molecular switch that work in yeast, a commonly used
model organism.
The team of Luis Lopez - Molina, professor
at the Department of Botany and Plant Biology of UNIGE's Faculty of Science, Switzerland, has been interested for a long time in the mechanisms controlling germination, arguably the most critical decision in the life of a plant: «We have discovered that the genes involved in the synthesis of cutin, a waterproof substance, are important for the maintenance of dormancy in seeds of Arabidopsis thaliana, a small plant widely used as a
model organism to study plant biology.
Collins used a new analysis performed by NIH staff to address concerns expressed by many of the
model organism researchers gathered
at TAGC, particularly a 2015 analysis by Michael Wangler, Keith Yamamoto, and Hugo Bellen that suggested NIH grant support for Drosophila research is declining.
Collins also discussed funding of
model organism databases, citing the open letter for support of these key resources, which had over 11,000 signatures
at the time of his talk.
Last week
at The Allied Genetics Conference (TAGC), National Institutes of Health (NIH) Director Francis Collins provided an overview of
model organism support from his agency.
The Microbiology Services Division
at Porton Down, part of the National Infection Service directorate, has extensive high - containment laboratory facilities and rare capabilities to handle infectious
organisms under the highest levels of containment, and the ability to work with in vivo
models to evaluate new therapeutic interventions against these
organisms.
In the 1970s, George Streisinger, a scientist
at the University of Oregon, was interested in using a vertebrate
model organism that was simpler than the mouse and easy to manipulate genetically.
At the end of his talk, Collins urged researchers to continue to ask congress to fund more for fundamental research, arguing that increased, sustainable funding will help maintain support for
model organisms, and the biomedical advances that depend on them
At Hampshire College, students and faculty use the amoeba Physarum polycephalum — both a «visiting scholar» and a
model organism — to examine human societal and political quandaries.
These tools will help to better understand ongoing changes in chemical and biological state of the North Sea from alkalinity fluxes originating from the Wadden Sea over a synthesis
model that integrates OA sensitivities
at organism level into a North Sea ecosystem
model (5.1) to an economical impact assessment.
Develop a framework for integrating ocean acidification sensitivities
at the
organism level into ecosystem
models.
During his SRF - sponsored internship
at the Buck Institute for Research on Aging, Brandon helped develop a
model to study the coordination of tissue aging throughout an
organism in the laboratory of Dr. Henri Jasper.
Trainings to generate genetically modified
models in specific
organisms will be provided on different sites according the speciality: zebrafish
model at AMAGEN (Gif - s - Yvette), rat
model at the TRIP (Nantes) and mouse
model at Anexplo (Toulouse).
Last week
at The Allied Genetics Conference (TAGC), National Institutes of Health (NIH) Director Francis Collins provided an overview of
model organism support from his...
Clocking in
at 302 neurons, it is one of the simplest
model organisms to possess a nervous system.
Transgenic and gene knockout / knockin technologies have become important experimental tools for assigning functions to genes
at the level of whole complexity of
organism, creating
models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.
One such study from last year looked
at Bacillus subtilis, a common soil bacterium which has become a
model organism for experiments and holds the record for space survival after spending six years on NASA's Long Duration Exposure Facility spacecraft.
Inspired by a 2009 FCL team retreat and field trip to Mistaken Point, Newfoundland, coauthors David Jacobs, Roger Summons, David Johnston, and Marc Laflamme used
models of canopy flow to explain how sticking up into the water column provided rangeomorphs, some of these earliest multicellular
organisms preserved
at Mistaken Point, a competitive advantage over microbial mats.
Now in her final year
at Oxford, Mehera spends most of her time in the lab studying DNA repair in the
model organism Dictyostelium, a slime mold with proteins that may inform human cancer research.
Our group focuses on this question and uses the cnidarian Nematostella vectensis as a
model organism to study how such morphological plasticity mechanisms are encoded
at the molecular and cellular level.
Genomics of
model organisms and human biology: Insights from the modENCODE Project, will be held on June 20 - 21, 2012
at NIH's Natcher Auditorium.
Dr. Andrew Hill: But eventually and — and so caloric restriction is the only biohacking modality that's been proven to actually affect aging, but in
model organisms, it does do it
at the cost of metabolic output and it probably --
If you have ever seen the computer
models used to look
at this, it is quite apparent that removing any
organism can restructure, damage, or destroy certain ecosystems.