Sentences with phrase «model small cell»

«As a model small cell type, we used a cancer cell whose size is around 24 micrometers, and achieved 98.9 % purity, 90.7 % viability, and a 97.8 % success rate.»

Not exact matches

Some models have only a small pouch for a cell phone or bottle, but there are others loaded with pockets, pouches, and toy loops built into the waist belt.

«We are very excited about the prospect of using these more physiologically relevant cell - based models for gene and small molecule drug discoveries,» says Dr. Andrew Liu, Assistant Professor of Biology at the University of Memphis.

In the study, exosomes, which are generated by all cells and are naturally present in blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse models.

Research in the laboratory of Rebecca Wingert, the Gallagher Family Associate Professor of Adult Stem Cell Research in the Department of Biological Sciences at the University of Notre Dame, has confirmed the key role of a certain small molecule in the development of kidney structures in zebrafish, a widely used model for human kidneys.

One postdoc presents data on her efforts to develop an organoid model for small - cell lung cancer; another reports progress on culturing hormone - secreting organoids from human gut tissue.

The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue.

«The cell model could be a platform to look for small molecular drugs that would inhibit pathology.»

They found that, by using math models to understand the complex dynamics within cancers, they could use small changes in the environment to promote the growth of cells that are less aggressive and thereby decrease tumor growth.

The study revealed that in the model system chosen by Opitz and colleagues the winning side becomes apparent at a very early stage in the growth of the population, when the numbers of cells are still relatively small.

The researchers used computer models to predict that small changes of the pH within the tumor could tip the balance, decreasing the survival advantage of the invasive cells in favor of the non-invasive cells.

While the observed differences of the individual steps were mostly modest, mathematical modeling suggested that even small delays in the trafficking of these immune cells will lead to reduced initiation of a WNV - specific antibody - response during the early stages after infection.

Daimler began manufacturing a small series of this model in late 2009, then quickly decided to make it the first fuel cell passenger car it would mass - produce.

If the work proceeds as expected, «all interactions between genes, proteins, and small molecules will be revealed, and the whole cellular network will be reconstructed,» says Igor Goryanin, who heads cell modeling at GlaxoSmithKline in Stevenage, U.K.

The cells generated in the Zeng lab may not only provide a potential unlimited source for cell replacement therapy for Parkinson's disease, but also offer an unprecedented opportunity to develop screening models for assessing small molecule drugs and to clarify the mechanisms of disease.

For these purpose, we explore and validate the use of cell progenies derived from pluripotent stem cells to produce disease models in a dish, to screen for compounds (small molecules, biologicals, etc).

Phenotypic approaches screen for the effects of small molecules on an observable characteristic of an animal, tissue or cell model, typically without a priori knowledge of the target.

We use the zebrafish model to study β - cell development due to the small size and optical transparency of its embryos / larvae, as well as the ease of the genetic and chemical - genetic manipulations, including the ability to conduct large - scale small molecule screens.

«Techniques like this tend to have a democratizing effect,» opening up opportunities for smaller groups, Molly Maleckar, the director of mathematical modeling at the Allen Institute for Cell Science who was not involved in the study, tells Wired.

This model system recapitulates physiological events associated with chemotaxis including gradient sensing and pseudopodial protrusion through small openings in the vessel wall during cancer cell metastasis.

A secretagogue — small interfering RNA conjugate confers resistance to cytotoxicity in a cell model of Sjögren's syndrome.

To better understand this complex tissues and its functions — and the diseases that affect it — a multicenter team led by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital has released a census of the cells that make up the lining of the small intestine, using gene expression profiles of more than 53,000 individual cells from the mouse gut or gut organoid models.

Navitoclax Enhances the Efficacy of Taxanes in Non — Small Cell Lung Cancer Models.

Finally, we show that addition of small molecule inhibitors of eIF2α dephosphorylation to muscle stem cell cultures permits their ex vivo expansion and engraftment into a preclinical mouse model of Duchenne muscular dystrophy.

We are interested in the role of secretory chaperones in the biochemistry and cell biology of the neuron and have shown that two small secretory chaperones can block the formation of both Abeta oligomers and fibrils in vitro and neurootoxic aggregates in cell culture models.

Murine gammaherpesvirus 68 infection of IFNγ unresponsive mice: a small animal model for gammaherpesvirus - associated B - cell lymphoproliferative disease.

We have used a variety of cell models to test toxicity, cell penetration, and efficacy of furin inhibitors, and have identified small molecule inhibitors selective for cell surface furin action as well as inhibitors which also work intracellularly.

Previous work has given insights into the mechanistic pathways leading to small molecule sequestration in membrane - free coacervate protocells; successfully demonstrated the use of liquid - liquid phase separated micro compartments for protein expression using cell free expression systems; exploited microfluidics for the high throughput formation of stable, monodisperse microdroplets; and integrated two contrasting modes of protocell construction to produce a novel hybrid model based on fatty acid membrane - bound coacervate micro-droplets.

To sidestep the shortcomings of currently used cancer models, the Salk team harnessed the power of lentiviral vectors to infect nondividing as well as dividing cells and ferry activated oncogenes into a small number of cells in adult, fully immunocompetent mice.

Verma has successfully developed lentiviral vector - mediated mouse models for glioblastoma, lung adenocarcinoma and small cell lung cancer (SCLC).

Life tables were used to model five year survival for early stage non-small cell lung cancer and limited stage small cell lung cancer, using death rates for continuing smokers and quitters obtained from this review.

In small cell lung cancer, starting from bioinformatics analyses of large gene expression datasets, we clustered subsets of co-expressed gene modules, derived networks of transcription factors and simulated their dynamics using logic - based mathematical modeling.

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In our context of root growth, the Timer model could drive similar outcomes as the Sizer model only under very restrictive conditions of small variability in the threshold time and the cell elongation rate, suggesting it is a less plausible scenario.

Current work focuses on identifying novel Eph receptor - targeting agents (such as peptides and small molecules) as well as improving the existing ones in collaboration with medicinal chemists and structural biologists, and evaluating them in cell culture and in vivo animal models.

Dr. Hackam's team has developed techniques of intestinal stem cell isolation and culture, and are working with tissue engineers and chemists towards the development of an artificial intestine, which has been tested in large and small pre-clinical models.

While the small changes in lineage transcription observed in our data set would be consistent with a stochastic model, the ES cell model described in Figure 9 would require both cross-repression and additional positive feedback loops to drive these random changes in gene expression down multiple distinct routes.

With this study, the scientists found that JQ1 can effectively treat severe, pre-established heart failure in both small animal and human cell models by blocking inflammation and fibrosis (scarring of the heart tissue).

Our mouse model data are not in conflict with the epidemiological observation that a first pregnancy before age 22 greatly reduces breast cancer risk (MacMahon et al., 1970), because at this young age, the chance of having already accumulated precancerous cells is small.

The study was done using an in vitro (i.e. «in glass» or test - tube) cell culture model of the small intestinal epithelium.

As ever with electrified vehicles, there's a curious satisfaction and a fluidity to the Clarity's behaviour, and it's difficult to think of many cars that would soothe away your daily commute to quite the same extent, but Honda hasn't added to the world's (small) tally of low - emission drivers» cars with its latest fuel cell model.

The Clarity Fuel Cell model also has small EV batteries under the front seat to boost acceleration when you step on the throttle, and before the car can push enough hydrogen and air into the fuel cells stack to create electricity; think of it as fuel cell turbo Cell model also has small EV batteries under the front seat to boost acceleration when you step on the throttle, and before the car can push enough hydrogen and air into the fuel cells stack to create electricity; think of it as fuel cell turbo cell turbo lag.

While smaller and mid-sized commercial galleries struggle to find the elusive «new models» for renting and exhibiting, London's studio project spaces like ASC, Assembly Point, Cell, Cubitt and Kingsgate Workshops are taking up the slack in providing the ambitious and experimental exhibitions the city needs.

Just when you thought scientists had developed the smallest solar cells yet, they have to go and «up» the notch again with an even smaller model.

Customers make a small initial payment to have a solar PV system installed, then work under a pay - as - you - go model (like pre-paid cell phones).

Cloud droplets, for example, might be a couple hundredths of a millimeter in diameter, while the smallest grid cells that are considered in a model may be more like a couple hundred kilometers across.

Is the solution in still larger models of smaller grid cells?

Quite impressive, though I wouldn't go as far as to compare it with the few Tesla Model S fires (which I put in context here) because the situation is quite different, with only one cell getting relatively low - energy impacts over a small area compared to a whole battery pack getting a high - energy impact from a large piece of metal debris or a brick wall or whatever, and on top of that, in one of the fires the firefights drilled holes in the battery, which made things more spectacular than they otherwise would have been.

GFDL is currently working on the creation of a higher resolution coupled model with smaller grid cells.

On the other hand, climate science is in its infancy, individual models routinely fail most tests, the climate models are riddled with untested assumptions and guesses, they approximate the atmosphere with cells a hundred kilometres square and hundreds of meters high, and they do not even attempt to model individual cloud formations or any feature smaller than the cell size.