Sentences with phrase «model this disease provides»

The use of nonhuman primates to model this disease provides the most accurate representation of human Lyme disease as demonstrated in this work.

Not exact matches

«It would be interesting to model some of these diseases in mice and see if supplementing NMN provides any benefit to their behavior or memory.»

The company provides porcine models of particular diseases, models that are used to develop gene - based treatments and drugs.

As for the Lund researchers, the method provides a tool for studying how neurons cooperate inside a healthy brain and in animal models with different neurological diseases.

This is advantageous, since dogs provide new models to investigate the disease mechanisms and to plan new therapies such as gene therapy, successfully applied to blindness in dogs and human previously,» explains Lohi.

«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.

The journal provides cutting - edge research including results from animal models that are likely to apply to patients, studies in human tissue that provide new information about therapies or disease, and innovative reports of drug discovery and development.

In addition to helping understand disease by providing more powerful study models, «what this technology would allow you to do is reprogram a skin cell, for example, from a Parkinson's patient... into a pluripotent cell and then in a petri dish redirect that cell into... a neuron» to treat that patient.

It could also provide a model approach against other insect - borne diseases.

hiSCs were used to model adrenal diseases in a dish and provided a platform to test interventions for new personalised treatments.

This human - agent model of disease dynamics can then be used to provide reproducible empirical analyses, yielding greater insights into the behavioural reactions and individual responses of people threatened by outbreaks of disease.

«Cell model of the brain provides new knowledge on developmental disease.»

«Our model system provides us with fascinating insights into these mechanisms, which are also of great interest in the context of neurodegenerative diseases.»

«Traditional methods of infectious disease research using animal models have provided limited information about disease progression until the study's endpoint, when investigators could analyze tissues from those animals,» he said.

Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) provides a powerful tool for in vitro disease modeling and drug screening.

«Novel radiotracer measures olfactory neurons in animal models: Tracking deterioration in sense of smell could provide early diagnosis of neurodegenerative disease.»

Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.

Although it's still unknown exactly why DHA is able to prevent the onset of lupus, the researchers said this study provides scientists with a better model for looking at just how much DHA is needed to ward off the environmental trigger of the disease.

In mouse models of disease, Yale researchers looked at the effects of providing nutrients during infection and found opposing effects depending on whether the infections were bacterial or viral.

The disease progressed very gradually, just as it does in humans, suggesting that the hamsters could provide a useful animal model system.

This research is all aimed at tissue repair strategies, but it also may provide new in vitro models for human disease.

The researchers hope their new cell lines will be a useful resource for studying the cellular and molecular intricacies of Huntington's further, and suggest they may provide a model for examining other diseases of the brain that are specific to humans.

This work illustrates how the study of inbred canine populations can provide new insights into the genetic underpinnings of complex disease, bridging the gap between small rodent models and humans.

They also provide new information to determine when the mouse is an appropriate model to study human biology and disease, and may help to explain some of its limitations.

The team found that in large animal models, the capsule safely stayed in the stomach, slowly releasing the drug for up to 14 days, and potentially providing a new way to combat malaria and other infectious diseases.

This discovery provides a significant opportunity not only to enhance our understanding of how miRNAs regulate a variety of biological processes in an important model species for studying human diseases, but can lead to further, similar research into the role that miRNAs play in animal domestication.

These findings are promising for developing a preclinical, large animal model of Huntington's disease for assessing new therapeutics, which could ultimately provide better treatment options, including altering the course of the disease.

Roughly 75 % of disease - causing genes in humans are also found in the fruit fly, and most of the components found in human heart cells are also found in the fly heart, thus providing a model for studying cardiovascular changes.

Mizoribine provides effective treatment of sequential histological change of arteritis and reduction of inflammatory cytokines and chemokines in an animal model of Kawasaki disease

This method and such piPS cells provide safer cells for personalized regenerative medicine and more effective platform for human disease modeling.

The differentiation of patient - specific induced pluripotent stem cells (iPSCs) into has the potential to provide differentiated cells to test drugs, model diseases, and, most importantly, to replace lost or damaged tissues.

the generation of novel mouse models of Cystic Fibrosis by exploring genetically - diverse murine populations that will provide unique tools for disease modeling and pre-clinical studies.

Conversely, fundamental research using mouse models can identify genes associated with disease and provide insights into pathogenic mechanisms underlying environment - driven diseases, including infectious diseases and cancer.

The cells generated in the Zeng lab may not only provide a potential unlimited source for cell replacement therapy for Parkinson's disease, but also offer an unprecedented opportunity to develop screening models for assessing small molecule drugs and to clarify the mechanisms of disease.

BETHESDA, Md., Wed., Oct. 5, 2005 - The National Institutes of Health (NIH) today announced contracts that will give researchers unprecedented access to two private collections of knockout mice, providing valuable models for the study of human disease and laying the groundwork for a public, genome - wide library of knockout mice.

The findings mapping the structural landmarks or epitopes recognized by CD8 + cells appear in the January 12, 2017, issue of Cell Host & Microbe and provide an important tool to track Zika - specific T cells in the context of different disease models.

Non-mammalian animals like zebrafish, fruit flies, nematode worms and even seemingly more exotic creatures like salamanders and Mexican blind cavefish provide powerful experimental models for understanding fundamental biology and disease mechanisms.

Researchers from the group of Gary L. Dunbar at Central Michigan University, Michigan, USA have recently shown the ability of adenovirally generated rat iPSCs to survive and differentiate in the striatum of rats [6], and now in a study in Stem Cells Translational Medicine, they focus on the efficacy of transplantation of these cells into the 3 - nitropropionic acid (3 - NP) rat model of HD [7], which induces cell death by energy - depleting mechanisms providing an accurate model of cell loss and replicates many features of the disease [8].

These studies allow the construction of robust in vitro human disease models, and also provide a path towards precision medicine and therapeutic genome editing.

This work provided greater mechanistic understanding of airway remodeling that occurs as a result of viral exacerbation in respiratory diseases and an improved model for predicting the response to therapeutic candidates.

This paper provides direct evidence for the role of TNF in chronic intestinal inflammation using TNBS colitis in Tg197 mice as a model and encourages further clinical trials with anti-TNF therapeutics for the treatment of Crohn's disease.

Objective: To provide data - driven and computational infrastructures and data - sharing platforms to support large - scale, system - level data integration and modeling, and enable predictive biology for pathogens and host - pathogen interactions for discovery research, clinical investigation, and therapeutic development for infectious diseases.

PHENOMIN - ICS offers to generate genetically modified mouse models on a high - throughput and large scale basis, and then to provide a first phenotyping characterisation, either standardised or more specific, for a better understanding of disease mechanisms and for the development of new therapeutic treatments.

Animals provide a useful model for diseases found in both humans and other animals.

INFRAFRONTIER will provide open access to all newly developed disease models and phenotyping data.

The new model should help scientists better understand the development of Huntington's — and provide better ways to identify and screen potential therapeutics for this devastating disease.

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

These data are comparable to results obtained with more traditional individual tests of each of the relevant behaviors, suggesting that this system might provide a high - throughput means to quickly screen and characterize different rodent disease models.

«We wanted to provide a forum for researchers to trade notes on best practices when assessing behaviors in healthy and diseased animal models,» explained Gill, who organized the event.

Our in vitro study provides a baseline for defining healthy and disease - like states and highlights the power of moving beyond single and dual species applications to capture key players and their orchestrated metabolic activities within a complex human oral microbiome model.