Kontoyiannis D., Boulougouris G., Manoloukos M., Armaka M., Apostolaki M., Pizarro T., Kotlyarov A., Forster I., Flavell R., Gaestel M., Tsichlis P., Cominelli F., Kollias G., 2002, «Genetic dissection of the cellular pathways and signaling mechanisms in
modeled tumor necrosis factor - induced Crohn's - like inflammatory bowel disease», JEM, 196, 1563 - 74.
Researchers from Massachusetts Eye and Ear / Harvard Medical School have identified inflammatory factors that cause optic neuropathy in the back of the eye following implantation of a keratoprosthesis (KPro)-- similar to what glaucoma patients experience, without the rise of pressure in the eye — and have shown that blocking one of those factors,
tumor necrosis factor alpha (TNFa), successfully halts the development of optic nerve damage in a mouse
model.
I am currently working with Zika virus and how it affects the T cell response and T cell signaling through
tumor necrosis receptor (TNFR) signaling components OX40, 4 - 1BB, and CD27 in specific mouse
model systems.