Not exact matches
In order to test their hypothesis in a
model that more closely mimicked human disease, the researchers also tested the two
drugs side - by -
side on slices of tumors removed from patients during radical prostatectomy.
Researchers then used these predictive
models to understand — at the metabolic level — why some individuals experienced
side effects to ribavirin, a
drug used to treat hepatitis C, while other individuals did not.
The ultimate goal is a liver cell
model, researchers said, because the liver is where the majority of
drugs are metabolized and where many
drug side effects are manifested.
A: The traditional
model is about looking at the benefits and risks of the
drug as it relates to the person who is taking it, and weighing the outcomes versus the
side effects.
«If scientists want to test
drugs for dementia, Alzheimer's or autism, ideal
models would react similarly to humans in regards to the reduction of symptoms, outbreak of
side effects, such as enduring the same lesions as humans do, or exhibiting similar behavioral characteristics,» said Latham, who's with the College of Agriculture and Natural Resources and an MSU AgBioResearch scientist.
Researchers developed a computer
model of a human heart to study whether certain
drugs will help treat an abnormal heartbeat, or cause serious
side effects
Without a
model, the ability to evaluate potential novel therapeutics as well as possible
side effects of new
drugs has been limited.
Principal Investigator Riccardo Barrile will speak about using Organ - Chips to
model thrombosis, or the clotting of blood, which can be a
side effect of some
drugs.
The Client Information Sheet,
modeled after similar
drug information sheets included with many human
drugs, was to provide pet owners with easily understandable information about the potential
side - effects and what to do if
side - effects occur.