Sentences with phrase «models for studying disease»

Reductions in biodiversity from illegal wildlife trade can have other substantial negative human health impacts, including the loss of potential sources of pharmaceuticals, experimental models for studying disease, crop pollination and micronutrients for humans lacking alternative sources of protein.

«Investigators create complex kidney structures from human stem cells derived from adults: New technique offers model for studying disease, progress toward cell therapy.»

As a result, they contain a complete set of the genes that resulted in that disease — representing the potential of an almost perfect disease model for studying disease development, new drugs and treatments.

Not exact matches

Although the observational studies that underlie our models all adjusted for multiple confounders, including known risk factors for the disease outcomes of interest, risk factors for early breastfeeding cessation such as preterm birth, preeclampsia, and obesity are also risk factors for metabolic disease in later life.

When logistic models were stratified by the presence or absence of hypertensive disease, only maternal age older than 34 years (odds ratio [OR], 1.4; 95 % confidence interval [CI], 1.0 - 2.0), pregnancy - associated plasma protein - A of the 95th percentile or less (OR, 1.9; 95 % CI, 1.2 - 3.1), and alpha fetoprotein of the 95th percentile or greater (OR, 2.3; 95 % CI, 1.4 - 3.8) remained statistically significantly associated for abruption.In this large, population - based cohort study, abnormal maternal aneuploidy serum analyte levels were associated with placental abruption, regardless of the presence of hypertensive disease.

«I'm interested in bridging gaps between traditional epidemiology and mathematical modeling, hopefully developing improved methods for studying infectious diseases,» she says.

For researchers using mouse models to study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with disease progression.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in general.

Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

«I had been thinking about model organisms for a very long time in academia, and when I started to realize that there were all these people clamoring for their rare diseases I thought, «Why aren't people using model organisms to study them?

«This study is important, in part because we now have a new xenograft model that will for the first time allow us to apply new biomarkers to better predict disease progression and test new therapeutics.»

As for the Lund researchers, the method provides a tool for studying how neurons cooperate inside a healthy brain and in animal models with different neurological diseases.

Scientists study VSV, which causes acute disease in livestock but typically does not lead to illness in people, as a model for viruses that are harmful to humans.

«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.

This proof - of - principle study shows «for the first time... that human iPS cells can be used to model a diverse range of inherited diseases in adult cells,» the authors wrote in their paper, published online in The Journal of Clinical Investigation August 25.

Satellite imagery is used for all sorts of climate study, from identifying conditions that allow infectious diseases like West Nile virus and cholera to emerge, to creating models for predicting hurricanes, to distinguishing natural resources such as wind, water and sunlight.

In addition to helping understand disease by providing more powerful study models, «what this technology would allow you to do is reprogram a skin cell, for example, from a Parkinson's patient... into a pluripotent cell and then in a petri dish redirect that cell into... a neuron» to treat that patient.

«This is the first time a compound targeting Gaucher disease has been tested in a mouse model of Parkinson's disease and was shown to be effective,» said the study's senior author, Marie - Francoise Chesselet, the Charles H. Markham Professor of Neurology at UCLA and director of the UCLA Center for the Study of Parkinson's Ddisease has been tested in a mouse model of Parkinson's disease and was shown to be effective,» said the study's senior author, Marie - Francoise Chesselet, the Charles H. Markham Professor of Neurology at UCLA and director of the UCLA Center for the Study of Parkinson's Ddisease and was shown to be effective,» said the study's senior author, Marie - Francoise Chesselet, the Charles H. Markham Professor of Neurology at UCLA and director of the UCLA Center for the Study of Parkinson's Disstudy's senior author, Marie - Francoise Chesselet, the Charles H. Markham Professor of Neurology at UCLA and director of the UCLA Center for the Study of Parkinson's DisStudy of Parkinson's DiseaseDisease.

Both of the advantages point toward a possibility of using this new method for regenerative therapies and for creating models of rare diseases for future studies and individualized health care.

Dr Leonardo Guasti added: «It represents an entirely new concept for the study of the adrenal gland as the ability to generate donor - specific and functional adrenal - like cells will facilitate the next generation of cell - based treatments for adrenal insufficiency, the modelling of adrenal specific diseases, and the testing of personalised interventions on cells derived from patients.»

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

«This study, carried out using laboratory rats modeling stroke, demonstrated that ischemic stroke — in both its subacute and chronic stages — damages the BSCB in a variety of ways, creating a toxic environment in the spinal cord that can lead to further disability and exacerbate disease pathology,» said study lead author Dr. Svitlana Garbuzova - Davis, associate professor in USF's Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair.

In recent years, songbirds» similarities to human vocal learning have piqued researchers» interests in using them as a functional animal model to study the neurological basis for Huntington's disease.

«Finches offer researchers a new tool with which to study Huntington's disease: Like humans, songbirds learn their vocalizations, suggesting they could be useful as models for certain disorders.»

While the mouse study does not prove a direct connection between Zika infection and microcephaly, Rossi said, it does underscore the urgent need for effective animal models to further study the course of disease and its transmission.

«The next stage would be to repeat the study in primates, a more suitable animal model where HIV infection induces disease, in order to further demonstrate elimination of HIV - 1 DNA in latently infected T cells and other sanctuary sites for HIV - 1, including brain cells,» Dr. Khalili said.

«Our work and that of our colleagues on stress and CRF have been mechanistically implicated in Alzheimer's disease, but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long - term safety in animal models,» said the study's principal investigator and corresponding author Robert Rissman, PhD, assistant professor in the Department of Neurosciences and Biomarker Core Director for the Alzheimer's Disease Cooperative Study disease, but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long - term safety in animal models,» said the study's principal investigator and corresponding author Robert Rissman, PhD, assistant professor in the Department of Neurosciences and Biomarker Core Director for the Alzheimer's Disease Cooperative Study (Astudy's principal investigator and corresponding author Robert Rissman, PhD, assistant professor in the Department of Neurosciences and Biomarker Core Director for the Alzheimer's Disease Cooperative Study Disease Cooperative Study (AStudy (ADCS).

Although it's still unknown exactly why DHA is able to prevent the onset of lupus, the researchers said this study provides scientists with a better model for looking at just how much DHA is needed to ward off the environmental trigger of the disease.

«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.

«I'm hopeful the techniques successfully used in this study can be applied to make animal models for other neurodegenerative diseases,» he says.

The researchers hope their new cell lines will be a useful resource for studying the cellular and molecular intricacies of Huntington's further, and suggest they may provide a model for examining other diseases of the brain that are specific to humans.

In the new study, Lee's team tested this idea in a mouse model of Alzheimer's disease by raising the levels of one of two forms of neuregulin - 1 in the hippocampus, an area of the brain responsible for learning and memory.

«We think that for the first time, we have a mouse model of anorexia that closely resembles the conditions leading up to the disease in humans,» said study leader Lori Zeltser, PhD, associate professor of pathology & cell biology and a researcher in the Naomi Berrie Diabetes Center.

For example, the investigators teamed with Fabio Cominelli, MD, PhD, a Case Western Reserve Professor and Chief of the Division of Gastroenterology and Liver Disease, to study a mouse model of ulcerative colitis.

«The dog is an invaluable model for exploring hereditary copper - storage diseases, and observations made in this study will benefit both canine and human patient populations.»

«The induced pluripotent stem cells we used in this study proved to be extremely useful in disease modelling, and they could offer an excellent platform for drug discovery and testing new therapeutic targets for Alzheimer's disease in the future,» says Early Stage Researcher Minna Oksanen, the lead author of the study.

«For example, there is a huge amount of interest and excitement globally in growing cerebral organoids» — miniature brain - like organs that can be studied in laboratory experiments — «from stem cells to model human brain development and disease mechanisms.

Future work will focus on identifying cellular targets of ampulexins, and potentially generating a useful animal model for the study of Parkinson's disease treatments.

The researchers hope their study leads to better measures for modeling and predicting infectious disease transmission, but there are still open questions about the human - wildlife interface of disease.

Scientists use it as a model organism for studying cellular signals, disease, and the movement of cells in response to a chemical stimulus (chemotaxis).

Colorado State University biologists say this sporadic ebb and flow of prairie dog plague is an ideal model for the study of rare infectious zoonotic disease — disease that can jump from wildlife to humans — like MERS (Middle East Respiratory Syndrome) and Ebola.

Given the rapid succession of generations in yeast, we can use it as a model organism — and study the mechanisms of aneuploidy in much greater detail to find out whether we can derive from it new approaches for diagnosing and treating human diseases.»

Using data from the US Centers for Disease Control and Prevention (CDC) Multiple - Cause of Death Files (2006 - 2015), US Census Bureau, US Department of Agriculture Economic Research Service, Agency for Healthcare Research and Quality, and Northeast Regional Center for Rural Development, the study modeled associations between county - level drug - related mortality rates and economic, social, and healthcare environments.

«Previous studies of cardiac microtissues primarily used harvested rat cardiomyocytes, which is an imperfect model for human disease.»

The study of these new mouse models means an advance in the knowledge of disease's development mechanisms and an opportunity to implement new therapeutic strategies for patients.

It is worthwhile to give patients expensive new drugs that can cure their hepatitis C much earlier than some insurers are now willing to pay for them, according to a UC San Francisco study that models the effects of treating the disease early versus late in its development.

However, the study led by Pyle found that the current methods are inefficient; they produce immature cells that are not appropriate for modeling Duchenne in the laboratory or creating a cell replacement therapy for the disease.

Now OIST researchers in the Developmental Neurobiology Unit have exposed a similar syndrome in zebrafish, which are an excellent model for studying human diseases.

An important model in studying human disease, the non-coding RNA of the canine genome is an essential starting point for evolutionary and biomedical studies, according to a new study led by The Genome Analysis Centre (TGAC).

«The results of the study are truly promising, since we were able to show for the first time that A2A adenosine receptor antagonists actually have very positive effects in an animal model simulating hallmark characteristics and progression of the disease.