Sentences with phrase «models of ad»

It is the first time that both models were compared using proprietary, very sensitive behavioral tests that may have the capability to increase even predictive drug testing in animals models of AD.

These data suggest that amylin acts on the pathological cascade in animal models of AD, and further supports the therapeutic potential of amylin - type peptides for AD.

Additionally, in animal models of AD exercise improves performance on memory tasks and reduces AD - like pathology (Stranahan et al., 2012; Intlekofer and Cotman, 2013).

This duration of wheel running is in the range of wheel running protocols that have produced improvements in mouse models of AD (Stranahan et al., 2012; Intlekofer and Cotman, 2013).

Findings (i)- (iii) strongly resemble the changes seen after Abeta immunotherapy in mouse models of AD and suggest that the immune response generated against the peptide elicited clearance of Abeta plaques in this patient.

We developed several computational and machine learning methods to successfully identify behavioral patterns or signatures associated with different classes of reference drugs, from which to predict the class of novel compounds (Brunner et al., 2012, Alexandrov et al., 2015), and more recently developed methods to allow us to compare animal models of AD and its progression, and to identify (in silico) novel compounds from our existing database of thousands of novel and reference compounds with the potential to reverse the AD model behavioral profile.

Abstract: Background: Treatment with HMG - CoA reductase inhibitors («statins») has been variably associated with a reduced risk of Alzheimer's disease (AD) in epidemiologic studies and reduced amyloid - β (Aβ) deposition in animal models of AD.

Background: Treatment with HMG - CoA reductase inhibitors («statins») has been variably associated with a reduced risk of Alzheimer's disease (AD) in epidemiologic studies and reduced amyloid - β (Aβ) deposition in animal models of AD.

We measured Vc in axons of Schaffer collaterals in CA1 area of hippocampus in two transgenic mouse models of AD that over-express β - amyloid, line 41 (6mo) and APP / PS1 (24mo).

Her laboratory has successfully combined electrophysiological expertise with molecular and cell biology approaches to better understand complex mechanisms underlying the memory process in mouse models of AD.

Discovered that deficits in inhibitory interneurons lead to reduced gamma oscillatory activity, network hypersynchrony, and memory deficits in mouse models of AD.

We are currently profiling inhibitory interneuron cell types in mouse models of AD to identify potential molecular mechanisms of interneuron dysfunction and potential targets of intervention.

We are also dissecting the circuit and neuron alterations in behaving mouse models of AD using single - unit recordings and optogenetic approaches.

We established formal partnerships with major pharmaceutical and biotechnology companies to develop compounds or identify targets that enhance interneuron function or restore brain rhythms in models of AD and epilepsy.

We discovered that impaired inhibitory interneurons lead to altered oscillatory activity, network hypersynchrony, and cognitive deficits in mouse models of AD.

Discovered that mouse models of AD (APP mice) develop aberrant patterns of neuronal network activity, including network hypersynchrony, epileptiform activity, and seizures.

Interestingly, sleep deprivation markedly increased the buildup of Aβ in the brain of a mouse model of AD; whereas a drug that block orexin actions markedly decreased the buildup of Aβ.

These use a high - throughput screening approach combined with MALDI - IMS to assess the specificity of those drugs on a transgenic mouse model of AD.

Second, we propose to test the effect of chronic or acute treatment with ApoA - I - Milano in a transgenic mouse model of AD.

A ferrocentric model of AD described here forms the basis of a rational, easily testable experimental therapeutic approach for AD, which if successful, would be both widely applicable and inexpensive.

In a transgenic mouse model of AD, aducanumab is shown to enter the brain, bind parenchymal Aβ, and reduce soluble and insoluble Aβ in a dose - dependent manner.

Using a drug we know can target the garbage disposal system of the brain, we will test the effectiveness of this treatment in a model of AD.

The current project utilized an array of immunochemical and molecular tools to perform a characterization of retinal pathology in the early stages of disease progression using a well - validated mouse model of AD (APPSWE / PS1ΔE 9).

We present a nonpharmacological approach for removing Aβ and restoring memory function in a mouse model of AD in which Aβ is deposited in the brain.

Users would pay a monthly fee or adhere to the freemium model of ads within the texts in order to get to read; the publishers would then receive compensation for the books that were consumed during that month, either in full or in page - view portions.

Users would pay a monthly fee or adhere to the freemium model of ads within the texts in order to get to read; the publishers would then receive compensation... [Read more...]

Some have called 24Symbols the arrival of Spotify for e-books, since it embraces a freemium model of both ad - support for the casual user and subscription plans for those willing to pay for all - you - can - eat access.

Not exact matches

The creator of the most popular ad blocker removed it because he felt bad, but others say ad blocking is a rational response to a broken business model

Offering both subscription levels allows services like Hulu and CBS to monetize their content with revenue from both subscribers and advertisers — a model that has also been taken up by sites like YouTube and Vimeo, both of which still have their free, ad - supported content, but have also introduced paid subscription options.

Because of the long production cycles of the industry, it'll be about three years before the ads will show up in new models.

As the Internet History Podcast points out, the Internet's business model is built on online advertising, and banner ads were once a key part of that revenue stream.

Ad tech, with its breadth of data and ability to update in real time, offers robust attribution models.

Until the company can move away from an ad - driven business model (which accounts for 90 percent of revenue), it will continue to make people's data available to advertisers and potentially bad agents.

You'll still be able to get much of the same user data you're used to for ads - that is Facebook's core business model after all.

At 16, the lanky high school student caught the attention of a modeling agency and began turning up in ads and walking the runway at New York Fashion Week.

The company switched to a programmatic model, which, for simplicity's sake, can be thought of as automated, data - driven ad placement.

The ads that populate the web, the kind that know to show sneakers to a runner or business books to executives, provide a model of what personalization outside the confines browsers and traditional computer systems might look like, Battelle says:

Marco Arment, creator of the popular ad blocker «Peace,» recently pulled his app from the App Store because of this new business model.

After the trial: Hulu recently got rid of its free, ad - supported model, and lowered the rate of its base membership to $ 6 / month for the first year.

According to WordStream, PPC stands for pay - per - click, «a model of internet marketing in which advertisers pay a fee each time one of their ads is clicked.»

Unlike most other segments of the mHealth industry, weight - control apps tend to be marketed directly to consumers, either at very low cost, via an ad - supported model, or through partnerships with hardware product vendors.

«We don't support ads for your business model,» Facebook's support team responded, according to a screengrab of a message shared with the Canadian Press.

And unlike Periscope or Meerkat, it already has a monetization model in place: As opposed to ads, users can tip their favorite broadcasters using a digital currency — of which the company takes a 30 percent cut.

Jeff Malmad, Mindshare North America's head of mobile, sees that as a model for how emotional data will be used — to understand consumers» «moments of receptivity,» and not only targeting those moments with ads but also using them to create better products.

As a programmer, Gutstein believes Machinima can transition away from an ad network model — where ad impressions are bought and sold programmatically and where Ebitda margins are in the single digits — to more of a cable network model, where ads are bought and sold in packages and where Ebitda margins are anywhere from 30 % to 60 %.

The job ads site recently teamed up with Economic Modeling Specialists Intl. (EMSI) to comb through a trove of data and discover which jobs will be most in demand in the coming year.

Is there a way to enable the delivery of substance and expertise from authoritative sources, while stripping out the need for clickbait headlines, zingers and other shallow nonsense that seem to be required for survival in an ad - driven model?

As a business person, I see the weakness in the ad - supported media model online, and doubt there is some kind of floor under this market.

A spinoff site called ClickHole, which was launched in 2014 to make fun of digital media «clickbait,» uses more or less the exact same model as the publications it makes fun of: Online ads based on traffic and in some cases native advertising and sponsored content.

A key commonality of all of these new networks is that they do not run ads, instead relying on subscriptions or «freemium» models similar to that of LinkedIn, where users can upgrade to access certain features.